Association between arterial pressure and coronary artery calcification

Mayer, Björn; Lieb, Wolfgang; Radke, Peter W.; Götz, Anika; Fischer, Marcus; Bäßler, Andrea; Doehring, Lars C.; Aherrahrou, Zouhair; Liptau, Henrike; Erdmann, Jeanette; Holmer, Stephan; Hense, Hans‐Werner; Hengstenberg, Christian; Schunkert, Heribert

doi:10.1097/hjh.0b013e328165cbb6

Cited by 20 publications

(49 citation statements)

References 28 publications

(39 reference statements)

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“…31,32 Among all the CVD risk factors detected on ABPM, PP and SBP are most strongly associated with angiographically detected coronary artery calcification. 33 Non-dipping, reverse dipping, nocturnal hypertension, nocturnal hypotension and autonomic failure are patterns that are easily recognized with ABPM, and with this recognition comes an opportunity for intervention and risk reduction. 34 The 7-day ABPM in this study used gender-and agematched reference standards.…”

Section: Discussionmentioning

confidence: 99%

Prediabetes is associated with abnormal circadian blood pressure variability

et al. 2008

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Blood pressure (BP) exhibits a circadian variation characterized by a morning increase, followed by a small postprandial valley and a deeper descent during nocturnal rest. Although abnormal 24-h variability (abnormal circadian variability (ACV)) predicts adverse cardiovascular disease (CVD) outcomes, a 7-day automatic ambulatory BP monitoring (ABPM) and subsequent chronobiologic analysis of the gathered data, permits identification of consistency of any abnormal circadian variation. To test whether normal overweight healthy men and women with prediabetes differed from subjects with normoglycemia in having ACV with a 7-day ABPM. Consent for a 7-day ABPM was obtained from subjects with family history of diabetes mellitus, who were participating in the screening phase for a randomized, double blind, placebo-controlled weight loss trial in prediabetics to prevent progression to diabetes mellitus. The automatic 7-day ABPM device recorded BP and heart rate every 30 min during the day and every 60 min during the night. Normoglycemic and prediabetic subjects matched for age, sex, race, BP, BMI, waist circumference and glycemic control, differed statistically significantly only in their fasting and/or 2-h postprandial serum glucose concentrations. Chronobiologically-interpreted 7-day ABPM uncovered no abnormalities in normoglycemics, whereas prediabetics had a statistically significantly higher incidence of high mean BP (MESOR-hypertension), excessive pulse pressure and/or circadian hyper-amplitude-tension (CHAT) (Po0.001). ACV detected with 7-day ABPM may account for the enhanced CVD risk in prediabetes. These findings provide a basis for larger-scale studies to assess the predictive value of 7-day ABPM over the long term.

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Section: Discussionmentioning

confidence: 99%

Prediabetes is associated with abnormal circadian blood pressure variability

et al. 2008

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“…The relationship between HT and CAD have been investigated by many researchers and coronary artery disease diagnosed with angiography has been shown to have a strong correlation with systolic blood pressure and pulse pressure (23). A study in Egypt found hypertension, unrelated to their ongoing treatment, in 17.3% of 658 patients with ED.…”

Section: Discussionmentioning

confidence: 99%

Is there a relationship between severity of coronary artery disease and severity of erectile dysfunction?

et al. 2013

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Introductıon:The correlation between erectile dysfunction (ED) and coronary artery disease has been emphasized and ED has been recognized as a potential independent risk factor and/or predictor of coronary artery disease (CAD). We evaluated the association between the number of occluded coronary arteries in myocardial infarction (MI) patients with the severity of ED, and investigated the influence of related risk factors in our study group. Materials and Methods: 183 male patients who underwent coronary angiography because of acute MI from November 2009 to May 2011 were included. Following the stabilization of patients after the treatment, each patient was evaluated for erectile functionality. Risk factors such as age, diabetes, smoking, waist circumference, hypertension, and hematologic parameters were recorded. Results: Among 183 patients with a mean age of 55.2 years who underwent coronary angiography due to acute MI, 100 (54.64%) had ED, while the ED rate was 45.36% (44/97) in cases of single-vessel disease, 64.5% (31/48) in cases of two-vessel disease, and 65.7% (25/38) in cases of three-vessel disease. The mean IIEF score was 24.2 ± 4.3, 20.4 ± 4.9 and 20.5 ± 4.2 for single or two or three-vessel disease, respectively. The presence of hypertension aggravated ED only in patients with three-vessel disease and increased total and LDL cholesterol levels in patients with single-vessel or two-vessel disease were accompanied by significantly decreasing IIEF scores. Conclusıon: The severity of ED correlated with the number of occluded vessels documented by coronary angiography, in male patients with acute myocardial infarction. In addition, the presence of hypertension had a significant influence over erectile function only in patients with three-vessel occlusion.

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“…This stepped strategy would recognize patients with CAC in advance and allow early therapeutic choice before coronary heart disease become symptomatic (24,26). In ESRD patients, standard radiographs, echocardiography, and pulse pressure have been found to be suitable procedures for predicting the presence of CAC (15)(16)(17)(18).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, in CKD patients, it is important to find simple and inexpensive tests for the preliminary screening. Standard radiographs, echocardiography, and pulse pressure may predict the presence of CAC in ESRD patients (15)(16)(17)(18).…”

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confidence: 99%

Pulse Pressure and Presence of Coronary Artery Calcification

Russo

Morrone

Brancaccio

et al. 2009

Clinical Journal of the American Society of Nephrology

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Background: Coronary calcification (CAC) is found in early stages of CKD. Pulse pressure (PP) predicts CAC in dialysis patients. This study evaluates the accuracy of PP in predicting CAC in patients not yet on dialysis (CKD patients).Methods: CKD patients (n ‫؍‬ 388) underwent coronary calcium score (CAC score) and abdominal x-ray (n ‫؍‬ 128) for estimating aorta calcification (AAC). Biochemistry and PP were measured every 3 and 6 months in patients with stage 4 to 5 and 2 to 3 CKD, respectively. The accuracy of PP and AAC was assessed by receiver operating characteristics analysis.Results: PP correlated with CAC score in the whole cohort and in patients with stages 2 to 3 and stages 4 to 5 CKD. PP >60 mmHg predicted CAC score >0 (OR: 2.14; P < 0.001), >100 (OR: 2.92; P < 0.001), >400 (OR: 6.17; P < 0.001) after multivariable adjustment. Area under the curve (AUC) was 0.626 for CAC score >0, 0.676 for score >100, and 0.746 for score >400. PP >60 mmHg reduced the rate of event-free survival. AAC was found in 58% of patients and correlated with CAC score. AUC was 0.628 for CAC score >0, 0.652 for score >100, 0.831 for score >400.Conclusion: PP may identify CKD patients with subclinical CAC who need further evaluation. Accuracy of PP and AAC is nearly similar in predicting CAC. High PP indicates vessel wall alterations leading to adverse outcome.

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Association between arterial pressure and coronary artery calcification

Cited by 20 publications

References 28 publications

Prediabetes is associated with abnormal circadian blood pressure variability

Prediabetes is associated with abnormal circadian blood pressure variability

Is there a relationship between severity of coronary artery disease and severity of erectile dysfunction?

Pulse Pressure and Presence of Coronary Artery Calcification

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