Association between anti-human heat shock protein-60 and interleukin-2 with coronary artery calcium score

Damluji, Abdulla; Ramireddy, Archana; Al‐Damluji, Mohammed Salim; Marzouka, George R.; Otalvaro, Lynda; Viles-González, Juan F.; Dong, Chunming; Alfonso, Carlos; Hendel, Robert C.; Cohen, Mauricio G.; Moscucci, Mauro; Bishopric, Nanette H.; Myerburg, Robert J.

doi:10.1136/heartjnl-2014-306649

Cited by 15 publications

(22 citation statements)

References 30 publications

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“…Besides, RES increased the secretion of IL-2 in CD4 + T cells. IL-2 is a proinflammatory cytokine and the level of IL-2 may be close correlated with the development and progression of CVD [51,52]. But IL-2 can induce the development of Tregs, which protect against AS [53].…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Ameliorates Atherosclerosis Induced by High-fat Diet and LPS in ApoE-/- Mice and Inhibits the Activation of CD4+ T Cells

Zhou

Long

Sun

et al. 2020

Preprint

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Background: Atherosclerosis (AS), which characterized with the accumulation of lipids on the vessel wall, is the pathological basis of many cardiovascular diseases (CVD) and seriously threatens human health. Resveratrol (RES) has been reported to be benefit for AS treatment. This research aimed to observe the effects of RES on AS induced by high-fat diet (HFD) and LPS in ApoE-/- mice and investigate the underlying mechanism.Methods: ApoE-/- mice were fed with HFD companied with LPS to induce AS and RES was administrated for 20 weeks. Splenic CD4+ T cells were cultured and treated with anti-CD3/CD28 together with LPS, and RES was added. Serum lipids and the atherosclerotic areas of aortas were detected. The activation of CD4+ T cells were investigated both in vivo and in vitro and the expression of DNA methyltransferases (Dnmt) in CD4+ T cells were measured. Results: In vivo, administration of RES prevented HFD and LPS induced dysfunction of serum lipids including TC (total cholesterol), TG (triglyceride), LDL-C (low density lipoprotein cholesterol) and HDL-C (high density lipoprotein cholesterol), ameliorated the thickened coronary artery wall and decreased the areas of atherosclerotic lesion on aortas. Besides, RES decreased the number of CD4+ T cells in peripheral blood, decreased the expression of CD25 and CD44, but not affected the expression of L-selectin (CD62L). In vitro, RES decreased the expression of Ki67, CD25 and CD44 in CD4+ T cells. Moreover, RES increased the secretion of IL-2, IL-10 and TGF-β1, decreased IL-6. In addition, RES decreased both the mRNA and protein level of Dnmt1 and Dnmt3b in CD4+ T cells.Conclusion: These results indicated that RES ameliorated AS induced by HFD companied with LPS in ApoE-/- mice, inhibited the proliferation and activation of CD4+ T cells and regulated the expression of Dnmt1 and Dnmt3b.

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Section: Discussionmentioning

confidence: 99%

Resveratrol Ameliorates Atherosclerosis Induced by High-fat Diet and LPS in ApoE-/- Mice and Inhibits the Activation of CD4+ T Cells

Zhou

Long

Sun

et al. 2020

Preprint

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“…Serum interleukin-2 soluble receptor alpha (IL-2 sRα) concentration was determined by ultrasensitive ELISA (Quantikine Human IL-2 sRα Immunoassay; R&D Systems, Minneapolis, Minnesota, USA; CV 4.6–7.2%), 27 and the assay range was 31.20 – 2,000 pg/mL. IL-2 sRα may regulate IL-2-dependent processes and levels correlate with IL-2.…”

Section: Methodsmentioning

confidence: 99%

The relationship between smoking intensity and subclinical cardiovascular injury: The Multi-Ethnic Study of Atherosclerosis (MESA)

