Association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease susceptibility

Zhou, Tian-Biao; Yin, Sheng-Sheng; Qin, Yue

doi:10.1177/1470320312460898

Cited by 33 publications

(36 citation statements)

References 49 publications

(60 reference statements)

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“…4,[14][15][16] Dysfunction of ACE generation brought by the ACE I/D gene polymorphism might be considered as an important deterioration factor to be associated with sepsis susceptibility and sepsis progression. There was a rare genetic molecular marker to predict the onset of sepsis and sepsis progression.…”

Section: Discussionmentioning

confidence: 99%

“…3 The angiotensin-converting enzyme (ACE) insertion/ deletion (I/D) gene polymorphism is a 287-bp sequence of DNA in the intron 16 of the ACE gene, and the ACE gene includes either an insertion (I) allele or a deletion (D) allele that form three possible genotypes: II, ID or DD. 4,5 ACE, directly involved in the process of cell proliferation, differentiation, apoptosis and angiogenesis, 6 can convert angiotensin I into angiotensin II, and angiotensin II is the main effector molecule of the renin-angiotensin system, is pleiotropic, and is a mediator of the development and progression of diseases. 7 The ACE I/D gene polymorphism, correlating with circulating ACE concentration, might be implicated in the etiology of sepsis and has been investigated in some epidemiologic studies.…”

Section: Introductionmentioning

confidence: 99%

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RETRACTED: Association of the ACE I/D gene polymorphism with sepsis susceptibility and sepsis progression

Yang

Zhou

2015

J Renin Angiotensin Aldosterone Syst

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This article has been included in a multiple retraction: Chun-Hua Yang and Tian-Biao Zhou Association of the ACE I/D gene polymorphism with sepsis susceptibility and sepsis progression Journal of Renin-Angiotensin-Aldosterone System 1470320314568521, first published on February 3, 2015 doi:10.1177/1470320314568521 This article has been retracted at the request of the Editors and the Publisher. After conducting a thorough investigation, SAGE found that the submitting authors of a number of papers published in the Journal of the Renin-Angiotensin Aldosterone System (JRAAS) (listed below) had supplied fabricated contact details for their nominated reviewers. The Editors accepted these papers based on the reports supplied by the individuals using these fake reviewer email accounts. After concluding that the peer review process was therefore seriously compromised, SAGE and the journal Editors have decided to retract all affected articles. Online First articles (these articles will not be published in an issue) Wenzhuang Tang, Tian-Biao Zhou, and Zongpei Jiang Association of the angiotensinogen M235T gene polymorphism with risk of diabetes mellitus developing into diabetic nephropathy Journal of Renin-Angiotensin-Aldosterone System 1470320314563426, first published on December 18, 2014 doi:10.1177/1470320314563426 Tian-Biao Zhou, Hong-Yan Li, Zong-Pei Jiang, Jia-Fan Zhou, Miao-Fang Huang, and Zhi-Yang Zhou Role of renin-angiotensin-aldosterone system inhibitors in radiation nephropathy Journal of Renin-Angiotensin-Aldosterone System 1470320314563424, first published on December 18, 2014 doi:10.1177/1470320314563424 Weiqiang Zhong, Zongpei Jiang, and Tian-Biao Zhou Association between the ACE I/D gene polymorphism and T2DN susceptibility: The risk of T2DM developing into T2DN in the Asian population Journal of Renin-Angiotensin-Aldosterone System 1470320314566019, first published on January 26, 2015 doi:10.1177/1470320314566019 Tian-Biao Zhou, Xue-Feng Guo, Zongpei Jiang, and Hong-Yan Li Relationship between the ACE I/D gene polymorphism and T1DN susceptibility/risk of T1DM developing into T1DN in the Caucasian population Journal of Renin-Angiotensin-Aldosterone System 1470320314563425, first published on February 1, 2015 doi:10.1177/1470320314563425 Chun-Hua Yang and Tian-Biao Zhou Relationship between the angiotensinogen A1166C gene polymorphism and the risk of diabetes mellitus developing into diabetic nephropathy Journal of Renin-Angiotensin-Aldosterone System 1470320314566221, first published on February 1, 2015 doi:10.1177/1470320314566221 Chun-Hua Yang and Tian-Biao Zhou Association of the ACE I/D gene polymorphism with sepsis susceptibility and sepsis progression Journal of Renin-Angiotensin-Aldosterone System 1470320314568521, first published on February 3, 2015 doi:10.1177/1470320314568521 Articles published in an issue Guohui Liu, Tian-Biao Zhou, Zongpei Jiang, and Dongwen Zheng Association of ACE I/D gene polymorphism with T2DN susceptibility and the risk of T2DM developing into T2DN in a Caucasian popula...

