Association between ANRIL polymorphisms and risk of obsessive-compulsive disorder

Akbari, Mohammadarian; Hussen, Bashdar Mahmud; Eslami, Solat; Neishabouri, Seyedeh Morvarid; Ghafouri‐Fard, Soudeh

doi:10.1016/j.heliyon.2023.e14081

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Anril and The 9p21 Locus1

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2023

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“…Initially, the CDKN2A / ARF gene was found to be frequently inactivated or mutated in melanoma and other cancers, at least in part due to its ability to modulate the p53 axis [ 30 ]. Further investigations allowed researchers to link the 9p21 locus to various other abnormal situations, including atherosclerosis, T2D, Alzheimer’s disease, lupus erythematosus, epilepsy, glaucoma, obsessive compulsive disorder and sepsis [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ]. The specific genetic variants and mechanisms underlying these associations are complex and continue to be the subject of ongoing research.…”

Section: Anril and The 9p21 Locusmentioning

confidence: 99%

The Long Non-Coding RNA ANRIL in Cancers

Sanchez,

Lhuillier,

Grosjean

et al. 2023

Cancers

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ANRIL (Antisense Noncoding RNA in the INK4 Locus), a long non-coding RNA encoded in the human chromosome 9p21 region, is a critical factor for regulating gene expression by interacting with multiple proteins and miRNAs. It has been found to play important roles in various cellular processes, including cell cycle control and proliferation. Dysregulation of ANRIL has been associated with several diseases like cancers and cardiovascular diseases, for instance. Understanding the oncogenic role of ANRIL and its potential as a diagnostic and prognostic biomarker in cancer is crucial. This review provides insights into the regulatory mechanisms and oncogenic significance of the 9p21 locus and ANRIL in cancer.

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