Rifai

DeFillippis

McEvoy³

et al. 2017

Atherosclerosis

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Background and aims Modern tobacco regulatory science requires an understanding of which biomarkers of cardiovascular injury are most sensitive to cigarette smoking exposure. Methods We studied self-reported current smokers from the Multi-Ethnic Study of Atherosclerosis. Smoking intensity was defined by number of cigarettes/day and urinary cotinine levels. Subclinical cardiovascular injury was assessed using markers of inflammation [high-sensitivity C-reactive protein (hsCRP), interleukin 6 & 2 (IL-2 & IL-6), tumor necrosis factor alpha (TNF-α)], thrombosis (fibrinogen, D-dimer, homocysteine), myocardial injury (troponin T; TnT), endothelial damage (albumin: creatinine ratio), and vascular function [aortic & carotid distensibility, flow-mediated dilation (FMD)]. Biomarkers were modeled as absolute and percent change using multivariable-adjusted linear regression models adjusted for cardiovascular risk factors and smoking duration. Results Among 843 current smokers, mean age was 58 (9) years, 53% were men, 39% were African American, mean number of cigarettes per day was 13 (10), and median smoking duration was 39 (15) years. Cigarette count was significantly associated with higher hsCRP, IL-6 and fibrinogen (β coefficients: 0.013, 0.011, 0.60 respectively), while In-transformed cotinine was associated with the same biomarkers (β coefficients: 0.12, 0.04, 5.3 respectively) and inversely associated with aortic distensibility (β coefficient: −0.13). There was a limited association between smoking intensity and homocysteine, D-dimer, and albumin:creatinine ratio in partially adjusted models only, while there was no association with IL-2, TNF-α, carotid distensibility, FMD, or TnT in any model. In percent change analyses, relationships were strongest with hsCRP. Conclusions Smoking intensity was associated with early biomarkers of CVD, particularly, markers of systemic inflammation. Of these, hsCRP may be the most sensitive.

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“…In the study performed by Stanya et al [46] in rats, data Tsao et al [6] ; El-Wakkad et al [11] ; Ricardo-Gonzalez et al [12] ; Damluji et al [13] ; Chang et al . [14] Antiinflammatory Increased  Restores the glucose homeostasis  Limits the inflammation Zhou et al [40] ; Kwon et al [41]; Stanya et al [42] …”

Section: Il-13mentioning

confidence: 96%

“…This inhibits the lipids accumulation in adipose tissue, resulting in decreased weight gain and body fat [6,[11][12][13][14] .…”

Section: Il-4mentioning

confidence: 99%

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What Is the Role of Inflammatory Mediators on Energy Metabolism?

2016

Inflamm Cell Signal

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The subclinical and low intensity inflammation, oxidative stress, high calorie and high fat diet patterns are striking features of the obesity. The adipose tissue, through its endocrine function, is associated with the cytokines secretion, such as: IL-4, IL-13, IL-15 and IFN-γ, which trigger metabolic changes and possibly modulate the energy metabolism by modifying the biochemical, anthropometric and body composition parameters. This review summarizes scientific evidences about the relationship between such cytokines and mediators which alter the energy metabolism, predisposing or preventing the obesity.

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Association between anti-human heat shock protein-60 and interleukin-2 with coronary artery calcium score

Abstract: Increased concentrations of inflammatory markers (IL-2 and anti-HSP60) are associated with an increased CAC at baseline and follow-up in healthy asymptomatic adults. Future studies should be carried out to assess its association with early development of atherosclerosis.

Cited by 15 publications

References 30 publications

Resveratrol Ameliorates Atherosclerosis Induced by High-fat Diet and LPS in ApoE-/- Mice and Inhibits the Activation of CD4+ T Cells

Resveratrol Ameliorates Atherosclerosis Induced by High-fat Diet and LPS in ApoE-/- Mice and Inhibits the Activation of CD4+ T Cells

The relationship between smoking intensity and subclinical cardiovascular injury: The Multi-Ethnic Study of Atherosclerosis (MESA)

What Is the Role of Inflammatory Mediators on Energy Metabolism?

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