Association between atopic sensitization and asthma and bronchial hyperresponsiveness in Swedish adults: Pets, and not mites, are the most important allergens☆☆☆★

Plaschke, Peter; Janson, Christer; Norrman, Eva; Björnsson, E.; Ellbjär, Susanne; Järvholm, Bengt

doi:10.1016/s0091-6749(99)70114-4

Cited by 78 publications

(71 citation statements)

References 45 publications

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“…The same observations were reported in the ECRHS studies conducted at 30 sites, mostly in Europe. 5,[13][14][15][16] Many studies have also explored the utility of total serum IgE as a marker of atopy and found some level of discordance with allergen-specific tests. 3,17 In this study, 21% of patients had a positive allergen-specific test while exhibiting normal total IgE.…”

Section: Discussionmentioning

confidence: 99%

Sensitization to Common Allergens in Adults with Asthma

Allen‐Ramey¹,

Schoenwetter²,

Weiss³

et al. 2005

The Journal of the American Board of Family Medicine

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Purpose: To estimate the prevalence of atopy (ie, allergen sensitization) in a sample of adult asthma outpatients.Methods: Population consisted of a total of 218 patients, 18 to 55 years of age, who were currently receiving care for asthma; and 13 physicians, whose specialties were Family Practice, Allergy, or Pulmonology and who were providing care to at least 10 to 15 asthma patients weekly. Patients provided a blood sample for quantification of total and allergen-specific IgE. Outcomes were the proportion of patients with atopy and the proportions of patients with elevated serum IgE specific to each of 8 specific common allergens.Results: The patients' mean age was 42 years, and 74% were women; 68% of patients met the study definition of atopy. Total serum IgE > 114 kU/L was observed in 48% of patients, and 59% had elevated levels of IgE specific to one or more of 8 common allergens.Conclusions: The majority of adult asthma outpatients had evidence of atopy and most were sensitive to a specific identifiable allergen. Awareness of the high prevalence of atopy among asthma patients might improve patient management. (J Am Board Fam Pract 2005;18:434 -9.)

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Section: Discussionmentioning

confidence: 99%

Sensitization to Common Allergens in Adults with Asthma

Allen‐Ramey¹,

Schoenwetter²,

Weiss³

et al. 2005

The Journal of the American Board of Family Medicine

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“…Cat sensitization was found to be the allergen most strongly associated with asthma and BHR in Sweden and the Netherlands [50,58,60] while in India, Belgium and the UK the association with asthma or BHR was strongest for mite [28,54,59]. The attributable risk of atopic sensitization for BHR was found to be 19% in Sweden and 21% in Spain [50,63], while the attributable risk of atopy for current asthma was 26% and 42% in Sweden and Spain, respectively [50,64]. In Spain, sensitization to Alternaria, olive, timothy grass and cat were found to be independent predictors for lower FEV1 after adjusting for smoking and bronchial responsiveness [65].…”

Section: Risk Factorsmentioning

confidence: 98%

“…Females have a higher prevalence of current asthma than males in several of the local analyses [48][49][50]. SUNYER et al [39] found that females had a lower risk of asthma with onset before 15 yrs of age but a higher risk of adult onset asthma than males.…”

Section: Risk Factorsmentioning

confidence: 99%

“…Several investigations have found an association between allergic sensitization and asthma or BHR using local data sets [28,32,39,49,50,[52][53][54][59][60][61][62]. Cat sensitization was found to be the allergen most strongly associated with asthma and BHR in Sweden and the Netherlands [50,58,60] while in India, Belgium and the UK the association with asthma or BHR was strongest for mite [28,54,59].…”

Section: Risk Factorsmentioning

confidence: 99%

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The European Community Respiratory Health Survey: what are the main results so far?

et al. 2001

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The European Community Respiratory Heath Survey (ECRHS) was the first study to assess the geographical variation in asthma and allergy in adults using the same instruments and definitions. The database of the ECRHS includes information fromy140,000 individuals from 22 countries. The aim of this review is to summarize the results of the ECRHS to date.The ECRHS has shown that there are large geographical differences in the prevalence of asthma, atopy and bronchial responsiveness, with high prevalence rates in English speaking countries and low prevalence rates in the Mediterranean region and Eastern Europe. Analyses of risk factors have highlighted the importance of occupational exposure for asthma in adulthood. The association between sensitization to individual allergens and bronchial responsiveness was strongest for indoor allergens (mite and cat). Analysis of treatment practices has confirmed that the treatment of asthma varies widely between countries and that asthma is often undertreated.In conclusion, the European Community Respiratory Health Survey has shown that the prevalence of asthma varies widely. The fact that the geographical pattern is consistent with the distribution of atopy and bronchial responsiveness supports the conclusion that the geographical variations in the prevalence of asthma are true and most likely due to environmental factors. Eur Respir J 2001; 18: 598-611. During the first half of the 1990s, information on the variation in asthma prevalence, known or suspected risk factors for atopy and asthma, and information on the management of asthma in young adults was collected in the European Community Respiratory Health Survey (ECRHS).The reason for undertaking the ECRHS was a rapid increase in the prevalence of asthma that had been reported from many different countries [1][2][3][4]. This increase was over too short a time period to be explained by genetic factors and must therefore have been related to nongenetic or environmental changes. Further evidence of the importance of environmental factors in asthma was that studies comparing prevalence in urban and rural areas in developing countries had shown large differences in asthma prevalence [5][6][7]. Treatment patterns of asthma [8] and asthma mortality [9] had been found to vary considerably in Europe which raised the question of whether the variation in mortality was due to geographical differences in the prevalence of asthma or differences in asthma fatality. Research directed towards identifying the environmental factors that explain this geographical variation in asthma was required to identify potential strategies to counter the global increase in the prevalence of asthma.The information available on the variation in the prevalence of asthma and allergy at the beginning of the 1990s had been collected through several studies using different protocols. The ECRHS was, therefore, the first study that assessed the prevalence of asthma and allergic disease in a large number of countries

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“…These include parental mouth cleaning of pacifiers [4], hand washing dishes [5], using feather bedding materials [6], having a pet in the house [7], drinking unpasteurised milk [8] and regular visits to animal stables [9]. At first glance, putting an infant on an animal fur ( presumably largely sheepskins) to sleep might be expected to have similar effects to coming into close contact with farm animals.…”

mentioning

confidence: 99%

Animal fur and asthma: an indoor farmyard phenomenon?

Crane

2015

Eur Respir J

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Association between atopic sensitization and asthma and bronchial hyperresponsiveness in Swedish adults: Pets, and not mites, are the most important allergens☆☆☆★

Cited by 78 publications

References 45 publications

Sensitization to Common Allergens in Adults with Asthma

Sensitization to Common Allergens in Adults with Asthma

The European Community Respiratory Health Survey: what are the main results so far?

Animal fur and asthma: an indoor farmyard phenomenon?

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