Association between altered physical activity and neurocognitive function among people with schizophrenia: A minimum 6-months' follow-up study

Kurebayashi, Yusuke; Otaki, Junichi

doi:10.1016/j.comppsych.2017.06.001

Cited by 10 publications

(11 citation statements)

References 26 publications

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“…Aerobic exercise has been shown to improve both "positive symptoms" of schizophrenia, including delusions and hallucinations, and "negative symptoms, " including cognitive inability and emotion blunt (Beebe et al, 2005;Duraiswamy et al, 2007;Vancampfort et al, 2011Vancampfort et al, , 2017Scheewe et al, 2013;Firth et al, 2017;Kurebayashi and Otaki, 2017). Since negative symptoms are almost not amenable with antipsychotic drug treatment (Fusar-Poli et al, 2015;Leucht et al, 2017), non-pharmacological interventions, including aerobic exercise and enriched environment, are needed to achieve better outcomes.…”

Section: Discussionmentioning

confidence: 99%

Parvalbumin Interneuron Activation-Dependent Adult Hippocampal Neurogenesis Is Required for Treadmill Running to Reverse Schizophrenia-Like Phenotypes

Song

2020

Front. Cell Dev. Biol.

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Physical exercise can alleviate some of the schizophrenia symptoms in patients, the mechanisms, however, are still unclear. To investigate whether the GABAergic interneuron involved in the therapeutic effect of treadmill running on schizophrenia, the parvalbumin (PV)-positive GABAergic interneurons in the dentate gyrus (DG) was specifically activated or abolished and the effects were evaluated. In the MK801induced schizophrenia-like animal model, we found:(1) Treadmill running rescued the schizophrenia-related behavioral phenotypes, promoted the adult hippocampal neurogenesis, and increased the dendrite number and complexity of newborn neurons. (2) Treadmill running increased the number of PV-positive interneurons in the DG; genetic ablation of these interneurons reduced adult neurogenesis and abolished the effect of treadmill running on the schizophrenia-related behaviors. Consistently, chemogenetic activation of these interneurons improved neurogenesis and alleviated the schizophrenia-related behaviors. These results suggest a pivotal role of PV-positive interneuron-mediated adult neurogenesis in exercise. (3) However, schizophreniarelated behavioral phenotypes and adult neurogenesis in the DG could still be reversed by exercise after specifically knocking out the schizophrenia-related gene ErbB4 in PV interneurons, as a means to reduce their GABA release. These results suggest that activation of PV interneurons in the DG is sufficient for treadmill running to reverse schizophrenia-like phenotypes.

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Section: Discussionmentioning

confidence: 99%

Parvalbumin Interneuron Activation-Dependent Adult Hippocampal Neurogenesis Is Required for Treadmill Running to Reverse Schizophrenia-Like Phenotypes

Song

2020

Front. Cell Dev. Biol.

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“…There is evidence that poor cognition contributes to poorer physical health outcomes (e.g. higher BMI), reduced sleep quality and lower levels of physical activity (Kurebayashi & Otaki, 2017; Rashid et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Cognitive remediation for inpatients with psychosis: a systematic review and meta-analysis

et al. 2020

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Cognitive difficulties are common in people with psychosis and associated with considerable disability. Cognitive remediation (CR) can reduce the burden of cognitive difficulties and improve functioning. While mental health care has predominantly shifted to the community, people with greater illness severity and complexity, and those with poor response to treatment and concomitant greater cognitive difficulties, continue to receive inpatient care. The aim of this study is to review and evaluate the acceptability and efficacy of CR for inpatients with psychosis. A systematic search was used to identify randomized controlled trials of CR for inpatients with psychosis. Demographic and clinical information was extracted by independent raters together with therapy outcomes. Study quality was assessed using the Cochrane Collaboration Risk of Bias Assessment tool. Standardized mean change for cognitive and functional outcomes was calculated using Hedges's g and used to infer therapy effects with meta-analysis. Twenty studies were identified considering 1509 participants. Results from random-effect models suggested that CR was effective in improving processing speed (g = 0.48), memory (g = 0.48) and working memory (g = 0.56). While there was an indication of improvements in the levels of vocational, social and global functioning, these were less reliable. On average, 7% of participants dropped-out of treatment. Studies methodological quality was moderate. CR is an acceptable intervention for inpatients with psychosis and can lead to significant cognitive improvements. Evidence for improvement in functioning requires more robust and converging evidence. Future research should extend the evaluation of inpatient CR to subsequent post-discharge community functioning and further need for care.

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“…Recently, the association between physical activity and neurocognitive function has attracted attention, especially the relationship between lower physical activity and slower reaction times that is often reported . A recent longitudinal study reported that patients with schizophrenia who increased daily activity for 6 months had significant improvements in reaction times at follow‐up . Furthermore, an interventional study has suggested that aerobic exercise improves speed of processing .…”

Section: Discussionmentioning

confidence: 99%

Neurocognitive differences between inpatients and outpatients with symptomatically nonremitted schizophrenia: A cross-sectional study

Kurebayashi

Otaki

2018

Perspect Psychiatr Care

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Association between altered physical activity and neurocognitive function among people with schizophrenia: A minimum 6-months' follow-up study

Cited by 10 publications

References 26 publications

Parvalbumin Interneuron Activation-Dependent Adult Hippocampal Neurogenesis Is Required for Treadmill Running to Reverse Schizophrenia-Like Phenotypes

Parvalbumin Interneuron Activation-Dependent Adult Hippocampal Neurogenesis Is Required for Treadmill Running to Reverse Schizophrenia-Like Phenotypes

Cognitive remediation for inpatients with psychosis: a systematic review and meta-analysis

Neurocognitive differences between inpatients and outpatients with symptomatically nonremitted schizophrenia: A cross-sectional study

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