Association between antecedent blood pressure, hypertension-mediated organ damage and cardiovascular outcome

Olesen, Thomas Bastholm; Pareek, Manan; Stidsen, Jacob V; Blicher, Marie K; Rasmussen, Susanne; Vishram-Nielsen, Julie K K; Maagaard, Louise; Olsen, Michael Hecht

doi:10.1080/08037051.2020.1735930

Cited by 7 publications

(8 citation statements)

References 26 publications

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“…Damage to cells caused by physical stress results in the uncontrolled release of ion-exchange neurotransmitters. 3 Neuronal activity-induced metabolic stress (lactate and free radicals) causes axonal damage (secondary axotomy). Cortical spreading depression (CSD) is an electrical process during the migraine aura.…”

Section: Discussionmentioning

confidence: 99%

“…2 Elevated blood pressure is a major risk factor for the development of hypertension-mediated organ damage (HMOD) and subsequent cardiovascular diseases. 3 Hypertension and diabetes mellitus are common coexisting conditions and increase the short-term as well as long-term risk of various cardiovascular complications including stroke, CAD (coronary arterial diseases), heart failure, atrial fibrillation, and peripheral vascular disease. 4 CASE A 75-year-old man with a history of uncontrolled hypertension and type II diabetes mellitus was admitted to the emergency department with typical chest pain 1 hour before admission along with nausea and vomiting.…”

Section: Introductionmentioning

confidence: 99%

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Non-ST Elevation Acute Coronary Syndrome (NSTEACS) as Hypertension-Mediated Organ Damage (HMOD) in Hypertensive Emergencies

Puspaseruni¹,

Rizka²,

Sakulat³

2023

Cermin Dunia Kedokteran

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Hypertensive emergencies are characterized by severe increases in blood pressure with evidence of hypertension-mediated organ damage (HMOD) and are associated with an increased risk of cardiovascular events, i.e. coronary heart disease (CHD) and mortality. Case: A 75-year-old man with typical chest pain with nausea and vomiting 1 hour before admission. Blood pressure was 200/100 mmHg, ECG showed T inversion in leads II, III, AVF, V1-V6 and prolonged QT interval, cardiomegaly on chest x-ray, and leukocytosis, hyperglycemia, and hypokalemia. The diagnoses were non-ST elevation acute coronary syndrome (NSTE-ACS), hypertensive emergency, and T2DM. Treatment in the ICCU consists of intravenous antihypertensive, antiplatelet, anticoagulant, statin, nitrate, insulin, and potassium chloride for electrolyte correction. The patient was admitted to the ICCU for further observation and management. Hipertensi emergensi ditandai dengan kenaikan tekanan darah yang sangat disertai bukti kerusakan organ yang progresif (hypertension-mediated organ damage - HMOD). Keadaan ini berkaitan dengan peningkatan risiko kejadian penyakit kardiovaskular, seperti penyakit jantung koroner bahkan kematian. Kasus: Seorang laki-laki usia 75 tahun dengan nyeri dada tipikal sejak 1 jam sebelum datang ke rumah sakit disertai mual dan muntah. Tekanan darah 200/100 mmHg, pada EKG didapatkan inversi T pada lead II, III, AVF, V1-V6, dan pemanjangan interval QT. Pada pemeriksaan X-ray dada didapatkan kardiomegali, hasil laboratorium menunjukkan leukositosis, hiperglikemi, dan hipokalemi. Pasien didiagnosis non-ST elevation acute coronary syndrome (NSTE-ACS), hipertensi emergensi, dan diabetes melitus tipe 2. Tata laksana di ICCU menggunakan anti-hipertensi intravena, anti-platelet, anti-koagulan, statin, nitrat, insulin, dan kalium klorida untuk koreksi elektrolit. Pasien dirawat di ICCU untuk observasi dan tata laksana lebih lanjut.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Non-ST Elevation Acute Coronary Syndrome (NSTEACS) as Hypertension-Mediated Organ Damage (HMOD) in Hypertensive Emergencies

