Association between asthma and serum adiponectin concentration in women

Sood, Akshay; Cui, Xichun; Qualls, Clifford; Beckett, William S.; Gross, Myron D.; Steffes, Michael W.; Smith, Lewis J.; Jacobs, David R.

doi:10.1136/thx.2007.090803

Cited by 134 publications

(129 citation statements)

References 32 publications

(34 reference statements)

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“…findings of our longitudinal study suggest a clear direction to our previously described cross-sectional association between serum adiponectin and asthma among women (6). Although serum adiponectin concentrations and BMI are inversely correlated with each other (r of 20.33; P , 0.001), we found that low values of the former may be more important than high values of the latter in predicting the risk for incident asthma among female current smokers.…”

Section: Discussionsupporting

confidence: 69%

“…The strengths of our study include its focus on women, welldefined study population set within a cohort structure, and its clinical translational character, based on the recently published data on the role of systemic adiponectin in mouse and human asthma (6,22,37). Further, the results from our longitudinal analyses are supported by our previous cross-sectional analyses (6).…”

Section: Discussionmentioning

confidence: 73%

“…The literature pertaining to the adiponectin-asthma association is conflicting and confusing. Five human studies have analyzed the association between serum adiponectin and odds of prevalent asthma, independent of obesity (6,(31)(32)(33)(34), of which three studies show no significant associations (32)(33)(34) (Table E3). These studies are limited by their smaller numbers of girls/women, modest effect sizes, and lower prevalence of asthma and obesity in populations outside the United States (32-34).…”

Section: Discussionmentioning

confidence: 99%

“…Murine studies have, however, shown that this association is bidirectional, whereby exogenous adiponectin attenuates airway changes of asthma and allergen-induced bronchoprovocation decreases adiponectin concentrations (22). Although current human data remain inconclusive, our previous cross-sectional study shows that low serum adiponectin concentrations are associated with increased odds for prevalent asthma among women and not men (6). The direction of the adiponectin-asthma association in women is, however, not established.…”

mentioning

confidence: 88%

“…It is now well established that asthma is related to adiposity, particularly among women. Adipokines, proteins produced by adipose tissue, may regulate systemic inflammation and play a role in asthma (4)(5)(6)(7). Adiponectin is one such adipokine with predominantly antiinflammatory effects.…”

mentioning

confidence: 99%

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Low Serum Adiponectin Predicts Future Risk for Asthma in Women

Sood¹,

Qualls

Schuyler³

et al. 2012

Am J Respir Crit Care Med

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Rationale: Our previous cross-sectional study showed that serum adiponectin is inversely associated with asthma among women. However, it is not known if serum adiponectin predicts future development of asthma or if asthma affects subsequent serum adiponectin concentrations among women. Objectives: To determine longitudinal association between serum adiponectin and incident asthma among women. Methods: We used data from examinations at Years 10, 15, and 20 of the Coronary Artery Risk Development in Young Adults (CARDIA) cohort. In our primary analysis, the association of CARDIA Year 15 serum adiponectin concentration with Year 20 incident asthma was evaluated. In our secondary analysis, the converse direction, that is, the association of CARDIA Year 10 prevalent asthma with Year 15 serum adiponectin, was evaluated, using logistic regression techniques. Measurements and Main Results: Our primary analysis included 1,450 women, mostly premenopausal. Multivariable analyses demonstrated that the lowest tertile of Year 15 serum adiponectin concentration (,7 mg/L) predicted significantly higher risk for incident asthma at Year 20 among women (odds ratio, 2.07; 95% confidence interval, 1.05, 4.10), and particularly among current smokers (interaction P ¼ 0.051). Further, low serum adiponectin was more important than body mass index in predicting the risk for incident asthma among women. We also showed that the converse relationship was not true; that is, Year 10 prevalent asthma did not predict Year 15 serum adiponectin concentrations in women. Conclusions: Serum adiponectin affects future risk for asthma in women and not vice versa. Measures that raise systemic adiponectin concentrations may lead to newer ways to prevent asthma among women, particularly among those who smoke.Keywords: incident asthma; obesity; adiponectin; adipokine; women In 2005, more than 21 million people in the United States were estimated to be affected by asthma, amounting to 7.6% of the total population (1). Between 1980 and 1996, the prevalence of, and morbidity trends related to, asthma increased in the United States (2, 3). It is now well established that asthma is related to adiposity, particularly among women. Adipokines, proteins produced by adipose tissue, may regulate systemic inflammation and play a role in asthma (4-7). Adiponectin is one such adipokine with predominantly antiinflammatory effects. Adiponectin inhibits proinflammatory cytokines and endothelial adhesion molecules and induces antiinflammatory cytokines (8-11). Further, adiponectin regulates the proliferation and function of inflammatory cells including NK cells and T lymphocytes (12, 13).Although visceral adipocytes are the most important source of adiponectin, serum adiponectin concentrations are reduced in obese subjects (14,15). One possible explanation is that hypoxia-related necrosis of adipocytes activates macrophages in obese subjects (16). These activated macrophages produce tumor necrosis factor-a and IL-6, which in turn may directly inhibit the local production o...

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Section: Discussionsupporting

confidence: 69%