Association between ApoE polymorphism and hypertension: A meta-analysis of 28 studies including 5898 cases and 7518 controls

Shi, Jingwei; Liu, Yawen; Liu, Yunkai; Li, Yong; Qiu, Shuang; Bai, Yang; Gu, Yan; Luo, Jingjing; Cui, Heran; Li, Yan; Zhao, Qian; Zhang, Kaixin; Yi, Cheng

doi:10.1016/j.gene.2018.06.097

Cited by 25 publications

(23 citation statements)

References 49 publications

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“…Moreover, the complications of abnormal lipid levels (e.g., atherosclerosis, hypertension and/or diabetes, cardiovascular disease, CVD) were also observed to be associated with the APOE ε4 allele in the Asian population [23]. The APOE ε4 allele and the genotypes (ε3/ε4 and ε4/ε4) were associated with an increased risk of hypertension in different population studies, for example, in Asians and Caucasians [6]. Likewise, the individuals who carried the genotypes APOE ε3/ε4 and ε4/ε4, had high levels of LDL-C and increased blood pressure [6].…”

Section: Introductionmentioning

confidence: 97%

“…The genetic polymorphism of the APOE gene is mainly attributable to three alleles, ε2, ε3, and ε4. According to a meta-analysis, the allele frequencies of the APOE gene were found to differ in different ethnic populations [6]; for example, the APOE ε4 allele is particularly enriched in the indigenous populations of Central Africa (40%), Oceania (37%), Africa American (31%), and Australia (26%), and Caribbean-Hispanic (22%), but less common in the Mediterranean area or South China (<10%) [7,8]. However, there is a lack of studies on APOE ε4 allele frequency and its association with cholesterol phenotypes in the U.S. Hispanic population.…”

Section: Introductionmentioning

confidence: 99%

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APOE Gene Associated with Cholesterol-Related Traits in the Hispanic Population

Lozano

Padilla

Avila

et al. 2021

Genes

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Genetic variants in the apolipoprotein E (APOE) gene are associated with lipid metabolism and lipid-related traits in the non-Hispanic population. There have been limited studies regarding the association between the APOE gene and hypercholesterolemia in the Hispanic population; therefore, our aim for this study is to examine the APOE gene’s associations with cholesterol level and its related phenotypes. The APOE gene consists of three different alleles, ε2, ε3, and ε4, with ε4 being associated with dementia and cardiovascular diseases. A total of 1,382 subjects were collected from the Texas Alzheimer’s Research and Care Consortium (TARCC, N = 1320) and the Initial Study of Longevity and Dementia from the Rio Grande Valley (ISLD-RGV, N = 62). Questionnaires on demographics, medical history, and blood/saliva samples were collected and APOE genotypes were performed. We observed allele frequencies of the APOE ε3 (96.7%), ε4 (22.6%) and ε2 (6.8%) alleles, respectively. Multivariable logistic regression revealed a significant association between the APOE ε4 allele and hypercholesteremia (p = 1.8 × 10−4) in our studied Hispanic population. We prove for the first time, that the APOE ε4 allele increases the risk for hypercholesterol in Hispanics. Further research is needed to confirm and supports our current findings.

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

APOE Gene Associated with Cholesterol-Related Traits in the Hispanic Population

Lozano

Padilla

Avila

et al. 2021

Genes

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“…APOE cluster genes encode diverse functions: lipoproteins ( APOE , APOC1 , ‐ C2, ‐C4 ), inflammation ( RELB , TGFB1 ), metabolism ( IGFL1 , TOMM40 ), brain development (NTF4 ), reproduction via gonadotrophins ( CGB , LHB ), and viral resistance ( APOE , NECTIN2 ). Other than AD, the APOE cluster is associated with atherosclerosis and hyperlipidemia, 7 hypertension, 8,9 obesity, 10 and longevity 11–13 . Because only APOE has been considered for GxE interaction with air pollution for risk of accelerated cognitive decline and AD dementia, 1,2 we examined other APOE cluster genes for response to air pollution in rodent brains.…”

Section: Narrativementioning

confidence: 99%

The APOE gene cluster responds to air pollution factors in mice with coordinated expression of genes that differs by age in humans

Haghani

Thorwald

Morgan

et al. 2020

Alzheimer's & Dementia

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Little is known of gene–environment interactions for Alzheimer's disease (AD) risk factors. Apolipoprotein E (APOE) and neighbors on chromosome 19q13.3 have variants associated with risks of AD, but with unknown mechanism. This study describes novel links among the APOE network, air pollution, and age‐related diseases. Mice exposed to air pollution nano‐sized particulate matter (nPM) had coordinate responses of Apoe‐Apoc1‐Tomm40 in the cerebral cortex. In humans, the AD vulnerable hippocampus and amygdala had stronger age decline in APOE cluster expression than the AD‐resistant cerebellum and hypothalamus. Using consensus weighted gene co‐expression network, we showed that APOE has a conserved co‐expressed network in rodent and primate brains. SOX1, which has AD‐associated single nucleotide polymorphisms, was among the co‐expressed genes in the human hippocampus. Humans and mice shared 87% of potential binding sites for transcription factors in APOE cluster promoter, suggesting similar inducibility and a novel link among environment, APOE cluster, and risk of AD.

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“…The e3 variant is the most frequent allele (~77% in the general population), while e2 and e4 are less common, with occurrence rates of 7.8% and 15.1%, respectively [ 18 ]. APOE e4 presence is associated with several risk factors and diseases [ 19 , 20 , 21 , 22 ], including faster CD [ 2 , 23 ]. Homozygotes have the highest risk, followed by heterozygotes, implying that the effect of APOE e4 on CD is dose-dependent [ 17 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Can Physical Activity Reduce the Risk of Cognitive Decline in Apolipoprotein e4 Carriers? A Systematic Review

Perez-Lasierra

Casasnovas

Arbonés-Mainar

et al. 2021

IJERPH

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Physical activity (PA) reduces the risk of cognitive decline (CD) in the general population. However, little is known about whether the presence of the apolipoprotein E epsilon 4 allele (APOE e4) could modify this beneficial effect. The aim of this systematic review was to analyze and synthetize the scientific evidence related to PA levels and CD risk in cognitively healthy APOE e4 carriers. Four electronic databases were analyzed. Only original articles with longitudinal study design were selected to analyze the relationship between PA and CD in APOE e4 carriers. Five studies were included in the systematic review. All studies except one stated that PA is a protective factor against CD in APOE e4 carriers. Moreover, partial support was found for the hypothesis that a greater amount and intensity of PA are more beneficial in CD prevention. The results support the idea that PA is a protective factor against CD in APOE e4 carriers. Nevertheless, it would be necessary to carry out further studies that would allow these findings to be contrasted.

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Association between ApoE polymorphism and hypertension: A meta-analysis of 28 studies including 5898 cases and 7518 controls

Cited by 25 publications

References 49 publications

APOE Gene Associated with Cholesterol-Related Traits in the Hispanic Population

APOE Gene Associated with Cholesterol-Related Traits in the Hispanic Population

The APOE gene cluster responds to air pollution factors in mice with coordinated expression of genes that differs by age in humans

Can Physical Activity Reduce the Risk of Cognitive Decline in Apolipoprotein e4 Carriers? A Systematic Review

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