Association Between Androgenic Alopecia and Coronary Artery Disease: A Cross-Sectional Study of Han Chinese Male Population

Wang, Yaxin; Chen, Xiaowen; Wang, Si-Bo; Gu, Lingfeng; Li, Yafei; Ma, Yao; Wang, Hao; Wang, Liansheng

doi:10.2147/ijgm.s326812

Cited by 5 publications

(10 citation statements)

References 38 publications

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“…30 In a recent study of 400 males, Wang et al reported that severe AGA was independently correlated to coronary artery disease (CAD) risk [odds ratio (OR): 2.11; 95% CI: 1.15-3.87)] and that AGA status (OR: 2.247; 95% CI: 1.396-3.617), severe AGA (OR: 2.360; 95% CI: 1.506-3.699) and early-onset AGA (OR: 3.474; 95% CI: 2.069-5.832) were all independently associated with the severity of coronary atherosclerosis. 27 Similarly, an association with confirmed CAD and AGA in young men (<45 years) has been found (OR: 2.70; 95% CI: 1.72-4.26). 38 Carotid atheroma has also been shown to be associated with AGA in both male (OR: 5.93; 95% CI: 1.5-22.9) and female patients (OR: 4.19; 95% CI: 1.05-16.7).…”

Section: Androgenetic Alopecia (Aga)mentioning

confidence: 77%

“…12 Similar results have been reported in more recent studies. [26][27][28] Elevated TG and depressed HDL are associated with the transition from atheroma to atherothrombosis. 29 A 5-year, 7000 participant study in Taiwan, including men and women, showed that moderate or severe AGA was associated with increased risk of mortality from DM [hazard ratio (HR): 2.97; 95% CI: 1.26-7.01].…”

Section: Androgenetic Alopecia (Aga)mentioning

confidence: 99%

“…A 2017 meta‐analysis of 19 studies (involving 2500 patients) investigating dyslipidemia and AGA found that total cholesterol [standardised mean difference (SMD) = 0.377; 95% confidence interval (CI): 0.182–0.572], triglycerides (TG) (SMD = 0.426; 95% CI: 0.164–0.688) and low‐density lipoprotein (LDL) (SMD = 0.450; 95% CI: 0.171–0.728) levels were significantly elevated and that high‐density lipoprotein (HDL) level was significantly decreased in patients with AGA as compared to healthy controls (SMD = −0.248; 95% CI: −0.472 to −0.023) 12 . Similar results have been reported in more recent studies 26–28 . Elevated TG and depressed HDL are associated with the transition from atheroma to atherothrombosis 29 …”

Section: Nonscarring Alopeciasmentioning

confidence: 99%

“…The aforementioned Taiwanese study demonstrated moderate or severe AGA was associated with increased risk of mortality from heart disease (adjusted HR: 2.28; 95% CI: 1.00–5.23) 30 . In a recent study of 400 males, Wang et al reported that severe AGA was independently correlated to coronary artery disease (CAD) risk [odds ratio (OR): 2.11; 95% CI: 1.15–3.87)] and that AGA status (OR: 2.247; 95% CI: 1.396–3.617), severe AGA (OR: 2.360; 95% CI: 1.506–3.699) and early‐onset AGA (OR: 3.474; 95% CI: 2.069–5.832) were all independently associated with the severity of coronary atherosclerosis 27 . Similarly, an association with confirmed CAD and AGA in young men (<45 years) has been found (OR: 2.70; 95% CI: 1.72–4.26) 38 .…”

Section: Nonscarring Alopeciasmentioning

confidence: 99%

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Cardiovascular risk in patients with scarring and nonscarring alopecias: Assessing the current state of evidence

Sally,

Robinson,

Orlow

et al. 2023

JEADV Clinical Practice

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Alopecia is traditionally classified into scarring and nonscarring subtypes, with etiopathologies ranging from androgen‐mediated to immuno‐inflammatory. Over 50% of men and almost 50% of women will experience some form of hair loss in their lifetime. Given this prevalence and the psychosocial significance of hair, understanding the pathophysiology and comorbidities of different types of hair loss is imperative. Other proinflammatory dermatologic disorders, such as psoriasis, are recognised to have systemic manifestations including an increased risk of cardiovascular (CV) disease, and are now considered CV risk‐enhancing conditions. With increased recognition of the importance of systemic inflammation in promoting atherosclerosis, high prevalence, and improved treatment strategies, there is increased interest in establishing whether a similar association between alopecia and cardiovascular disease (CVD) exists. In this manuscript, we aim to review the current literature regarding CV risk in androgenic alopecia (AGA) and alopecia areata (AA). Additionally, we review the literature for cicatricial alopecias and highlight the need for more research into their potential associations with CV risk. Evidence from the identified AGA publications suggests an association of AGA with CV risk factors including hypertension, dyslipidemia, and insulin resistance, as well as with coronary artery disease. For AA, most of the identified studies found an association between AA and CV risk, though the relationships were not always statistically significant. Research on cicatricial alopecias and CV risk is limited and often contradictory. There is great need for more studies regarding the association between various types of alopecia and the development of CVD, and potential mechanisms. Particularly needed are more studies of cicatricial alopecias and potential associated CV risk. While some literature suggests that patients with alopecia have an increased risk of CVD, the lack of concrete evidence represents a notable gap in our current understanding.

