Association between asymptomatic carotid stenosis and cognitive function: A systematic review

Chang, Xueli; Zhou, Huijie; Lei, Chunyan; Wu, Bo; Chen, Yan-Chao; Zeng, Hao; Dong, Wei; Liu, Ming

doi:10.1016/j.neubiorev.2013.05.011

Cited by 46 publications

(25 citation statements)

References 43 publications

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“…Symptomatic and asymptomatic carotid stenosis may be associated with existing cognitive impairments (Chang et al, 2013;Mathiesen et al, 2004). Our results show that not only patients with significant carotid artery stenosis, but also patients with PAD appear to have cognitive deficits at baseline.…”

Section: Preoperative Cognitionmentioning

confidence: 58%

“…This may reflect that patients with similar risk factors such as diabetes, hypertension, hypercholesterolemia, current smoking, and so on, and proven PAD but without carotid artery disease may suffer from similar cognitive deficits (Chang et al, 2013).…”

Section: Preoperative Cognitionmentioning

confidence: 99%

“…Furthermore we used a comprehensive neuropsychological test battery. The study did not rely on short-screenings instruments such as the MMSE, which are considered insufficient (Chang et al, 2013;Plessers et al, 2014). Finally, we had a very low dropout at 1 and 6 months, preventing possible subgroup confounders.…”

Section: Outcome After Carotid Revascularizationmentioning

confidence: 99%

“…Furthermore, symptomatic as well as asymptomatic carotid stenoses have been described to be associated with cognitive disturbances (Chang et al, 2013;Mathiesen et al, 2004). Silvestrini et al (2009) demonstrated that unilateral left-and right-sided asymptomatic carotid stenosis affects cognitive abilities specific to the ipsilateral hemisphere.…”

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confidence: 99%

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Prospective comparison of cognitive effects of carotid endarterectomy versus carotid stenting with flow reversal or distal filters

Plessers

Herzeele

Hemelsoet

et al. 2015

Journal of Clinical and Experimental Neuropsychology

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Section: Preoperative Cognitionmentioning

confidence: 58%

Section: Preoperative Cognitionmentioning

confidence: 99%

Section: Outcome After Carotid Revascularizationmentioning

confidence: 99%

mentioning

confidence: 99%

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Prospective comparison of cognitive effects of carotid endarterectomy versus carotid stenting with flow reversal or distal filters

Plessers

Herzeele

Hemelsoet

et al. 2015

Journal of Clinical and Experimental Neuropsychology

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show abstract

“…A recent systematic review reported that 9/10 studies involving 763 patients with a >50% asymptomatic carotid stenosis and 6308 non-carotid stenosis controls, reported an association between an asymptomatic carotid stenosis and cognitive impairment. 56 More recently, an Italian study has reported that patients with severe bilateral (asymptomatic) carotid stenoses may be at risk of developing cognitive impairment. 57 In both the systematic review 56 and Buratti's paper, 57 it was very unclear whether this was a causal association (ie secondary to silent embolisation or hypoperfusion) or (more likely) to the fact that most of the risk Table 3 e Temporal changes in the 5 year risk of 'any' and 'ipsilateral' stroke in medically treated patients randomised within ACAS and ACST.…”

Section: In Conclusionmentioning

confidence: 99%

Why is the management of asymptomatic carotid disease so controversial?

Naylor

2015

The Surgeon

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The inescapable conclusion is that only a relatively small proportion of asymptomatic patients benefit from prophylactic CEA/CAS. The key question, therefore, remains; is society prepared to invest sufficient resources in identifying these 'high risk for stroke' patients so that they can benefit from aggressive BMT and CEA or CAS, leaving the majority of lower risk patients to be treated medically?

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The mid-term effects of carotid endarterectomy on cognition and regional neural activity analyzed with the amplitude of low frequency fluctuations technique

et al. 2021

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Purpose The study aims to evaluate the mid-term effects of carotid endarterectomy (CEA) on cognition and resting-state functional magnetic resonance imaging (rs-fMRI) using the Amplitude of Low Frequency Fluctuations (ALFF) technique. Methods In this observational study, patients eligible for CEA were prospectively included. On the same day, within 1 week of the CEA procedure performed and 12 months after the CEA procedure, all patients underwent (i) an MRI examination for rs-fMRI analysis and (ii) a cognitive evaluation using the Italian version of the Mini-Mental State Examination (MMSE) corrected for age and schooling. Pre-CEA and post-CEA MMSE scores were evaluated using paired sample t-tests, adopting a p-value < 0.05 as statistical threshold. The ALFF technique was used for analyzing the differences between pre-CEA and post-CEA rs-fMRI scans in terms of regional neural activation. This was accomplished by applying non-parametric statistics based on randomization/permutation for cluster-level inferences, adopting a cluster-mass p-value corrected for false discovery < 0.05 for cluster threshold, and a p-uncorrected < 0.01 for the voxel threshold. Results Twenty asymptomatic patients were enrolled. The mean MMSE score resulted improved following CEA procedure (p-value = 0.001). The ALFF analysis identified a single cluster of 6260 voxels of increased regional neural activity following CEA, and no cluster of reduced activity. The majority of voxels covered the right precentral gyrus, the right middle frontal gyrus, and the anterior division of the cingulate gyrus. Conclusion Mid-term cognitive improvements observed after CEA are associated to increased regional neural activity of several cerebral regions.

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Association between asymptomatic carotid stenosis and cognitive function: A systematic review

Cited by 46 publications

References 43 publications

Prospective comparison of cognitive effects of carotid endarterectomy versus carotid stenting with flow reversal or distal filters

Prospective comparison of cognitive effects of carotid endarterectomy versus carotid stenting with flow reversal or distal filters

Why is the management of asymptomatic carotid disease so controversial?

The mid-term effects of carotid endarterectomy on cognition and regional neural activity analyzed with the amplitude of low frequency fluctuations technique

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