Association between asymptomatic sexually transmitted infections and high-risk human papillomavirus in cervical lesions

Wang, Lei; Zhu, Lizhe; Li, Han; Ma, Nan; Huang, Huifang; Li, Ying; Fang, Jing

doi:10.1177/0300060519865633

Cited by 7 publications

(10 citation statements)

References 28 publications

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“…Previously published studies have in fact reported a high prevalence of the HPV 51 genotype in Italian women [15,18,19]. The high prevalence of HPV 16 is in keeping with the worldwide spread of this genotype, not only among women but also in the male population [6,9,14,20,21].…”

Section: Discussionmentioning

confidence: 77%

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Prevalence of Human Papillomavirus (HPV) and Other Sexually Transmitted Infections (STIs) among Italian Women Referred for a Colposcopy

Martinelli

Musumeci

Sechi

et al. 2019

IJERPH

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Sexually transmitted infections (STIs) represent a major cause of morbidity in women and men worldwide. Human Papillomavirus (HPV) infections are among the most prevalent STIs and persistent infections with high-risk HPV (hrHPV) genotypes can cause cervical dysplasia and invasive cervical cancer. The association of other STIs with HPV cervical infection and/or dysplasia has however not yet been fully elucidated. The aim of this study was to assess the prevalence of HPV and other STIs among women presenting with an abnormal cervical cytology. Cervical infections with 28 HPV genotypes and seven other sexually transmitted pathogens were evaluated in 177 women referred for a colposcopy after an abnormal Pap smear. Positivity for at least one hrHPV genotype was shown in 87% of women; HPV 16 was the most prevalent (25.0%), followed by HPV 31 and HPV 51. The overall positivity for other STIs was 49.2%, with Ureaplasma parvum being the most prevalent microrganism (39.0%). Co-infections between hrHPV and other STIs were demonstrated in 17.5% of women; no significant association was demonstrated between multiple infections and the colposcopy findings. This study provides new epidemiological data on the prevalence of cervical infections associated with HPV and seven other common sexually transmitted pathogens in a population of women presenting with an abnormal cervical cytology.

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Section: Discussionmentioning

confidence: 77%

“…There is growing evidence on the role of other Sexually Transmitted Infections (STIs) as co-factors for the development of cervical cancer in HPV-positive women [8,9]. Interactions between HPV and other pathogens that share similar mucosal sites could accelerate cancer progression, enhancing HPV replication and infection persistence.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Human Papillomavirus (HPV) and Other Sexually Transmitted Infections (STIs) among Italian Women Referred for a Colposcopy

Martinelli

Musumeci

Sechi

et al. 2019

IJERPH

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“…Recent studies have indicated the potential role of sexually transmitted infections (STIs) in the development of cervical cancer in HPV-positive women [ 7 ]. Interactions between high-risk HPV (hrHPV) infections and other pathogens could accelerate cancer progression, enhancing HPV replication and persistence of infection.…”

Section: Introductionmentioning

confidence: 99%

“…A high prevalence of STIs has also recently been reported in Italy in association with hrHPV and cervical dysplasia [ 8 ]. Wang and colleagues reported an association between Ureaplasma urealyticum (UU) subtypes and cervical cancer [ 7 ]; further studies reported that Chlamydia trachomatis (CT) increases the risk of cervical cancer [ 9 , 10 ]. Multiple STIs are therefore believed to represent a risk factor for cervical cancer [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Different Self-Sampling Devices for Molecular Detection of Human Papillomavirus (HPV) and Other Sexually Transmitted Infections (STIs): A Pilot Study