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Section: Androgenetic Alopecia (Aga)mentioning

confidence: 77%

Section: Androgenetic Alopecia (Aga)mentioning

confidence: 99%

Section: Nonscarring Alopeciasmentioning

confidence: 99%

Section: Nonscarring Alopeciasmentioning

confidence: 99%

See 2 more Smart Citations

Cardiovascular risk in patients with scarring and nonscarring alopecias: Assessing the current state of evidence

Sally,

Robinson,

Orlow

et al. 2023

JEADV Clinical Practice

View full text Add to dashboard Cite

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“…Moreover, the prevalence of family history of cardiovascular disease in the men and women AGA groups was significantly higher than that in the control group [ 62 ]. Wang Ya-Xin’s research further found that AGA status (OR 2.247; 95% CI 1.396–3.617, P = 0.001), severe AGA (OR 2.360; 95% CI 1.506–3.699, P < 0.001), and early onset AGA (OR 3.54%; 95% CI 2.069–5.832, P < 0.001) were independently correlated with the severity of coronary atherosclerosis [ 63 ]. A meta-analysis revealed that the serum total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels in the AGA group were significantly higher than those in the control group, and the standardized mean differences were 0.377 (95% CI 0.182–0.572, P < 0.001), 0.426 (95% CI 0.164–0.688, P = 0.001), and 0.450 (95% CI 0.171–0.728, P = 0.002), respectively [ 64 ], which further confirmed the results of previous studies.…”

Section: Cardiovascular Diseasesmentioning

confidence: 99%

Comorbidities in Androgenetic Alopecia: A Comprehensive Review

Chen

Xie

Zhang

et al. 2022

Dermatol Ther (Heidelb)

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Androgenetic alopecia is the most common form of hair loss, affecting 85% of men and 40% of women. Androgenetic alopecia is a disease caused by multiple factors, such as genetics, hormones, and systemic diseases; however, the exact cause remains undetermined. Recent studies have found that it is associated with a high incidence of endocrine diseases and other comorbidities. It may not only be a skin disease but also an early signal of underlying systemic diseases. Effective management requires timely diagnosis and treatment initiation. However, in current clinical practice, androgenetic alopecia is still not fully understood or treated. Recognizing the true physical, social, and emotional burden of androgenic alopecia, as well as its associated comorbidities, is the first step in improving the prognosis of affected patients. This review aimed to gather the known pathological factors and provide a reference for clinical physicians to understand androgenetic alopecia and its comorbidities in depth, thereby enabling early recognition of the underlying systemic diseases and providing timely treatment.

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Factors associated with early-onset androgenetic alopecia: A scoping review

Liu,

Wariboko,

et al. 2024

PLoS ONE

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Background Early-onset androgenetic alopecia (AGA) has been associated with various chronic conditions, including metabolic syndrome (MetS). Gaining a deep understanding of early-onset AGA may enable earlier intervention in individuals at high risks. This scoping review aims to explore the risk factors and etiology, associated conditions, and adverse effects on wellbeing in early-onset AGA. Methods Electronic literature searches were conducted in MEDLINE, EMBASE and CENTRIAL. Eligible studies included case-control, cohort, cross-sectional, and meta-analysis studies. Selected studies needed to clearly define early-onset AGA cases or include only cases starting before the age of 40 and compare them with appropriate controls. The exclusion criteria comprised editorials, commentaries, case series, and non-systematic reviews, among others. Data extraction involved collecting study characteristics, methodologies, main outcomes, and findings. Descriptive tables were used to summarize key information and relevant variables when necessary. Results Among the 65 eligible articles, 67.69% were case-control studies and 78.46% evaluated only male patients. “Early-onset” was defined as cases developing before the age of 30 years in 43.08% of the studies. The Hamilton–Norwood scale was the most frequently used method for evaluating the severity of alopecia in men (69.23%). Reported risk factors for early-onset AGA included a family history of AGA, cigarette smoking, unhealthy dietary habits, and a high body mass index. Early-onset AGA may also be associated with hormonal profiles, 5α-reductase enzyme activity, androgen receptor genes, and some susceptibility loci. Comorbidities investigated included MetS, cardiovascular disease, insulin resistance, dyslipidemia, and Parkinson’s disease. Men with early-onset AGA may have reduced treatment efficacy with drug like rosuvastatin, metformin or lisinopril for dyslipidemia, prediabetes, or hypertension. Additionally, young men with AGA tended to suffer from psychological issues such as anxiety and low self-esteem compared to those without hair loss. Conclusion Early-onset AGA is a complex condition with various risk factors and etiology, associated comorbidities, and potential implications for treatment response and psychological health.

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Association Between Androgenic Alopecia and Coronary Artery Disease: A Cross-Sectional Study of Han Chinese Male Population

Cited by 5 publications

References 38 publications

Cardiovascular risk in patients with scarring and nonscarring alopecias: Assessing the current state of evidence

Cardiovascular risk in patients with scarring and nonscarring alopecias: Assessing the current state of evidence

Comorbidities in Androgenetic Alopecia: A Comprehensive Review

Factors associated with early-onset androgenetic alopecia: A scoping review

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