Association between Aortic Valve Sclerosis and Adverse Cardiovascular Events

Lucena, Cristiane Machado; Santos, Rodrigo Pires dos

doi:10.5935/abc.20150081

Cited by 2 publications

(2 citation statements)

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“…Valvular calcification and myocardial fibrosis precede the development of aortic stenosis and thereby myocardial hypertrophy as well as myocardial ischemia [6]. It was reported that genetic factors play important roles in valvular calcification [7], but the key gene mutations in valvular calcification is still unclear.…”

Section: Introductionmentioning

confidence: 99%

miRNA-mRNA crosstalk in myocardial ischemia induced by calcified aortic valve stenosis

Duan

Cao

Tang

et al. 2019

Aging

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Aortic valve stenosis is the most common cause of morbidity and mortality in valvular heart disease in aged people. Both microRNA (miRNA) and mRNA are potential targets for the diagnosis and therapeutic intervention of myocardial ischemia induced by calcified aortic valve stenosis (CAVS), with unclear mechanisms. Here, 3 gene expression profiles of 47 male participants were applied to generate shared differentially expressed genes (DEGs) with significant major biological functions. Moreover, 20 hub genes were generated by a Weighted Genes Co-Expression Network Analysis (WGCNA) and were cross-linked to miRNA based on miRanda/miRwalk2 databases. Integrated miRNA/mRNA analysis identified several novel miRNAs and targeted genes as diagnostic/prognostic biomarkers or therapeutic targets in CAVS patients. In addition, the clinical data suggested that myocardial hypertrophy and myocardial ischemia in CAVS patients are likely associated with hub genes and the upstream regulatory miRNAs. Together, our data provide evidence that miRNAs and their targeted genes play an important role in the pathogenesis of myocardial hypertrophy and ischemia in patients with CAVS.

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Section: Introductionmentioning

confidence: 99%

miRNA-mRNA crosstalk in myocardial ischemia induced by calcified aortic valve stenosis

Duan

Cao

Tang

et al. 2019

Aging

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“…В популяции старше 65 лет кальциноз аортального клапана (АК) присутствует у каждого четвертого, а частота аортального стеноза составляет 2-9% случаев, увеличиваясь до 48% у лиц старше 85 лет [1]. КБАК независимо от степени тяжести ассоциируется с риском возникновения инфаркта миокарда, нарушения мозгового крово обращения, сердечной недостаточности и внезапной смерти [2], а выраженный КАС, помимо этого, повышает риск желудочно-кишечных кровотечений (так называемый "синдром Хейда") [3].…”

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Cellular and molecular mechanisms of calcific aortic valve disease

Vanuyto E¹,

Байкулова

Боева³

2019

Russ J Cardiol

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The review provides current data on the pathogenesis of calcific aortic valve disease (CAVD) — a widespread disease with unfavorable prognosis. Currently, there are no effective therapeutic methods for the prevention and treatment of this pathology with the exception of valve replacement surgery. The role of genetic and hereditary factors in the occurrence of CAVD is considered, the leading pathogenetic mechanisms are described taking into account the stage of the disease. In particular, in the initiation phase of calcification, deposition of oxidized lipoproteins in the cusps and local inflammation plays the leading role. In the progression phase, active ectopic calcification dominates, similar to the process of bone formation. The study of the pathogenesis of CAVD seems appropriate taking into account the prospect of developing new effective therapeutic and prophylactic approaches.

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Association between Aortic Valve Sclerosis and Adverse Cardiovascular Events

Cited by 2 publications

References 5 publications

miRNA-mRNA crosstalk in myocardial ischemia induced by calcified aortic valve stenosis

miRNA-mRNA crosstalk in myocardial ischemia induced by calcified aortic valve stenosis

Cellular and molecular mechanisms of calcific aortic valve disease

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