Association Between Atopy and Herpetic Eye Disease

Borkar, Durga S.; Gonzales, John A.; Tham, Vivien M.; Esterberg, Elizabeth; Vinoya, Aleli C.; Parker, John V.; Uchida, Aileen; Acharya, Nisha R.

doi:10.1001/jamaophthalmol.2013.6277

Cited by 37 publications

(9 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Maturation of LCs in the presence of TSLP resulted in impaired capacity to activate antigen-specific cytotoxic T cells, compared with TNFα-matured LCs. This suggests a role for TSLP in mediating the impaired CD8 T cell responses which may be of particular relevance for atopic diseases such as asthma and atopic dermatitis which are characterized by pre-disposition to viral infections 6, 82–84 . Indeed, we and others have shown that LCs are extremely potent inducers of efficient CD8 T cell activation and anti-viral immunity 2, 3, 13, 85 .…”

Section: Discussionmentioning

confidence: 99%

Petri Net computational modelling of Langerhans cell Interferon Regulatory Factor Network predicts their role in T cell activation

Polak

Ung

Masapust

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Langerhans cells (LCs) are able to orchestrate adaptive immune responses in the skin by interpreting the microenvironmental context in which they encounter foreign substances, but the regulatory basis for this has not been established. Utilising systems immunology approaches combining in silico modelling of a reconstructed gene regulatory network (GRN) with in vitro validation of the predictions, we sought to determine the mechanisms of regulation of immune responses in human primary LCs. The key role of Interferon regulatory factors (IRFs) as controllers of the human Langerhans cell response to epidermal cytokines was revealed by whole transcriptome analysis. Applying Boolean logic we assembled a Petri net-based model of the IRF-GRN which provides molecular pathway predictions for the induction of different transcriptional programmes in LCs. In silico simulations performed after model parameterisation with transcription factor expression values predicted that human LC activation of antigen-specific CD8 T cells would be differentially regulated by epidermal cytokine induction of specific IRF-controlled pathways. This was confirmed by in vitro measurement of IFN-γ production by activated T cells. As a proof of concept, this approach shows that stochastic modelling of a specific immune networks renders transcriptome data valuable for the prediction of functional outcomes of immune responses.

show abstract

Section: Discussionmentioning

confidence: 99%

Petri Net computational modelling of Langerhans cell Interferon Regulatory Factor Network predicts their role in T cell activation

Polak

Ung

Masapust

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…While, to our knowledge, the association of Netherton syndrome and HSV has not been documented previously, there is a well-established connection between atopy and ophthalmic HSV. Patients with atopy have been shown to be twice as likely to develop ophthalmic HSV as control individuals . Severe primary, recurrent, and bilateral disease are more common in patients with atopy than unaffected patients .…”

Section: Discussionmentioning

confidence: 99%

Infectious Keratitis in a 23-Year-Old Patient With Netherton Syndrome

2020

View full text Add to dashboard Cite

“…Additionally, bilateral HSV keratitis is rare and seen more in patients with atopy or immune dysfunction. 9 Therapeutic penetrating keratoplasty (choice D) is not indicated in this patient who does not have a corneal perforation. However, prompt vitamin A supplementation is needed in such cases to prevent this devastating complication.…”

Section: Jama Ophthalmology Clinical Challengementioning

confidence: 99%

A Child With Severe Autism Spectrum Disorder With Bilateral Corneal Ulcers

2022

View full text Add to dashboard Cite

A 6-year-old boy with severe autism spectrum disorder (ASD) was brought to the hospital by his mother for whitening in the right eye. The patient was nonverbal at baseline and exhibited restrictive and repetitive behaviors. His diet consisted exclusively of cookies, apples, potato chips, and Gatorade. His mother noticed him frequently rubbing his eyes for several weeks, which she initially attributed to new-onset allergies. She did not describe any reduction in visual function or ability to perform low-luminance tasks.The patient was admitted and ophthalmology was consulted. He required an examination under sedation. His visual acuity could not be determined. There was no relative afferent pupillary defect in either eye. The eyelids were mildly erythematous with bilateral eyelash hypertrichosis. The conjunctiva and cornea appeared dry and leathery bilaterally. The right cornea was diffusely hazy with a 3-mm paracentral epithelial defect with 60% stromal thinning and a 1-mm infiltrate. There was a small crescentic fibrin deposit nasally in the right anterior chamber. The left cornea was diffusely hazy with a 1-mm epithelial defect without stromal thinning (Figure). Dilated examination showed bilateral grade 3 optic nerve head edema and otherwise normal retinal findings. Fortified vancomycin eye drops, 25 mg/mL, and tobramycin eye drops, 15 mg/mL, were initiated. Results of magnetic resonance imaging of the brain were normal.

show abstract

Association Between Atopy and Herpetic Eye Disease

Cited by 37 publications

References 31 publications

Petri Net computational modelling of Langerhans cell Interferon Regulatory Factor Network predicts their role in T cell activation

Petri Net computational modelling of Langerhans cell Interferon Regulatory Factor Network predicts their role in T cell activation

Infectious Keratitis in a 23-Year-Old Patient With Netherton Syndrome

A Child With Severe Autism Spectrum Disorder With Bilateral Corneal Ulcers

Contact Info

Product

Resources

About