Association between asymptomatic median mononeuropathy and diabetic polyneuropathy severity in patients with diabetes mellitus

Stamboulis, Eleftherios; Voumvourakis, Konstantinos; Andrikopoulou, Athina; Tentolouris, Nicholas; Kodounis, Adonis; Tsivgoulis, Georgios

doi:10.1016/j.jns.2008.11.006

Cited by 18 publications

(12 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This and our extensive sampling enabled us to identify the characteristic pathology of DPN, including axonal loss and segmental demyelination. The similar correlations we found between IME density and motor amplitudes of both the median and ulnar nerves suggest our findings are due to diabetic polyneuropathy rather than an isolated compressive median mononeuropathy (Stamboulis et al ., ) .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of dermal myelinated nerve fibers in diabetes mellitus

Peltier¹,

Myers²,

Artibee³

et al. 2013

J Peripheral Nervous Sys

View full text Add to dashboard Cite

Skin biopsies have primarily been used to study the non-myelinated nerve fibers of the epidermis in a variety of neuropathies. In the present study, we have expanded the skin biopsy technique to glabrous, non-hairy skin to evaluate myelinated nerve fibers in the most highly prevalent peripheral nerve disease, diabetic polyneuropathy (DPN). Twenty patients with DPN (Type I, n=9; Type II, n=11) and sixteen age-matched healthy controls (ages 29–73) underwent skin biopsy of the index finger, nerve conduction studies, and composite neuropathy scoring. In patients with DPN, we found a statistically significant reduction of both mechanoreceptive Meissner corpuscles (MC) and their afferent myelinated nerve fibers (p=0.01). This myelinated nerve fiber loss was correlated with the decreased amplitudes of sensory/motor responses in nerve conduction studies. This study supports the utilization of skin biopsy to quantitatively evaluate axonal loss of myelinated nerve fibers in patients with DPN.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of dermal myelinated nerve fibers in diabetes mellitus

Peltier¹,

Myers²,

Artibee³

et al. 2013

J Peripheral Nervous Sys

View full text Add to dashboard Cite

show abstract

“…Carpal tunnel syndrome (CTS), which results in compression of the median nerve by the transverse carpal ligament, is often included in discussions of the diabetic hand, even though it is considered a compression neuropathy. Nonetheless, it is one of the most prevalent pathological changes in the diabetic hand, with CTS observed in 14–60% of diabetic patients . Cumulatively, these pathologic changes impact hand function resulting in weakened grip, lower dexterity and decreased ability to perform fine finger motions …”

Section: Clinical Burdens Manifestations and Complications Of T2dm Omentioning

confidence: 99%

Effects of Type II Diabetes Mellitus on Tendon Homeostasis and Healing

Nichols

Loiselle

2019

Journal Orthopaedic Research

View full text Add to dashboard Cite

Over 300,000 tendon repairs are performed annually in the United States to repair damage to tendons as a result of either acute trauma or chronic tendinopathy. Individuals with type II diabetes mellitus (T2DM) are four times more likely to experience tendinopathy, and up to five times more likely to experience a tendon tear or rupture than non‐diabetics. As nearly 10% of the US population is diabetic, with an additional 33% pre‐diabetic, this is a particularly problematic health care challenge. Tendon healing in general is challenging and often unsatisfactory due to the formation of mechanically inferior scar‐tissue rather than regeneration of native tendon structure. In T2DM tendons, there is evidence of an amplified scar tissue response, which may be associated with the increased the risk of rupture or impaired restoration of range of motion. Despite the dramatic effect of T2DM on tendon function and outcomes following injury, there are few therapies available to promote improved healing in these patients. Several recent studies have enhanced our understanding of the pro‐inflammatory environment of T2DM healing and have assessed potential treatment approaches to mitigate pathological progression in pre‐clinical models of diabetic tendinopathy. This review discusses the current state of knowledge of diabetic tendon healing from molecular to mechanical disruptions and identifies promising approaches and critical knowledge gaps as the field moves toward identification of novel therapeutic strategies to maintain or restore tendon function in diabetic patients. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:13–22, 2020

show abstract

“…The same investigator performed the electrophysiological studies in all patients, and standard procedures were used as described previously 22,23. Motor nerve conduction studies (NCSs) of the right ulnar and peroneal nerves were performed.…”

Section: Methodsmentioning

confidence: 99%

There is No Association between Cardiovascular Autonomic Dysfunction and Peripheral Neuropathy in Chronic Hemodialysis Patients

et al. 2010

Self Cite

View full text Add to dashboard Cite

Background and PurposeThe potential association between the severity of autonomic dysfunction and peripheral neuropathy has not been extensively investigated, with the few studies yielding inconsistent results. We evaluated the relationship between autonomic dysfunction and peripheral neuropathy in chronic hemodialysis patients in a cross-sectional study.MethodsCardiovascular autonomic function was assessed in 42 consecutive patients with chronic renal failure treated by hemodialysis, using a standardized battery of 5 cardiovascular reflex tests. Symptoms of autonomic dysfunction and of peripheral neuropathy were evaluated using the Autonomic Neuropathy Symptom Score (ANSS) and the Neuropathy Symptoms Score. Neurological deficits were assessed using the Neuropathy Disability Score. Conduction velocities along the sensory and motor fibers of the sural and peroneal nerves were measured. Thermal thresholds were documented using a standardized psychophysical technique.ResultsParasympathetic and sympathetic dysfunction was prevalent in 50% and 28% of cases, respectively. Peripheral neuropathy was identified in 25 cases (60%). The prevalence of peripheral neuropathy did not differ between patients with impaired (55%) and normal (75%) autonomic function (p=0.297; Fisher's exact test). The electrophysiological parameters for peripheral nerve function, neuropathic symptoms, abnormal thermal thresholds, age, gender, and duration of dialysis did not differ significantly between patients with and without autonomic dysfunction. Patients with autonomic dysfunction were more likely to have an abnormal ANSS (p=0.048). The severity of autonomic dysfunction on electrophysiological testing was positively correlated with ANSS (r=0.213, p=0.036).ConclusionsThe present data indicate that although cardiovascular autonomic dysfunction is prevalent among patients with chronic renal failure, it is not associated with the incidence of peripheral neuropathy.

show abstract

Association between asymptomatic median mononeuropathy and diabetic polyneuropathy severity in patients with diabetes mellitus

Cited by 18 publications

References 19 publications

Evaluation of dermal myelinated nerve fibers in diabetes mellitus

Evaluation of dermal myelinated nerve fibers in diabetes mellitus

Effects of Type II Diabetes Mellitus on Tendon Homeostasis and Healing

There is No Association between Cardiovascular Autonomic Dysfunction and Peripheral Neuropathy in Chronic Hemodialysis Patients

Contact Info

Product

Resources

About