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

RETRACTED: Association of the ACE I/D gene polymorphism with sepsis susceptibility and sepsis progression

Yang

Zhou

2015

J Renin Angiotensin Aldosterone Syst

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“…22 The increased level of ACE is associated with the pathogenesis of renal disease. ACE I/D polymorphism has been studied extensively in relation to ESRD 23,24 ; however, the findings of these studies remain controversial. Previous studies have indicated that a significant association exists between the DD gene and ESRD risk in Caucasians 25,26 and East Asians 27,28 ; however, this association is not observed in the Turkish population.…”

Section: Discussionmentioning

confidence: 99%

Impact of interaction of cigarette smoking with angiotensin-converting enzyme polymorphisms on end-stage renal disease risk in a Han Chinese population

Yang

Fang

et al. 2013

J Renin Angiotensin Aldosterone Syst

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Background: Several polymorphisms in the angiotensin-converting enzyme (ACE) and ACE2 genes are associated with the development of end-stage renal disease (ESRD). Certain genetic polymorphisms may modify the deleterious effects of environmental factors such as cigarette smoking and may also modify the inherited risk. We investigated the association of six ACE and ACE2 polymorphisms with ESRD to determine whether a relationship exists between gene-smoking interactions and ESRD. Materials and methods:We performed a case-control association study and genotyped 683 ESRD patients and 653 healthy controls. All subjects were genotyped for ACE (I/D, G2350A and A-240T) and ACE2 (G8790A, A1075G and G16854C) gene polymorphisms by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Results: Significant associations were observed between ACE I/D and G2350A polymorphisms and ESRD. There was no difference in ACE2 genotype distribution between ESRD patients and healthy controls. Haplotype analysis showed that DAA and DAT haplotypes were risk factors for ESRD. Moreover, a gene-environment interaction was observed between ACE I/D polymorphism and cigarette smoking. Conclusion: ACE I/D and ACE G2350A polymorphisms were associated with the development of ESRD. The interaction between ACE I/D polymorphism and smoking is also associated with an enhanced risk of ESRD.

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“…ESRD is an increasing problem worldwide and is a major health problem associated with very high morbidity and mortality 1,2 . Patients with ESRD must receive a kidney transplant or live on dialysis 1,3 . Reduction in serum 1,25 (OH) (2)D level plays an important role in the pathophysiology of altered bone and mineral metabolism among patients with advanced stages of chronic kidney disease (CKD).…”

Section: Introductionmentioning

confidence: 99%

Levels of vitamin D receptor and CYP24A1 in patients with end-stage renal disease

Zhou

Zhang

et al. 2016

Afr H. Sci.

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Abstract:Objective: This study was performed to detect the expression of vitamin D receptor (VDR) and cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1) in 24 end stage renal disease (ESRD) patients and 24 healthy controls. Method: In this study, 24 ESRD patients and 24 healthy controls were included. Results: In our study, the levels of VDR in patients with ESRD were reduced when compared with those from healthy controls (5.20±0.32 vs 8.59±1.03; P﹤0.01). However, the levels of CYP24A1 in ESRD patients were increased than those from healthy controls (50.18±21 vs 7.78±1.31; P﹤0.01). Correlation analysis showed that VDR levels were negatively correlated with CYP24A1 (r=-0.723; P﹤0.01). Conclusion: VDR levels were reduced and CYP24A1 levels were increased in patients with ESRD, and VDR levels were negatively correlated with CYP24A1.

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Association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end-stage renal disease susceptibility

Cited by 33 publications

References 49 publications

RETRACTED: Association of the ACE I/D gene polymorphism with sepsis susceptibility and sepsis progression

RETRACTED: Association of the ACE I/D gene polymorphism with sepsis susceptibility and sepsis progression

Impact of interaction of cigarette smoking with angiotensin-converting enzyme polymorphisms on end-stage renal disease risk in a Han Chinese population

Levels of vitamin D receptor and CYP24A1 in patients with end-stage renal disease

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