Association between asthma status and prenatal antibiotic prescription fills among women in a Medicaid population

Snyder, Brittney M.; Patterson, Megan F.; Gebretsadik, Tebeb; Cacho, Ferdinand; D, Tan; Turi, Kedir N.; Abreo, Andrew; Wu, Pingsheng; Hartert, Tina V.

doi:10.1080/02770903.2021.1993247

Cited by 4 publications

(1 citation statement)

References 32 publications

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“…Since people with asthma tend to be prescribed antibiotics frequently (33) and oral antibiotic exposure is a risk factor for the acquisition of ARGs in the gut (11), we wanted to determine if the members of our asthma cohort were more likely to have received antibiotics. To test this, we counted how many subjects had taken a course of antibiotics within one year of their participation in the study.…”

Section: Richness Of Antibiotic Resistance Genes Is Increased In the ...mentioning

confidence: 99%

The gut metagenome harbors metabolic and antibiotic resistance signatures of moderate-to-severe asthma

Wilson

Hernandez-Leyva

Schwartz

et al. 2023

Preprint

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Asthma is a common allergic airway disease that develops in association with the human microbiome early in life. Both the composition and function of the infant gut microbiota have been linked to asthma risk, but functional alterations in the gut microbiota of older patients with established asthma remain an important knowledge gap. Here, we performed whole metagenomic shotgun sequencing of 95 stool samples from 59 healthy and 36 subjects with moderate-to-severe asthma to characterize the metagenomes of gut microbiota in children and adults 6 years and older. Mapping of functional orthologs revealed that asthma contributes to 2.9% of the variation in metagenomic content even when accounting for other important clinical demographics. Differential abundance analysis showed an enrichment of long-chain fatty acid (LCFA) metabolism pathways which have been previously implicated in airway smooth muscle and immune responses in asthma. We also observed increased richness of antibiotic resistance genes (ARGs) in people with asthma. One differentially abundant ARG was a macrolide resistance marker, ermF, which significantly co-occurred with the Bacteroides fragilis toxin, suggesting a possible relationship between enterotoxigenic B. fragilis, antibiotic resistance, and asthma. Lastly, we found multiple virulence factor (VF) and ARG pairs that co-occurred in both cohorts suggesting that virulence and antibiotic resistance traits are co-selected and maintained in the fecal microbiota of people with asthma. Overall, our results show functional alterations via LCFA biosynthetic genes and increases in antibiotic resistance genes in the gut microbiota of subjects with moderate-to-severe asthma and could have implications for asthma management and treatment.

show abstract

Section: Richness Of Antibiotic Resistance Genes Is Increased In the ...mentioning

confidence: 99%

The gut metagenome harbors metabolic and antibiotic resistance signatures of moderate-to-severe asthma

Wilson

Hernandez-Leyva

Schwartz

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Global prevalence of antibiotic consumption during pregnancy: A systematic review and meta-analysis

Orwa,

Gudnadottir,

Boven

et al. 2024

Journal of Infection

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The gut metagenome harbors metabolic and antibiotic resistance signatures of moderate-to-severe asthma

Wilson,

Hernandez-Leyva,

Schwartz

et al. 2024

FEMS Microbes

View full text Add to dashboard Cite

Asthma is a common allergic airway disease that has been associated with the development of the human microbiome early in life. Both the composition and function of the infant gut microbiota have been linked to asthma risk, but functional alterations in the gut microbiota of older patients with established asthma remain an important knowledge gap. Here, we performed whole metagenomic shotgun sequencing of 95 stool samples from a cross-sectional cohort of 59 healthy and 36 subjects with moderate-to-severe asthma to characterize the metagenomes of gut microbiota in adults and children 6 years and older. Mapping of functional orthologs revealed that asthma contributes to 2.9% of the variation in metagenomic content even when accounting for other important clinical demographics. Differential abundance analysis showed an enrichment of long-chain fatty acid (LCFA) metabolism pathways which have been previously implicated in airway smooth muscle and immune responses in asthma. We also observed increased richness of antibiotic resistance genes (ARGs) in people with asthma. Several differentially abundant ARGs in the asthma cohort encode resistance to macrolide antibiotics, which are often prescribed to patients with asthma. Lastly, we found that ARG and virulence factor (VF) richness in the microbiome were correlated in both cohorts. ARG and VF pairs co-occurred in both cohorts suggesting that virulence and antibiotic resistance traits are co-selected and maintained in the fecal microbiota of people with asthma. Overall, our results show functional alterations via LCFA biosynthetic genes and increases in antibiotic resistance genes in the gut microbiota of subjects with moderate-to-severe asthma and could have implications for asthma management and treatment.

show abstract

Association between asthma status and prenatal antibiotic prescription fills among women in a Medicaid population

Cited by 4 publications

References 32 publications

The gut metagenome harbors metabolic and antibiotic resistance signatures of moderate-to-severe asthma

The gut metagenome harbors metabolic and antibiotic resistance signatures of moderate-to-severe asthma

Global prevalence of antibiotic consumption during pregnancy: A systematic review and meta-analysis

The gut metagenome harbors metabolic and antibiotic resistance signatures of moderate-to-severe asthma

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