et al. 2022

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Background: Cervical cancer is the fourth most common cancer in women, and it is well known that high-risk human papillomavirus (hrHPV) infections are the necessary carcinogenic factors for the development of cervical tumors. Moreover, the interaction between HPV and other sexually transmitted infections (STIs) may increase the risk of cancer progression. Self-sampling has been demonstrated to represent a valid and well-accepted alternative, favoring women’s participation in screening programs. This study aimed to investigate the use of FLOQSwabs® (FS) as compared to two other vaginal self-collection devices for the detection of hrHPV and other sexually transmitted infections. Methods: Cervical and vaginal self-samples were collected, using two different combinations of vaginal self-sampling devices, from 40 women referred to colposcopy for a documented abnormal Pap smear. All samples were tested for hrHPV and seven STI pathogens using two commercial molecular assays. Results: Data on hrHPV detection from the first group of women showed an almost perfect agreement (kappa: 0.89) between cervical vs. FS vaginal self-samples, and a substantial agreement (kappa: 0.79) between cervical and HerSwab™ (HS) samples. In the second group of women, an almost perfect agreement (kappa: 0.90) was demonstrated in the detection of hrHPV between cervical samples vs. FS, and a moderate agreement (kappa: 0.60) for cervical vs. Evalyn®Brush (EB) self-collected samples. STI detections showed a very good agreement (kappa: 0.89 and kappa: 1.00) both among FS vs. HS and FS vs. EB, respectively. There was no statistically significant difference between the different devices used. The most frequently detected hrHPV genotypes in the studied population were HPV 16, 31, 35, 51, and 56; whilst the most frequently identified STI pathogens were Ureaplasma parvum and Mycoplasma hominis. Overall, investigated women did not report any discomfort in using the different vaginal self-collection devices. Conclusion: Evaluation of the three different vaginal self-collection devices confirmed their overall good acceptability by the studied population, as well as a similar agreement for hrHPV detection as compared to cervical samples. Our study indicated that the use of self-collected samples offers an alternative strategy to improve women’s participation in cervical cancer screening programs, but also underlined the importance of evaluating the concordance in hrHPV detection of collection devices in combination with the molecular hrHPV assay.

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“…Possible synergistic effects also existed between CT, Uup3, Uup6, and Mh infections and HR-HPV infection ( Table III ). CT, Uup3, Uup6, and Mh likely contribute to HPV infection ( 25 ), which was different from the species that contributed to CIN progression. Combined with the results presented in Table IV , we note that it is not the exact same species of pathogen with that in Table III , that could promote CIN progression though mostly similar.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the association between ten pathogens causing sexually transmitted diseases and high‑risk human papilloma virus infection in Shanghai

Xie

Dong

et al. 2021

Mol Clin Oncol

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Cervical cancer, one of the high-incidence female malignant tumors, has predominated in recent years. Persistent infection with high-risk human papillomavirus (HR-HPV) is the main cause of cervical cancer. Studies have shown that infection with certain sexually transmitted disease (STD) pathogens increases the risk of persistent infection with HR-HPV and is a high-risk factor for cervical cancer. In the present study, cervical specimens were collected for Thinprep cytology test detection, while DNA of cervical cells was extracted for HPV genotyping and detection of 10 STD pathogens, including Neisseria gonorrhoeae , Chlamydia trachomatis (CT), Ureaplasma urealyticum , Ureaplasma urealyticum parvum (Uup)1, Uup3, Uup6, Uup14, Mycoplasma hominis (Mh), Mycoplasma genitalium (Mg) and herpes simplex virus II. Significant differences were observed between CT, Mh and Mg infections and HR-HPV infection (P<0.05). In addition, CT, Uup3, Uup6 and Mh infections were associated with HR-HPV infection (odds ratio >1; P<0.05). In the comparison of Uup3, Uup6 and Mg infections between the cervical intraepithelial neoplasia (CIN) group and the control group, statistically significant differences were observed (P<0.05). In conclusion, the incidences of CT, Mh and Mg infections were similar with HR-HPV infection. CT, Uup6, Mh and Mg infections were risk factors for HR-HPV infection. Finally, Uup3, Uup6 and Mg were risk factors of CIN.

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Association between asymptomatic sexually transmitted infections and high-risk human papillomavirus in cervical lesions

Cited by 7 publications

References 28 publications

Prevalence of Human Papillomavirus (HPV) and Other Sexually Transmitted Infections (STIs) among Italian Women Referred for a Colposcopy

Prevalence of Human Papillomavirus (HPV) and Other Sexually Transmitted Infections (STIs) among Italian Women Referred for a Colposcopy

Comparison of Different Self-Sampling Devices for Molecular Detection of Human Papillomavirus (HPV) and Other Sexually Transmitted Infections (STIs): A Pilot Study

Investigation of the association between ten pathogens causing sexually transmitted diseases and high‑risk human papilloma virus infection in Shanghai

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