Puspaseruni¹,

Rizka²,

Sakulat³

2023

Cermin Dunia Kedokteran

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“…Every year, 10.4 million people die of complications of hypertension worldwide [ 1 ]. Organ damage caused by hypertension and cardiovascular disease (CVD) are currently the main causes of death [ 2 ]. Due to the abnormal increase in arterial pressure, the coronary artery is more likely to experience increased local tensile stress, causing endothelial injury, the accumulation of lipid particles, induction of inflammatory reactions, and acceleration of the growth of plaques [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Predicting Coupled Herbs for the Treatment of Hypertension Complicated with Coronary Heart Disease in Real-World Data Based on a Complex Network and Machine Learning

Huan

Zhang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Hypertension and coronary heart disease are the most common cardiovascular diseases, and traditional Chinese medicine is applied as an auxiliary treatment for common cardiovascular diseases. This study is based on 3 years of electronic medical record data from the Affiliated Hospital of Shandong University of Traditional Chinese Medicine. A complex network and machine learning algorithm were used to establish a screening model of coupled herbs for the treatment of hypertension complicated with coronary heart disease. A total of 5688 electronic medical records were collected to establish the prescription network and symptom database. The hierarchical network extraction algorithm was used to obtain core herbs. Biological features of herbs were collected from public databases. At the same time, five supervised machine learning models were established based on the biological features of the coupled herbs. Finally, the K-nearest neighbor model was established as a screening model with an AUROC of 91.0%. Seventy coupled herbs for adjuvant treatment of hypertension complicated with coronary heart disease were obtained. It was found that the coupled herbs achieved the purpose of adjuvant therapy mainly by interfering with cytokines and regulating inflammatory and metabolic pathways. These results show that this model can integrate the molecular biological characteristics of herbs, preliminarily screen combinations of herbs, and provide ideas for explaining the value in clinical applications.

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“…Although these problems occur mainly in the elderly, there is some incidence in younger people [1]. The recognized risk factors for CVDs are hypertension, diabetes, hyperlipidemia, obesity, smoking, physical inactivity, and stress conditions as well as some genetic factors associated to an increased risk of CVDs [2][3][4][5][6][7]. However, not all cases present these factors and an undetermined portion of individuals develop symptoms early in life [8].…”

Section: Introductionmentioning

confidence: 99%

Helicobacter Pylori Infection Induces Intestinal Dysbiosis That Could Be Related to the Onset of Atherosclerosis

Avilés-Jiménez

2022

BioMed Research International

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Cardiovascular diseases represent one of the first causes of death around the world, and atherosclerosis is one of the first steps in the development of them. Although these problems occur mainly in elderly, the incidence in younger people is being reported, and an undetermined portion of patients without the classic risk factors develop subclinical atherosclerosis at earlier stages of life. Recently, both the H. pylori infection and the intestinal microbiota have been linked to atherosclerosis. The mechanisms behind those associations are poorly understood, but some of the proposed explanations are (a) the effect of the chronic systemic inflammation induced by H. pylori, (b) a direct action over the endothelial cells by the cytotoxin associated gene A protein, and (c) alterations of the lipid metabolism and endothelial dysfunction induced by H. pylori infection. Regarding the microbiota, several studies show that induction of atherosclerosis is related to high levels of Trimethylamine N-oxide. In this review, we present the information published about the effects of H. pylori over the intestinal microbiota and their relationship with atherosclerosis and propose a hypothesis to explain the nature of these associations. If H. pylori contributes to atherosclerosis, then interventions for eradication and restoration of the gut microbiota at early stages could represent a way to prevent disease progression.

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Association between antecedent blood pressure, hypertension-mediated organ damage and cardiovascular outcome

Cited by 7 publications

References 26 publications

Non-ST Elevation Acute Coronary Syndrome (NSTEACS) as Hypertension-Mediated Organ Damage (HMOD) in Hypertensive Emergencies

Non-ST Elevation Acute Coronary Syndrome (NSTEACS) as Hypertension-Mediated Organ Damage (HMOD) in Hypertensive Emergencies

Predicting Coupled Herbs for the Treatment of Hypertension Complicated with Coronary Heart Disease in Real-World Data Based on a Complex Network and Machine Learning

Helicobacter Pylori Infection Induces Intestinal Dysbiosis That Could Be Related to the Onset of Atherosclerosis

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