Association between atherogenic index of plasma and prehypertension or hypertension among normoglycemia subjects in a Japan population: a cross-sectional study

Abstract

Objective The atherogenic index of plasma (AIP), consisting of triglycerides and high-density lipoprotein cholesterol, is applied to estimate the cardiovascular disease risk. The evidence regarding the association between AIP and prehypertension or hypertension remains inconclusive. This study was conducted to investigate the association of AIP and prehypertension or hypertension in normoglycemic subjects in Japan. Methods In the present cross-sectional study, 15,453 normoglycemic participants aged 18 years or older in Gifu, Japan, were evaluated. The selected participants were separated into four groups in the light of AIP quartiles, ranging from the lowest quartile (Q1) to the highest quartile (Q4). And the association between AIP and prehypertension or hypertension was explored with multivariate logistic regression by gradually adjusting model. Results Among the 15,453 participants, aged of 43.7 ± 8.9 years, and of whom 45.5% were females, the prevalence rates of prehypertension or hypertension were 27.68% (4,278) and 6.23% (962) respectively. In multivariate logistic regression analyses, participants in the highest AIP quartile had an increase risk in prehypertension and hypertension, compared with participants the lowest one, the odds ratios (OR) were 1.15 (95%CI: 1.00–1.13, P = 0.045) for prehypertension and 1.54 (95%CI:1.16–2.04, P = 0.003) for hypertension after adjusting confounders. In subgroup analyses, the high risk of hypertension was also observed for female participants in the highest AIP quartile (Q4) (OR = 2.19, 95%CI: 1.37–3.49, P = 0.001), especially between the ages of 40 and 60 years (OR = 2.20, 95%CI: 1.24–3.88, P = 0.007). Conclusions Higher AIP is significantly and positively associated with the risk of prehypertension or hypertension in normoglycemic subjects in Gifu, Japan, which was more pronounced in the female population, especially between the years of 40 and 60.

Association between atherogenic index of plasma and new-onset stroke in individuals with different glucose metabolism status: insights from CHARLS

“…Min et al have found that individuals with abnormal glucose metabolism and higher AIP levels may have a greater risk of developing cardiovascular diseases [ 25 ]. In addition, higher levels of AIP have been found to be positively correlated with the risk of hypertension and non-alcoholic fatty liver disease, which is potentially influenced by the glucose metabolic states [ 26 – 28 ]. Interestingly, a cross-sectional study has demonstrated a strong association among elevated AIP levels, an increased risk of IR, and the onset of type 2 diabetes [ 6 ].…”

Association between atherogenic index of plasma and new-onset stroke in individuals with different glucose metabolism status: insights from CHARLS

“…Min et al have found that individuals with abnormal glucose metabolism and higher AIP levels may have a greater risk of developing cardiovascular diseases (24). In addition, higher levels of AIP have been shown to be positively correlated with the risk of hypertension and non-alcoholic fatty liver disease, with this relationship potentially in uenced by the glucose metabolic states (25)(26)(27). Interestingly, a cross-sectional study has shown a strong association between elevated AIP levels and an increased risk of insulin resistance and the onset of type 2 diabetes (5).…”

Nonlinear association between atherogenic index of plasma and type 2 diabetes mellitus in overweight and obesity patients: evidence from Chinese medical examination data

“…In 2001, Dobiásová and Frohlich proposed the AIP as an improved indicator of blood lipids [ 7 ]. Due to its affordability and accessibility, the AIP has been utilized in the treatment of various conditions, including hypertension [ 8 ], obesity [ 9 ], and metabolic syndrome [ 10 ]. Studies have also discovered a strong association between AIP and T2DM [ 11 , 12 ], with higher AIP levels indicating an increased risk of developing T2DM.…”