Association between anxiety and metabolic syndrome: A systematic review and meta-analysis of epidemiological studies

Tang, Fang; Wang, Gang-Pu; Lian, Ying

doi:10.1016/j.psyneuen.2016.11.025

Cited by 92 publications

(72 citation statements)

References 46 publications

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“…The discrepancy may be mainly attributed to different screening instruments of anxiety in NHNES and WCH database (Generalized anxiety disorder module and Self-Rating Anxiety Scale respectively). As concerning the previous studies about the relation between anxiety and MetS, contradictory findings were observed and it was hard to draw a consistent conclusion 5 . Further prospective study is needed.…”

Section: Discussionmentioning

confidence: 91%

“…MetS has been reported to have association with anxiety and thyroid hormone 5,6 . However, all the related researches focus on either psychological condition or thyroid hormone independently.…”

Section: Discussionmentioning

confidence: 99%

“…As shown in Fig. 4, the 1st line is the standard scale compared to each downward line (2)(3)(4)(5)(6)(7), by which a specific score of each line could be calculated. Then sum of 6 lines (scores) will be put on the 8 th line as the total points, and projected to the last line, which stands for the possibility of MetS.…”

Section: Correlation Between Components Of Mets and Independent Risk mentioning

confidence: 99%

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Subclinical hypothyroidism and anxiety may contribute to metabolic syndrome in Sichuan of China: a hospital-based population study

Zhang

Luo

et al. 2020

Sci Rep

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the prevalence of Metabolic syndrome (MetS) in Sichuan of china has not yet been estimated. Meanwhile the association among anxiety, subclinical hypothyroidism (SCH) and MetS was less wellstudied. The data was retrieved retrospectively from Health Promotion Center of West China Hospital database between 2014 and 2017. Internal validation by randomizing into training and testing panel by 9:1 and external validation with National Health and Nutrition Examination Survey (NHNES) were conducted. 19006 subjects were included into analysis, and 3530 (18.6%) of them were diagnosed with MetS. In training panel, age, sex (male), SCH (presence), SAS score, alcohol (Sometimes & Usual) and smoking (Active) were identified as independent risk factors for MetS, which was confirmed in testing panel internally. NHNES data validated externally the association between free thyroxine (fT4) and MetS components. The C-indices of predicting MetS nomogram were 0.705 (95% CI: 0.696-0.714) and 0.728 (95% CI: 0.701-0.754) in training and testing panel respectively. In conclusion, MetS prevalence was 18.6% in Sichuan. SCH and anxiety may be associated with MetS independently. A risk scale-based nomogram with accurate and objective prediction ability was provided for check-up practice, but more cohort validation was needed.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Correlation Between Components Of Mets and Independent Risk mentioning

confidence: 99%

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Subclinical hypothyroidism and anxiety may contribute to metabolic syndrome in Sichuan of China: a hospital-based population study

Zhang

Luo

et al. 2020

Sci Rep

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“…More recently, Albert et al, [4] using a cross-sectional approximation, found that the prevalence of MS in a sample of patients with obsessive-compulsive disorder (OCD) is higher than those reported in the Italian general population. Additionally, in the last year, Tang and collaborators reported that anxiety has a significant positive association with MS using a meta-analytic approach [5]. In contrast with these findings, Hildrum et al, [6] did not find an association between anxiety and MS in a Norwegian cohort.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, in 2011, Linnville and collaborators [7] stated that the overall prevalence of MS was the same in repatriated prisoners of the Vietnam War with and without PTSD in comparison with a control group. Thus, it is clear that the information generated from human studies is not enough to clarify whether or not exists a relationship between MS and anxiety disorders [5] and the nature of this association.…”

Section: Introductionmentioning

confidence: 99%

Increased anxiety-like behavior is associated with the metabolic syndrome in non-stressed rats

et al. 2017

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Metabolic syndrome (MS) is a cluster of signs that increases the risk to develop diabetes mellitus type 2 and cardiovascular disease. In the last years, a growing interest to study the relationship between MS and psychiatric disorders, such as depression and anxiety, has emerged obtaining conflicting results. Diet-induced MS rat models have only examined the effects of high-fat or mixed cafeteria diets to a limited extent. We explored whether an anxiety-like behavior was associated with MS in non-stressed rats chronically submitted to a high-sucrose diet (20% sucrose in drinking water) using three different anxiety paradigms: the shock-probe/burying test (SPBT), the elevated plus-maze (EPM) and the open-field test (OFT). Behaviorally, the high-sucrose diet group showed an increase in burying behavior in the SPBT. Also, these animals displayed both avoidance to explore the central part of the arena and a significant increase in freezing behavior in the OFT and lack of effects in the EPM. Also, high-sucrose diet group showed signs of an MS-like condition: significant increases in body weight and body mass index, abdominal obesity, hypertension, hyperglycemia, hyperinsulinemia, and dyslipidemia. Plasma leptin and resistin levels were also increased. No changes in plasma corticosterone levels were found. These results indicate that rats under a 24-weeks high-sucrose diet develop an MS associated with an anxiety-like behavior. Although the mechanisms underlying this behavioral outcome remain to be investigated, the role of leptin is emphasized.

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The psychological burden associated with metabolic syndrome: Evidence from UK and US older adults

Robinson,

Daly,

Putra

2024

Obesity Science & Practice

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IntroductionWe examined the psychological burden associated with metabolic syndrome (MetSyn).MethodsWe used comparable longitudinal data of older adults (≥50 years) from the UK (English Longitudinal Study of Aging) and the US (Health and Retirement Study). We defined MetSyn based on biomarker assessments (e.g., blood pressure, impaired glycemic control). Using regression models, we tested a range of individual psychological outcomes (e.g., depressive symptoms) associated with MetSyn. We also examined whether these psychological outcomes may explain or moderate the link between MetSyn and non‐communicable diseases (NCDs).FindingsMetSyn was associated cross‐sectionally with a range of psychological outcomes, including depression, anxiety, loneliness, hopelessness, cynical hostility, social strain, negative affect and decreased positive affect, social support and purpose in life. There was no convincing evidence that psychological factors interacted with or explained (mediated) the relationship between MetSyn and increased risk of developing NCD over 10‐year follow‐ups.ConclusionsMetSyn and the psychological burden outcomes examined may have independent effects on NCD risk.

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Association between anxiety and metabolic syndrome: A systematic review and meta-analysis of epidemiological studies

Cited by 92 publications

References 46 publications

Subclinical hypothyroidism and anxiety may contribute to metabolic syndrome in Sichuan of China: a hospital-based population study

Subclinical hypothyroidism and anxiety may contribute to metabolic syndrome in Sichuan of China: a hospital-based population study

Increased anxiety-like behavior is associated with the metabolic syndrome in non-stressed rats

The psychological burden associated with metabolic syndrome: Evidence from UK and US older adults

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