Association between apical periodontitis lesions and plasmatic levels of C‐reactive protein, interleukin 6 and fibrinogen in hypertensive patients

Vidal, Fábio; Fontes, Tatiana Vasconcellos; Marques, Fábio Vidal; Gonçalves, Lúcio Souza

doi:10.1111/iej.12567

Cited by 34 publications

(27 citation statements)

References 55 publications

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“…It has also been reported that IL-6 is a potential inducer of addressing molecules on the inflamed vessels [21]. Increased expression of the cytokine in the patients suffering from hypertension and CAD has been reported in the previous investigations [26]. Thus, it seems that IL-6 may be considered as a risk factor for hypertension and CAD.…”

Section: Discussionmentioning

confidence: 88%

Atorvastatin, Losartan and Captopril Lead to Upregulation of TGF-β, and Downregulation of IL-6 in Coronary Artery Disease and Hypertension

et al. 2016

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IntroductionCoronary artery disease (CAD) and hypertension are the main reasons of ischemic heart diseases (IHDs). Cytokines as the small glycoproteins are the main arm of immune system and manipulate all of the cardiovascular diseases. The aim of the current study was to examine the effects of treatment of hypertension and CAD on serum levels of IL-6, IL-8, TGF-β and TNF-α.Material and MethodsThis interventional study was performed on the patients with hypertension without CAD (group 1), hypertension and CAD (group 2), CAD but not hypertension (group 3) and without hypertension and CAD as controls (group 4). The patients received routine treatment for hypertension and CAD. Serum levels of IL-6, IL-8, TGF-β and TNF-α were analyzed in the groups treated with various drugs, using ELISA technique.ResultsWith regard to the medications, Atorvastatin, Losartan and Captopril were administered more in patients (groups 1, 2 and 3) than the patients without hypertension and CAD. The results revealed that serum levels of TGF-β and IL-6 were significantly increased and decreased, respectively, in the groups 1, 2 and 3 when compared to group 4. Serum levels of TGF-β were also increased in females in comparison to males in the group 4.DiscussionAccording to the results it seems that Atorvastatin, Losartan and Captopril have reduced inflammation in in vivo conditions via downregulation of IL-6 and upregulation of TGF-β.

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Section: Discussionmentioning

confidence: 88%

Atorvastatin, Losartan and Captopril Lead to Upregulation of TGF-β, and Downregulation of IL-6 in Coronary Artery Disease and Hypertension

et al. 2016

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“…High levels of IL-6 in AP seem to be correlated with symptomatic and active lesions [45]. IL-6 is an important pro-inflammatory biomarker and some recent studies aimed to correlate the expression in AP (as a reservoir of inflammatory cytokines) with blood levels in order to verify the relationship of these lesions with systemic inflammatory conditions, showing very conflicting results [3,[47][48][49].…”

Section: Cytokinesmentioning

confidence: 99%

Inflammatory profile of chronic apical periodontitis: a literature review

Braz‐Silva

Bergamini

Mardegan

et al. 2018

Acta Odontologica Scandinavica

149

129

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Apical periodontitis caused by root canal infection is the most frequent pathological lesion in the jaws, mainly manifested as periapical granulomas and cysts. Understanding of the formation and progression of apical periodontitis as well as the identification of inflammatory biomarkers can help increase the knowledge of pathogenic mechanisms, improve the diagnosis and provide support for different therapeutic strategies. The objective of the present article is to review inflammatory biomarkers such as cytokines, chemokines, inflammatory cells, neuropeptides, RANK/RANKL/OPG system and other inflammatory markers and to relate these systems to the development and progression of pathological conditions related to apical periodontitis.

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“…11 , 12 Periapical radiolucency due to apical periodontitis may contribute to this problem as it has been reported that apical periodontitis can precipitate a systemic inflammation activation in both healthy persons and patients with a variety of diseases. 13 , 14 However, it remains unknown whether this is also true for cirrhosis patients.…”

Section: Introductionmentioning

confidence: 99%

Presence and consequence of tooth periapical radiolucency in patients with cirrhosis

Grønkjær

Holmstrup²,

Schou

et al. 2016

HMER

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BackgroundPeriapical radiolucency is the radiographic sign of inflammatory bone lesions around the apex of the tooth. We determined the prevalence and predictors of periapical radiolucency in patients with cirrhosis and the association with systemic inflammation status and cirrhosis-related complications.MethodsA total of 110 cirrhosis patients were consecutively enrolled. Periapical radiolucency was defined as the presence of radiolucency or widening of the periapical periodontal ligament space to more than twice the normal width. Predictors of periapical radiolucency and the association with systemic inflammation markers and cirrhosis-related complications were explored by univariable and multivariable logistic regression analyses.ResultsPeriapical radiolucency was present in one or more teeth in 46% of the patients. Strong predictors were gross caries (odds ratio [OR] 3.12, 95% confidence interval [CI] 1.43–6.79) and severe periodontitis (OR 3.98, 95% CI 1.04–15.20). Also old age (OR 1.10, 95% CI 1.01–1.19) and smoking (OR 3.24, 95% CI 1.02–17.62) were predictors. However, cirrhosis etiology (alcoholic vs nonalcoholic) or severity (Model of End-Stage Liver Disease score) were not predictors. The patients with periapical radiolucency had higher C-reactive protein (15.8 mg/L vs 8.1 mg/L, P=0.02) and lower albumin contents (25 g/L vs 28 g/L, P=0.04) than those without. Furthermore, the patients with periapical radiolucency had a higher prevalence of cirrhosis-related complications such as ascites, hepatic encephalopathy, and/or variceal bleeding (46% vs 27%, P=0.05).ConclusionPeriapical radiolucency is often present as an element of poor oral health status and likely has an adverse clinical significance, which should motivate diagnostic and clinical attention to the findings.

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Association between apical periodontitis lesions and plasmatic levels of C‐reactive protein, interleukin 6 and fibrinogen in hypertensive patients

Cited by 34 publications

References 55 publications

Atorvastatin, Losartan and Captopril Lead to Upregulation of TGF-β, and Downregulation of IL-6 in Coronary Artery Disease and Hypertension

Atorvastatin, Losartan and Captopril Lead to Upregulation of TGF-β, and Downregulation of IL-6 in Coronary Artery Disease and Hypertension

Inflammatory profile of chronic apical periodontitis: a literature review

Presence and consequence of tooth periapical radiolucency in patients with cirrhosis

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