Association Between Ambient Air Pollution and Cardiac Morpho-Functional Phenotypes

Aung, Nay; Sanghvi, Mihir M.; Zemrak, Filip; Lee, Aaron M.; Paiva, José Miguel; Thomson, Ross; Fung, Kenneth; Khanji, Mohammed Y; Lukaschuk, Elena; Carapella, Valentina; Kim, Young Jin; Munroe, Patricia B.; Neubauer, Stefan; Petersen, Steffen E.

doi:10.1161/circulationaha.118.034856

Cited by 79 publications

(44 citation statements)

References 46 publications

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“…Altered cardiac remodelling associated with air pollution has also been recently identified in humans. In a large asymptomatic population, with no prevalent CVD, prior exposure to PM 2.5 (specific PAHs were not described) was associated with increased left and right ventricular end-diastolic volume and end-systolic volume (Aung et al 2018). A comprehensive mechanistic study by Wold et al (2012) further demonstrated that long-term (9 months) PM exposure was associated with cardiac hypertrophy, changes in cardiac myocyte phenotype and impaired cardiac contractility.…”

Section: Figure 4 Pah and Ec Coupling In Cardiac Myocytesmentioning

confidence: 99%

“…Similarly, a ß20% increase in stroke incidence has been observed in various European countries which met their air quality standards, indicating that current standards may not be sufficient . Concern for current air quality standards was bolstered by Aung et al (2018), who showed correlations between UK addresses, ambient air quality data (at levels within current UK air quality standards) and biventricular dilatation that is suggestive of detrimental cardiac remodelling.…”

Section: Airborne Particulate Matter and Human Health Risksmentioning

confidence: 99%

“…In a large asymptomatic population, with no prevalent CVD, prior exposure to PM 2.5 (specific PAHs were not described) was associated with increased left and right ventricular end‐diastolic volume and end‐systolic volume (Aung et al . ). A comprehensive mechanistic study by Wold et al .…”

Section: Introductionmentioning

confidence: 97%

“…Concern for current air quality standards was bolstered by Aung et al . (), who showed correlations between UK addresses, ambient air quality data (at levels within current UK air quality standards) and biventricular dilatation that is suggestive of detrimental cardiac remodelling.…”

Section: Introductionmentioning

confidence: 98%

See 3 more Smart Citations

Polyaromatic hydrocarbons in pollution: a heart‐breaking matter

Marris

Kompella

Miller

et al. 2020

The Journal of Physiology

123

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Air pollution is associated with detrimental effects on human health, including decreased cardiovascular function. However, the causative mechanisms behind these effects have yet to be fully elucidated. Here we review the current epidemiological, clinical and experimental evidence linking pollution with cardiovascular dysfunction. Our focus is on particulate matter (PM) and the associated low molecular weight polycyclic aromatic hydrocarbons (PAHs) as key mediators of cardiotoxicity. We begin by reviewing the growing epidemiological evidence linking air pollution to cardiovascular dysfunction in humans. We next address the pollution‐based cardiotoxic mechanisms first identified in fish following the release of large quantities of PAHs into the marine environment from point oil spills (e.g. Deepwater Horizon). We finish by discussing the current state of mechanistic knowledge linking PM and PAH exposure to mammalian cardiovascular patho‐physiologies such as atherosclerosis, cardiac hypertrophy, arrhythmias, contractile dysfunction and the underlying alterations in gene regulation. Our aim is to show conservation of toxicant pathways and cellular targets across vertebrate hearts to allow a broad framework of the global problem of cardiotoxic pollution to be established. AhR; Aryl hydrocarbon receptor. Dark lines indicate topics discussed in this review. Grey lines indicate topics reviewed elsewhere.

