Association Between Antithrombotic Treatments and Prognosis of Patients With Acute Pulmonary Thromboembolism in Japan

Ota, Masahiro; Nakamura, Mashio; Yamada, Norikazu; Yazu, Takahiro; Ishikura, Ken; Fujioka, Hirofumi; Isaka, Naoki; Nakano, Takeshi

doi:10.1253/circj.67.612

Cited by 12 publications

(2 citation statements)

References 32 publications

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“…It has been reported that even mild cases of PE with stable hemodynamics can have extensive residual DVT, and when a DVT advances centrally owing to insufficient treatment, recurrence of embolization becomes serious. 18) Using filters has been reported to be useful in reducing the mortality in acute PE. 2) As the recurrence of embolization of a residual thrombus may be fatal in intermediate-highrisk PE patients, using IVCF should be appropriately considered in accordance with the guidelines.…”

Section: Treatments Other Than Anticoagulant Therapy For Intermediatementioning

confidence: 99%

Administration of Direct Oral Anticoagulant Immediately after Unfractionated Heparin Bolus for the Treatment of Intermediate–High-Risk Pulmonary Thromboembolism

Hara

Watanabe

Miyazaki

et al. 2020

Annals of Vascular Diseases

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This study aims to evaluate the efficacy and safety of direct oral anticoagulants (DOACs) after unfractionated heparin (UFH) bolus for the treatment of intermediate-high-risk pulmonary embolism. Materials and Methods: On the basis of initial treatment, 81 patients were divided into two groups: DOAC after UFH bolus infusion group (group D; n=32) and conventional therapy group (group C; n=49). The frequency of recurrence of venous thromboembolism (VTE) and bleeding within 6 months were compared. In addition, hospitalization length and thrombus reduction rate in the pulmonary artery on computed tomography (CT) at the chronic phase were assessed. Results: Recurrence of VTE was found in one (3.1%) and three patients (6.1%) (P=1.00) in groups D and C, respectively, whereas no bleeding events was found in group D and 8.2% of patients in group C (P=0.15). Group D showed shorter hospitalization (7.2±2.3 days) than group C (15.7±9.9 days; P<0.001). In the subset of patients with serial CT assessment (group D, n=20; group C, n=38), almost all thrombus of pulmonary artery were disappeared and the thrombus reduction rates were similar between the two groups (group D, 99.5%; group C, 97.1%; P=0.59). Conclusion: DOAC administration immediately after UFH bolus treatment has the same efficacy and safety, whereas hospitalization days were significantly shorter than the conventional treatment group.

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Section: Treatments Other Than Anticoagulant Therapy For Intermediatementioning

confidence: 99%

Administration of Direct Oral Anticoagulant Immediately after Unfractionated Heparin Bolus for the Treatment of Intermediate–High-Risk Pulmonary Thromboembolism

Hara

Watanabe

Miyazaki

et al. 2020

Annals of Vascular Diseases

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“…Therefore, patients with out-of-hospital of PE should be thoroughly examined for permanent risk factors and should be carefully followed for recurrence, even while undergoing adequate anticoagulation therapy. 24 …”

Section: Differences In Prognosismentioning

confidence: 99%

Differences in the Clinical Course of Acute Massive and Submassive Pulmonary Embolism-In-Hospital Onset vs Out-of-Hospital Onset-

Yamamoto

Sato

Tajima

et al. 2004

Circ J

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Background Acute massive or submassive pulmonary embolism (PE) has high mortality, but the clinical course according to the location of onset (ie, in-hospital or out-of-hospital) is unknown. Methods and ResultsIn the present study 56 consecutive patients with acute massive or submassive PE were studied retrospectively and a comparison made of the clinical characteristics, and outcomes between in-hospital onset (Group A) and out-of-hospital onset (Group B). Patients in Group A (n=28) had more frequent comorbidities with hemodynamic instability (54% vs 4%, p<0.0001) and temporary risk factors (93% vs 11%, p<0.0001), whereas patients in Group B (n=28) had a longer duration of symptoms (median: 5.5 days vs 0.5 day; p<0.0001), and had higher systolic pulmonary artery pressure (63±17 mmHg vs 46±12 mmHg, p=0.0006). Although inhospital mortality did not differ between the 2 groups, the recurrence rate was higher in Group B (23% vs 0%, p=0.03).Conclusions Patients who had in-hospital onset of PE had mostly temporary risk factors, unstable hemodynamics and a lower recurrence rate compared with the cases of out-of-hospital onset. In cases of in-hospital onset, prompt diagnosis and suitable treatment is needed to prevent fatalities and cases of out-of-hospital onset should be followed carefully for recurrence. (Circ J 2004; 68: 988 -992)

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Novel percutaneous catheter thrombectomy in acute massive pulmonary embolism: Rotational bidirectional thrombectomy (ROBOT)

Yoshida

Inoue²,

Kawagoe³

et al. 2006

Cathet Cardio Intervent

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Association Between Antithrombotic Treatments and Prognosis of Patients With Acute Pulmonary Thromboembolism in Japan

Cited by 12 publications

References 32 publications

Administration of Direct Oral Anticoagulant Immediately after Unfractionated Heparin Bolus for the Treatment of Intermediate–High-Risk Pulmonary Thromboembolism

Administration of Direct Oral Anticoagulant Immediately after Unfractionated Heparin Bolus for the Treatment of Intermediate–High-Risk Pulmonary Thromboembolism

Differences in the Clinical Course of Acute Massive and Submassive Pulmonary Embolism-In-Hospital Onset vs Out-of-Hospital Onset-

Novel percutaneous catheter thrombectomy in acute massive pulmonary embolism: Rotational bidirectional thrombectomy (ROBOT)

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