Association Between Ascites and Clinical Findings in Patients with Acute Pancreatitis: A Retrospective Study

Zeng, Quan-Xiang; Wu, Zhenhua; Huang, Dong-Liang; Huang, Ye-Sheng; Zhong, Hao‐Jie

doi:10.12659/msm.933196

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…In addition, abdominal effusion partly contributed to intra-abdominal hypertension progression [41]. Zeng et al reported that patients with peritoneal effusion were at higher risk for severe disease and worse prognosis, and peritoneal effusion was a risk factor for local and systemic AP complications [42]. Furthermore, by identifying the process by which the MCTSI was established, we found that peritoneal effusion, whether before or after revision, would receive a higher severity score [15].…”

Section: Discussionmentioning

confidence: 73%

Establishment and Validation of Early Prediction Model for Hypertriglyceridemic Severe Acute Pancreatitis

Yi,

Zeng,

Lin

et al. 2023

Preprint

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Background The prevalence of hypertriglyceridaemia-induced acute pancreatitis (HTG-AP) is increasing due to improvements in living standards and dietary changes. However, at present, there is no clinical multifactor scoring system specific to HTG-AP. This study aimed to screen the predictors of hypertriglyceridemia severe acute pancreatitis (HTG-SAP) and combined several indicators to establish and verify a visual model for the early prediction of HTG-SAP. Methods The clinical data of 266 patients with HTG-SAP were analysed. Patients were classified into severe (n = 42) and non-severe (n = 224) groups according to the Atlanta classification criteria. Several statistical analyses, including one-way analysis, least absolute shrinkage with selection operator (LASSO) regression model and binary logistic regression analysis were used to evaluate the data. Result The univariate analysis found that several factors showed no statistically significant differences, including number of episodes of pancreatitis, abdominal pain score and several blood diagnostic markers, such as lactate dehydrogenase (LDH), serum calcium (Ca2+), C-reactive protein (CRP) and the incidence of pleural effusion, between the two groups (P < 0.000). LASSO regression analysis identified six candidate predictors: CRP, LDH, Ca2+, procalcitonin (PCT), ascites and Balthazar computed tomography (CT) grade. Binary logistic regression multivariate analysis showed that CRP, LDH, Ca2+, and ascites were independent predictors of HTG-SAP. The area under the curve (AUC) was 0.886, 0.893, 0.872, and 0.850, respectively. The AUC of the newly established HTG-SAP model was 0.960 (95% confidence interval: 0.936–0.983), which was higher than that of the bedside index for severity in acute pancreatitis, modified CT severity index, Ranson score and Japanese severity score (JSS) CT grade (AUC: 0.794, 0.796, 0.894 and 0.764, respectively). The differences were statistically significant (P < 0.01), except for the JSS prognostic indicators (P = 0.130). The Hosmer–Lemeshow test showed that the predictive results of the model were highly consistent with the actual situation (P > 0.05). The decision curve analysis plot suggested that clinical intervention can benefit patients when the model predicts that they are at risk for developing HTG-SAP. Conclusions CRP, LDH, Ca2+ and ascites are independent predictors of HTG-SAP. The prediction model constructed based on these indicators has a high accuracy, sensitivity, consistency and practicability in predicting HTG-SAP.

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Section: Discussionmentioning

confidence: 73%

Establishment and Validation of Early Prediction Model for Hypertriglyceridemic Severe Acute Pancreatitis

Yi,

Zeng,

Lin

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Establishment and validation of early prediction model for hypertriglyceridemic severe acute pancreatitis

Shuanglian,

Huiling,

Xunting

et al. 2023

Lipids Health Dis

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Background The prevalence of hypertriglyceridaemia-induced acute pancreatitis (HTG-AP) is increasing due to improvements in living standards and dietary changes. However, currently, there is no clinical multifactor scoring system specific to HTG-AP. This study aimed to screen the predictors of HTG-SAP and combine several indicators to establish and validate a visual model for the early prediction of HTG-SAP. Methods The clinical data of 266 patients with HTG-SAP were analysed. Patients were classified into severe (N = 42) and non-severe (N = 224) groups according to the Atlanta classification criteria. Several statistical analyses, including one-way analysis, least absolute shrinkage with selection operator (LASSO) regression model, and binary logistic regression analysis, were used to evaluate the data. Results The univariate analysis showed that several factors showed no statistically significant differences, including the number of episodes of pancreatitis, abdominal pain score, and several blood diagnostic markers, such as lactate dehydrogenase (LDH), serum calcium (Ca2+), C-reactive protein (CRP), and the incidence of pleural effusion, between the two groups (P < 0.000). LASSO regression analysis identified six candidate predictors: CRP, LDH, Ca2+, procalcitonin (PCT), ascites, and Balthazar computed tomography grade. Binary logistic regression multivariate analysis showed that CRP, LDH, Ca2+, and ascites were independent predictors of HTG-SAP, and the area under the curve (AUC) values were 0.886, 0.893, 0.872, and 0.850, respectively. The AUC of the newly established HTG-SAP model was 0.960 (95% confidence interval: 0.936–0.983), which was higher than that of the bedside index for severity in acute pancreatitis (BISAP) score, modified CT severity index, Ranson score, and Japanese severity score (JSS) CT grade (AUC: 0.794, 0.796, 0.894 and 0.764, respectively). The differences were significant (P < 0.01), except for the JSS prognostic indicators (P = 0.130). The Hosmer–Lemeshow test showed that the predictive results of the model were highly consistent with the actual situation (P > 0.05). The decision curve analysis plot suggested that clinical intervention can benefit patients when the model predicts that they are at risk for developing HTG-SAP. Conclusions CRP, LDH, Ca2+, and ascites are independent predictors of HTG-SAP. The prediction model constructed based on these indicators has a high accuracy, sensitivity, consistency, and practicability in predicting HTG-SAP.

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Application of exosomes in the diagnosis and treatment of pancreatic diseases

Han

Zhao

Yang³

et al. 2022

Stem Cell Res Ther

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Pancreatic diseases, a serious threat to human health, have garnered considerable research interest, as they are associated with a high mortality rate. However, owing to the uncertain etiology and complex pathophysiology, the treatment of pancreatic diseases is a challenge for clinicians and researchers. Exosomes, carriers of intercellular communication signals, play an important role in the diagnosis and treatment of pancreatic diseases. Exosomes are involved in multiple stages of pancreatic disease development, including apoptosis, immune regulation, angiogenesis, cell migration, and cell proliferation. Thus, extensive alterations in the quantity and variety of exosomes may be indicative of abnormal biological behaviors of pancreatic cells. This phenomenon could be exploited for the development of exosomes as a new biomarker or target of new treatment strategies. Several studies have demonstrated the diagnostic and therapeutic effects of exosomes in cancer and inflammatory pancreatic diseases. Herein, we introduce the roles of exosomes in the diagnosis and treatment of pancreatic diseases and discuss directions for future research and perspectives of their applications.

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Association Between Ascites and Clinical Findings in Patients with Acute Pancreatitis: A Retrospective Study

Cited by 4 publications

References 28 publications

Establishment and Validation of Early Prediction Model for Hypertriglyceridemic Severe Acute Pancreatitis

Establishment and Validation of Early Prediction Model for Hypertriglyceridemic Severe Acute Pancreatitis

Establishment and validation of early prediction model for hypertriglyceridemic severe acute pancreatitis

Application of exosomes in the diagnosis and treatment of pancreatic diseases

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