Association Between Arterial Stiffness and Blood Pressure Progression With Incident Hypertension: A Systematic Review and Meta-Analysis

Saz‐Lara, Alicia; Bruno, Rosa María; Cavero‐Redondo, Iván; Álvarez‐Bueno, Celia; Notario‐Pacheco, Blanca; Martínez‐Vizcaíno, Vicente

doi:10.3389/fcvm.2022.798934

Cited by 7 publications

(6 citation statements)

References 53 publications

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“…There is accruing evidence that vascular-aging measures can help improve cardiovascular-risk prediction [ 17 , 18 , 19 ] and detect those at high risk earlier [ 6 , 17 , 18 , 19 ]. However, despite increasing knowledge about its value and the technological advances in its measurement, its implementation in clinical practice is lagging.…”

Section: Discussionmentioning

confidence: 99%

Developing a Questionnaire on Knowledge, Perceptions and Application of Vascular-Aging Measurements

Triantafyllou

Elia

Park

et al. 2023

JCDD

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Background: Vascular age (VA) is independent and chronological age for assessing cardiovascular disease (CVD) risk. However, tools for the implementation of VA are currently lacking. We aimed to develop a questionnaire to assess the current knowledge gaps related to VA and barriers to its implementation in routine practice. Methods: Using a stepwise mixed-method approach, a quantitative questionnaire was constructed in four phases: (1) basic item generation and the development of a semi-qualitative questionnaire (SQQ); (2) dissemination to the VascAgeNet extended network and an analysis of the semi-qualitative questionnaire responses; (3) the development of a quantitative questionnaire (QQ); and (4) an assessment of the content and face validity and internal reliability in an additional sample. Results: Based on six main topics initially identified through an expert panel, a SQQ was developed and disseminated. Finally, a 22-item QQ was developed, with questions grouped around three main themes: knowledge of VA and its risk factors; perceptions and beliefs regarding the importance and contribution of VA to risk classification; and the application of VA measurements in clinical and research practice and its potential limitations (Cronbach’s alpha between 0.920 and 0.982 for all three categories). Conclusion: We report the development of a QQ on VA addressed to both clinicians and non-clinicians aiming to assess their knowledge, perceptions and application of VA measurements.

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Section: Discussionmentioning

confidence: 99%

Developing a Questionnaire on Knowledge, Perceptions and Application of Vascular-Aging Measurements

Triantafyllou

Elia

Park

et al. 2023

JCDD

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“…Studies have revealed a high prevalence of cardiovascular diseases and risk factors in COVID-19 patients [ 35 - 38 ]. Arterial stiffness is an important predictor of cardiovascular events and all-cause mortality [ 39 - 42 ]. Age, HTN, and other cardiovascular factors are associated with increased arterial stiffness, which, in combination with systemic inflammation, can worsen the course of COVID-19 [ 28 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Association of COVID-19 and Arterial Stiffness Assessed using Cardiovascular Index (CAVI)

Podzolkov,

Bragina,

Tarzimanova

et al. 2024

CHYR

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Background:: COVID-19 is characterized by an acute inflammatory response with the formation of endothelial dysfunction and may affect arterial stiffness. Studies of cardio-ankle vascular index in COVID-19 patients with considered cardiovascular risk factors have not been conducted. Objective:: The purpose of our study was to assess the association between cardio-ankle vascular index and COVID-19 in hospitalized patients adjusted for known cardiovascular risk factors. Methods:: A cross-sectional study included 174 people hospitalized with a diagnosis of moderate COVID-19 and 94 people without COVID-19. Significant differences in the cardio-ankle vascular index values measured by VaSera VS - 1500N between the two groups were analyzed using parametric (Student's t-criterion) and nonparametric (Mann-Whitney) criteria. Independent association between COVID-19 and an increased cardio-ankle vascular index ≥ 9.0 adjusted for known cardiovascular risk factors was assessed by multivariate logistic regression. Results:: There were significantly higher values of the right cardio-ankle vascular index 8.10 [7.00;9.40] and the left cardio-ankle vascular index 8.10 [6.95;9.65] in patients undergoing inpatient treatment for COVID-19 than in the control group – 7.55 [6.60;8.60] and 7.60 [6.60;8.70], respectively. A multivariate logistic regression model adjusted for age, hypertension, plasma glucose level, glomerular filtration rate and diabetes mellitus showed a significant association between increased cardio-ankle vascular index and COVID-19 (OR 2.41 [CI 1.09;5.30]). Conclusion:: Hospitalized patients with COVID-19 had significantly higher cardio-ankle vascular index values compared to the control group. An association between an increased cardio-ankle vascular index and COVID-19 was revealed, independent of age, hypertension, plasma glucose level, glomerular filtration rate and diabetes mellitus.

