Association between atopy and recurrent vaginal candidiasis

Neves, Neuza Maria Alcântara; Carvalho, Lucas P.; Oliveira, Marcos André Matos de; Giraldo, Paulo César; Bacellar, Olı́via; Cruz, Ãlvaro A.; Em, Carvalho

doi:10.1111/j.1365-2249.2005.02891.x

Cited by 55 publications

(57 citation statements)

References 24 publications

(24 reference statements)

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“…19,20 A possible exception is in cases where the VVC or RVVC is due to an allergic response to a C. albicans component present in the Y form. 21 Similar to the evil transformation narrated in the novel Dr Jekyll and Mr Hyde, C. albicans changes its aspect and behaviour from a …”

Section: The Pathogen: Dr Yeast and Mr Hyphamentioning

confidence: 99%

Vulvovaginal Candida albicans infections: pathogenesis, immunity and vaccine prospects

Cassone

2014

BJOG

176

114

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Although a number of fungal species belonging to the genus Candida can cause acute vulvovaginal infection (VVC), Candida albicans is by far the most prevalent etiological agent, particularly for the most severe chronic condition known as recurrent vulvovaginal candidiasis (RVVC). This review focuses on recent advances in pathogenic mechanisms and host immune responses to C. albicans and on the utilisation of this information in the development of a vaccine to prevent and/or treat vaginal candidiasis. Currently, two vaccines with main or sole RVVC as clinical indication have completed a phase 1 clinical trial, and one of them has entered a phase 2 trial.

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Section: The Pathogen: Dr Yeast and Mr Hyphamentioning

confidence: 99%

Vulvovaginal Candida albicans infections: pathogenesis, immunity and vaccine prospects

Cassone

2014

BJOG

176

114

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“…A CVV é um problema significativo em algumas mulheres, e sua recorrência têm sido associada a processos alérgicos e alterações imunológicas 15,16 . Tradicionalmente, nos casos de alergias observa-se um aumento na população de eosinófilos.…”

Section: Discussionunclassified

“…Estudo recente confirma ainda um acréscimo importante na composição e variedade de fungos presentes na flora vaginal, como também um maior risco de aquisição de candidíase vaginal recorrente em mulheres chinesas que apresentavam rinite alérgica crônica 16 . Por outro lado, estudos com pacientes com candidí-ase mucocutânea observou um aumento e/ou a ativação de eosinófilos no sangue periférico e na derme 17 .…”

Section: Discussionunclassified

Eosinofilia no sangue periférico de mulheres com candidiase vaginal recorrente

Filho¹,

Gonçalves²,

Júnior³

et al. 2013

Rev. Bras. Ginecol. Obstet.

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ResumoOBJETIVO: Quantificar o número de células de defesa e os níveis de imunoglobulina E (IgE) no sangue periférico em amostra de mulheres com candidíase vaginal recorrente. MÉTODOS: Estudo de corte transversal com 60 mulheres, 40 com candidíase vulvovaginal e 20 do grupo controle (sem doença). As células de defesa foram identificadas utilizando um sistema de impedância combinada com a citometria de fluxo, os níveis de IgE total e específica foram medidos por meio de técnicas de quimiluminescência, o teste de Mann-Whitney foi utilizado para variáveis nominais e do teste de Spearman para correlações das concentrações de IgE e de eosinófilos no sangue periférico. RESULTADOS: O número de eosinófilos no sangue periférico de pacientes com candidíase vulvovaginal, 302,60 (±253,07), foi significativamente maior do que o grupo controle, 175,75 (±109,24) (p=0,037). Os níveis séricos de IgE total e específica foram semelhantes em ambos os grupos de mulheres com e sem candidíase vulvovaginal recorrente (p=0,361). Entretanto, observou-se uma correlação positiva moderada entre eosinofilia e níveis de IgE total no sangue periférico de mulheres com candidíase vaginal recorrente (r=0,25). CONCLUSÃO: Mulheres com candidíase vaginal recorrente parecem ter maior concentração de eosinófilos no sangue periférico que as assintomáticas. Abstract PURPOSE:To quantify the number of defense cells and immunoglobulin E (IgE) levels in peripheral blood sampled from women with recurrent vulvovaginal candidiasis. METHODS: A cross-sectional study was conducted on 60 women, 40 with vulvovaginal candidiasis and 20 controls. The defense cells were identified using an impedance system combined with flow cytometry and total and specific IgE was measured by chemiluminescence. The Mann-Whitney test was used for nominal variables and the Spearman test was used to determine the correlation of IgE concentration and eosinophils in peripheral blood. RESULTS: The number of eosinophils in peripheral blood from patients with recurrent vulvovaginal candidiasis, 302.60 (±253.07), was significantly higher compared to control, 175.75 (±109.24) (p=0.037). Serum levels of total and specific IgE were similar in the groups of women with and without recurrent vulvovaginal candidiasis (p=0.361). However, there was a moderate positive correlation between eosinophils and total serum IgE in the candidiasis group (r=0.25). CONCLUSION: Women with recurrent vulvovaginal candidiasis are more likely to have eosinophils in peripheral blood.Trabalho realizado no programa de pós-graduação em Ciências da Saúde da Universidade Federal do Rio Grande do Norte -UFRN -Natal (RN), Brasil.

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“…There is a strong association between atopy and RVVC [84], and a few studies have shown an association between RVVC and allergy to C. albicans [85], allergic conditions such as rhinitis, asthma and other familial allergies [84,86,87]. Higher levels of vaginal anticandida IgA and IgG have been reported in women with RVVC than those without [86].…”

Section: Immunological Factorsmentioning

confidence: 99%

“…Higher levels of vaginal anticandida IgA and IgG have been reported in women with RVVC than those without [86]. C. albicans can act as an allergen in some cases and it's been suggested that local hypersensitivity to the yeast can contribute to a prolongation and recurrence of genital candidiasis [84]. In support thereof a few studies have shown benefits from desensitization using Candida antigens [87], and clinical response has been observed in about 30% of women with RVVC treated with leukotriene receptor antagonist Zafirlukast [88].…”

Section: Immunological Factorsmentioning

confidence: 99%

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2017

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Association between atopy and recurrent vaginal candidiasis

Cited by 55 publications

References 24 publications

Vulvovaginal Candida albicans infections: pathogenesis, immunity and vaccine prospects

Vulvovaginal Candida albicans infections: pathogenesis, immunity and vaccine prospects

Eosinofilia no sangue periférico de mulheres com candidiase vaginal recorrente

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