Association Between Antibiotics in the First Year of Life and Celiac Disease

Sander, Stine Dydensborg; Andersen, Anne‐Marie Nybo; Murray, Joseph A.; Karlstad, Øystein; Husby, Steffen; Størdal, Ketil

doi:10.1053/j.gastro.2019.02.039

Cited by 75 publications

(41 citation statements)

References 39 publications

(44 reference statements)

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“…A causal relationship between the microbiota and CD has not been established, though the microbiome clearly has programming effects on the immune system through complex pathways 30 . Circumstantial evidence comes from studies indicating increased risk of CD after antibiotic use during infancy [31][32][33] , and from cross-sectional studies identifying specific bacteria in the duodenum at diagnosis 34,35 .…”

Section: Discussionmentioning

confidence: 99%

Maternal fibre and gluten intake during pregnancy and risk of childhood celiac disease: the MoBa study

Lund-Blix

Tapia

Mårild

et al. 2020

Sci Rep

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Maternal diet can influence the developing immune system of the offspring. We hypothesized that maternal fibre and gluten intake during pregnancy were associated with the risk of celiac disease in the child. In the Norwegian Mother, Father and Child Cohort Study (MoBa, n = 85,898) higher maternal fibre intake (median 29.5 g/day) was associated with a lower risk of celiac disease in the offspring (adjusted relative risk 0.90, 95% CI 0.83 to 0.98 per 10 g/d increase). Gluten intake during pregnancy (median 13.0 g/d) was associated with a higher risk of childhood CD (adjusted relative risk = 1.21, 95% CI 1.02 to 1.43 per 10 g/d increase). These results were largely unaffected by adjustment for the child’s gluten intake at 18 months. In an independent study of 149 mother/child dyads, maternal fibre intake did not predict concentrations of total or sub-types of short-chain fatty acids in repeated infant stool samples, or fecal microbiome diversity in the mother or child. Our results suggest that high fibre and low gluten intake during pregnancy could be protective factors for celiac disease, although the mechanism is unknown.

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Section: Discussionmentioning

confidence: 99%

Maternal fibre and gluten intake during pregnancy and risk of childhood celiac disease: the MoBa study

Lund-Blix

Tapia

Mårild

et al. 2020

Sci Rep

Self Cite

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“…Environmental factors including gluten intake [33,34] and infections in early life [35][36][37] have also been associated with increased CD risk. Other suggested, although controversial [38,39], risk factors include bacterial infections and frequent use of antibiotics [40,41]. Interestingly, the incidence has been reported to vary depending on socioeconomic circumstances [10], leading to the hypothesis that slight microbial exposure increases CD risk by driving immune reactions toward autoantigens and dietary components [42].…”

Section: Discussionmentioning

confidence: 99%

First-degree Relatives of Celiac Disease Patients Have Increased Seroreactivity to Serum Microbial Markers

et al. 2020

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Risk of celiac disease (CD) is increased in relatives of CD patients due to genetic and possible environmental factors. We recently reported increased seropositivity to anti-Saccharomyces cerevisiae (ASCA), Pseudomonas fluorescens-associated sequence (anti-I2) and Bacteroides caccae TonB-linked outer membrane protein (anti-OmpW) antibodies in CD. We hypothesized these markers also to be overrepresented in relatives. Seropositivity and levels of ASCA, anti-I2 and anti-OmpW were compared between 463 first-degree relatives, 58 untreated and 55 treated CD patients, and 80 controls. CD-associated human leukocyte antigen (HLA)-haplotypes and transglutaminase (tTGab) and endomysium (EmA) antibodies were determined. One or more of the microbial antibodies was present in 75% of relatives, 97% of untreated and 87% of treated CD patients and 44% of the controls. The relatives had higher median ASCA IgA (9.13 vs. 4.50 U/mL, p < 0.001), ASCA IgG (8.91 vs. 5.75 U/mL, p < 0.001) and anti-I2 (absorbance 0.74 vs. 0.32, p < 0.001) levels than controls. There was a weak, positive correlation between tTGab and ASCA (r = 0.31, p < 0.001). Seropositivity was not significantly associated with HLA. To conclude, seropositivity to microbial markers was more common and ASCA and anti-I2 levels higher in relatives of CD patients than controls. These findings were not associated with HLA, suggesting the role of other genetic and environmental factors.

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“…A large registry-based cohort study that included over 1.5 million children from Denmark and Norway found no association between the mode of delivery (cesarean section vs. vaginal birth) and the risk of diagnosed CD (43). Data collected from the same cohort indicated that exposure to systemic antibiotics in the first year of life was positively associated with diagnosed CD, with a dose-dependent relation between an increasing number of dispensed antibiotics and CD risk (44). However, a recent systematic review of two studies on prenatal and three studies on postnatal antibiotic exposure reported contradictory results and thus rather excluded an association between antibiotic use and the risk of developing CD (45), as already suggested by the TEDDY study (46).…”

Section: Early Eventsmentioning

confidence: 98%

Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity

et al. 2020

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Celiac disease (CD) affects a growing number of individuals worldwide. To elucidate the causes for this increase, future multidisciplinary collaboration is key to understanding the interactions between immunoreactive components in gluten-containing cereals and the human gastrointestinal tract and immune system and to devise strategies for CD prevention and treatment beyond the gluten-free diet. During the last meetings, the Working Group on Prolamin Analysis and Toxicity (Prolamin Working Group, PWG) discussed recent progress in the field together with key stakeholders from celiac disease societies, academia, industry and regulatory bodies. Based on the current state of knowledge, this perspective from the PWG members provides recommendations regarding clinical, analytical and legal aspects of CD. The selected key topics that require future multidisciplinary collaborative efforts in the clinical field are to collect robust data on the increasing prevalence of CD, to evaluate what is special about gluten-specific T cells, to study their kinetics and transcriptomics and to put some attention to the identification of the environmental agents that facilitate the breaking of tolerance to gluten. In the field of gluten analysis, the key topics are the precise assessment of gluten immunoreactive components in wheat, rye and barley to understand how these are affected by genetic and environmental factors, the comparison of different methods for compliance monitoring of gluten-free products and the development of improved reference materials for gluten analysis.

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Association Between Antibiotics in the First Year of Life and Celiac Disease

Cited by 75 publications

References 39 publications

Maternal fibre and gluten intake during pregnancy and risk of childhood celiac disease: the MoBa study

Maternal fibre and gluten intake during pregnancy and risk of childhood celiac disease: the MoBa study

First-degree Relatives of Celiac Disease Patients Have Increased Seroreactivity to Serum Microbial Markers

Recent Progress and Recommendations on Celiac Disease From the Working Group on Prolamin Analysis and Toxicity

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