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Section: Figure 4 Pah and Ec Coupling In Cardiac Myocytesmentioning

confidence: 99%

Section: Airborne Particulate Matter and Human Health Risksmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 98%

See 2 more Smart Citations

Polyaromatic hydrocarbons in pollution: a heart‐breaking matter

Marris

Kompella

Miller

et al. 2020

The Journal of Physiology

123

View full text Add to dashboard Cite

show abstract

“…Epidemiological studies from Western countries have suggested that elevated ambient particulate matter <2.5 mm (PM 2.5 ) in aerodynamic diameter are consistently associated with adverse cardiovascular events or even mortality [1]. The suggested mechanism is that these events are associated with various systemic inflammatory responses after inhalation [2][3][4]. Current air quality standards in the USA and European societies are based on a 3-year average of the annual arithmetic means of PM 2.5 concentration [5,6], but clear evidence of a threshold PM 2.5 concentration associated with increased risks of cardiovascular or all-cause mortality is lacking [1,7,8].…”

Section: Introductionmentioning

confidence: 99%

Long-term fine particulate matter exposure and cardiovascular mortality in the general population: a nationwide cohort study

Kim

Yang

Lee

et al. 2020

Journal of Cardiology

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A B S T R A C TBackground: Although eastern Asian countries are exposed to high levels of air pollution, the impact of long-term exposures to fine particulate matter (PM 2.5 ) air pollution on all-cause and cardiovascular mortality is not well identified. We assessed the relationship between long-term PM 2.5 exposure and allcause/cardiovascular mortalities. Methods: We included 436,933 subjects who received national health examinations from the Korean National Health Insurance Service-based National Sample Cohort. We matched subjects' residentialaddress areas with hourly-measurements of PM 2.5 concentration data. We estimated the risk of mortality with average PM 2.5 exposure during the study period using a Cox proportional-hazards model. Results: During 1,683,271 personÁyears, all-cause and cardiovascular mortalities were observed in 6432 and 1603 subjects (382 and 95 per 100,000 personÁyears, respectively). An increase in 10 mg/m 3 in PM 2.5 was associated with increases in all-cause and cardiovascular mortalities by 3.4 % [2.7-4.1] and 4.7 % [3.6-5.8], respectively (each p < 0.001). PM 2.5 was linearly and significantly correlated with these all-cause and cardiovascular mortalities above 18 mg/m 3 of PM 2.5 (p < 0.001), but it was not significant below 18 mg/m 3 of PM 2.5 . To investigate the specific PM 2.5 concentration for raising cardiovascular mortality more, we analyzed the sensitivities/specificities for different PM 2.5 levels, and 18 mg/m 3 showed the highest Youden's index (sensitivity + specificity-1) with c-index of 0.85 (0.84-0.86). PM 2.5 effect on all-cause mortality was more profound in subjects with previous myocardial infarction compared to the opposite population. Conclusions: In the Korean general population exposed to high-air pollution, long-term PM 2.5 exposure was linearly associated with increased risk for all-cause and cardiovascular mortality, especially above 18 mg/m 3 of PM 2.5 .

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Pulmonary vascular disease, environmental pollution, and climate change

Lichtblau,

Reimann,

Piccari

2024

Pulm. circ.

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Pollution and climate change constitute a combined, grave and pervasive threat to humans and to the life‐support systems on which they depend. Evidence shows a strong association between pollution and climate change on cardiovascular and respiratory diseases, and pulmonary vascular disease (PVD) is no exception. An increasing number of studies has documented the impact of environmental pollution and extreme temperatures on pulmonary circulation and the right heart, on the severity and outcomes of patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension (PH), on the incidence of pulmonary embolism, and the prevalence and severity of diseases associated with PH. Furthermore, the downstream consequences of climate change impair health care systems' accessibility, which could pose unique obstacles in the case of PVD patients, who require a complex and sophisticated network of health interventions. Patients, caretakers and health care professionals should thus be included in the design of policies aimed at adaptation to and mitigation of current challenges, and prevention of further climate change. The purpose of this review is to summarize the available evidence concerning the impact of environmental pollution and climate change on the pulmonary circulation, and to propose measures at the individual, healthcare and community levels directed at protecting patients with PVD.

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Association Between Ambient Air Pollution and Cardiac Morpho-Functional Phenotypes

Abstract: Supplemental Digital Content is available in the text.

Cited by 79 publications

References 46 publications

Polyaromatic hydrocarbons in pollution: a heart‐breaking matter

Polyaromatic hydrocarbons in pollution: a heart‐breaking matter

Long-term fine particulate matter exposure and cardiovascular mortality in the general population: a nationwide cohort study

Pulmonary vascular disease, environmental pollution, and climate change

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