2021
DOI: 10.14423/smj.0000000000001293
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Association between Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers and Lung Cancer

Abstract: Objectives: Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are the most commonly prescribed antihypertensives, with prior studies identifying a possible association between long-term use and increased rates of lung cancer. This study evaluated this potential association in a large population using propensity matching.Methods: This was a population-based cohort study in a large healthcare system in three regions of the United States. Pairwise propensity score matching … Show more

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Cited by 6 publications
(9 citation statements)
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“…Based on the search strategy, 2400 records from the databases were screened, of which 392 duplicated records and 1976 records did not meet the inclusion criteria and were excluded. Finally, 11 clinical studies [12][13][14][23][24][25][26][27][28][29][30], including seven cohort studies [12,14,23,[26][27][28]30] and four case-control studies [13,24,25,29], conducted between 1988 and 2020 were included in the meta-analysis (Fig. 1).…”
Section: Search Resultsmentioning
confidence: 99%
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“…Based on the search strategy, 2400 records from the databases were screened, of which 392 duplicated records and 1976 records did not meet the inclusion criteria and were excluded. Finally, 11 clinical studies [12][13][14][23][24][25][26][27][28][29][30], including seven cohort studies [12,14,23,[26][27][28]30] and four case-control studies [13,24,25,29], conducted between 1988 and 2020 were included in the meta-analysis (Fig. 1).…”
Section: Search Resultsmentioning
confidence: 99%
“…The 11 studies comprised 11 study groups and 13 control groups. Four groups were extracted from two cohort studies [26,27] according to the different controls. The meta-analysis comprised a total of 13,061,226 patients, including 1,493,225 patients in the ACEI group and 11,568,001 patients in the non-ACEI group.…”
Section: Study Characteristicsmentioning
confidence: 99%
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“…In addition, treatment using angiotensin-converting enzyme inhibitors (ACEi) or angiotensin II receptor blockers (ARB) are typical in CKD patients [ 3 ]. These agents remain controversial for use against lung cancer, but several studies have indicated that they reduce the incidence of some types of cancer [ 21 , 22 ]. The effect of these agents on the incidence of HNC should be further studied.…”
Section: Discussionmentioning
confidence: 99%