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“…Data from the Framingham Heart Study has shown that the prevalence of high aortic PWV (>10.7 m/s) was around 1% for individuals younger than 50 years old, but increased to about 38% for those aged between 60 and 69 years old, especially in women (5). Cross-sectional (6)(7)(8) and longitudinal (9)(10)(11) studies show PWV is an independent risk factor for metabolic and cardiovascular diseases (CVDs), as well as all-cause mortality. By comparison, less is known about the environmental and genetic risk factors that contribute to the adverse effects of AS, and how these may change with ageing (12).…”

Section: Introductionmentioning

confidence: 99%

Genetic and biomarker modulation of arterial stiffness change in the SardiNIA population cohort

Asefa,

Meirelles,

Lakatta

et al. 2024

Front. Epidemiol.

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Background and aimsArterial stiffness (AS), quantified by pulse wave velocity (PWV), arises due to impaired arterial elastic tissue and smooth muscle dysfunction. We aimed to examine the longitudinal association of genetic, lipid and inflammation biomarkers with PWV and how these associations may change with aging.Materials and methodsWe utilized genotype and four time-point biomarker data from the SardiNIA cohort [n = 6,301; mean baseline age 43.3 (SD 17.3); 58% females]. To investigate the association of PWV with genetic variants, lipid, and inflammation biomarkers, we employed linear mixed modeling, using age as the time scale. Biomarkers exhibiting significant longitudinal associations were categorized into tertiles and individuals within the second tertile or those with heterozygous alleles were excluded, leaving a cohort of 2,000 individuals. This cohort was further divided into four risk groups: low genetic and low biomarker (L-L), low genetic and high biomarker (L-H), high genetic and low biomarker (H-L), and high genetic and high biomarker risk (H-H). Subsequent analyses focused on these risk groups to assess their association to PWV with time.ResultsUsing the complete dataset, we found a significant longitudinal association of total cholesterol (TC), triglycerides (TG), fibrinogen (FGN), and total white blood cell count (TWBC) with PWV, all with p < 3.33 × 10−3. After grouping, individuals with homogeneous risk alleles of SNP rs3742207 and high baseline TG levels (H-H group) exhibited a 1.39-fold higher PWV (m/s) (95% CI, 1.17–1.64, p = 1.21 × 10−4) compared to the L-L group. Similarly, individuals in the H-H group of rs3742207-TWBC combination showed 1.75 times higher PWV (95% CI, 1.48–0.2.07, p = 1.01 × 10−10) compared to the L-L group. Similar patterns were observed for groups based on SNP rs7152623-TWBC risk. Furthermore, these associations became more pronounced with increasing age (p < 3.33 × 10−3).ConclusionThe longitudinal association of TG and TWBC biomarkers with PWV varied by SNPs rs3742207 and rs7152623 genotype. Further studies are warranted to investigate the function of genetics, lipids, and inflammation biomarkers on PWV change.

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Association Between Arterial Stiffness and Blood Pressure Progression With Incident Hypertension: A Systematic Review and Meta-Analysis

Cited by 7 publications

References 53 publications

Developing a Questionnaire on Knowledge, Perceptions and Application of Vascular-Aging Measurements

Developing a Questionnaire on Knowledge, Perceptions and Application of Vascular-Aging Measurements

Association of COVID-19 and Arterial Stiffness Assessed using Cardiovascular Index (CAVI)

Genetic and biomarker modulation of arterial stiffness change in the SardiNIA population cohort

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