Association between alopecia areata and thyroid dysfunction

Naik, Piyu Parth; Farrukh, Syed Nadir

doi:10.1080/00325481.2021.1974689

Cited by 13 publications

(10 citation statements)

References 37 publications

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“…Pareado por edad, se observó una mayor frecuencia de comorbilidades cardiovasculares y endocrinológicas en pacientes mayores a 45 años, como se esperaría encontrar por la frecuencia de estas en la población general, sin embargo no existen reportes nacionales o internacionales que corroboren este hallazgo en otra población. Adicionalmente, se reporta una correlación entre la presencia de comorbilidades y el grado de severidad de las alopecias, esto vinculado a un proceso de inflamación sistémica y riesgo cardiovascular 26 .…”

Section: Discussionunclassified

Comorbilidades asociadas a alopecia <i>areata</i>, un estudio retrospectivo en un centro dermatológico de Bogotá

Cáceres-Salamanca,

Muñoz-Angulo,

Muñoz-Ordóñez

et al. 2023

MCUT

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La alopecia areata (AA) es una enfermedad crónica, con una presentación clínica diversa que se ha asociado con múltiples enfermedades a lo largo de los años. Se han publicado diferentes estudios sobre sus manifestaciones y comorbilidades, aunque los estudios en población latina son escasos. Objetivo: Identificar la presentación clínica más frecuente y enfermedades asociadas de la AA en población latinoamericana. Método: Se realizó un estudio transversal incluyendo pacientes diagnosticados con AA. Los datos se recolectaron de enero de 2018 a mayo de 2022 en un centro dermatológico en Bogotá, Colombia. Se realizó un análisis descriptivo con frecuencias relativas y absolutas. Resultados: Se analizaron un total de 257 pacientes con AA. La localización más frecuente de la lesión fue en piel cabelluda en el 86.1% (n = 237) de nuestra muestra, seguida de la cara con solo el 12% (n = 33). La afectación ungueal estuvo presente en un paciente. La mayoría de los pacientes presentaba más de una lesión (53%) y solo el 3.50% presentaba alopecia universal. Las comorbilidades más frecuentes reportadas fueron las enfermedades cardiovasculares y endocrinas, seguidas de las enfermedades atópicas, dermatológicas y gastrointestinales. La migraña y las enfermedades endocrinas fueron 8 y 3 veces más frecuentes en mujeres, respectivamente. Conclusión: La AA puede manifestarse en una variedad de presentaciones y está asociada con múltiples comorbilidades. El médico debe preguntar rigurosamente por cualquier comorbilidad y realizar una revisión por sistemas minuciosa para lograr un abordaje integral de la enfermedad.

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Section: Discussionunclassified

Comorbilidades asociadas a alopecia <i>areata</i>, un estudio retrospectivo en un centro dermatológico de Bogotá

Cáceres-Salamanca,

Muñoz-Angulo,

Muñoz-Ordóñez

et al. 2023

MCUT

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“…The cause of AA is not fully understood, but it is believed to involve genetic susceptibility, autoimmune processes, and potential stress as contributing factors [ 56 ]. AA patients have a higher prevalence of autoimmune conditions, including Hashimoto's thyroiditis [ 57 ]. Studies have shown that autoimmune thyroid diseases are more common in people with AA, and they are more likely to have thyroid dysfunction, such as subclinical hyperthyroidism and hypothyroidism [ 58 ].…”

Section: Reviewmentioning

confidence: 99%

Impact of Thyroid Dysfunction on Hair Disorders

Hussein,

Atia,

Bin Dayel

2023

Cureus

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Hair loss is a problem for everyone, regardless of their age or sex. The three most prevalent types of hair loss, telogen effluvium, alopecia areata, and androgenetic alopecia, have been associated with a variety of risk factors. Strong evidence links thyroid hormones (THs) to hair loss. THs control the growth, differentiation, metabolism, and thermogenesis of body cells. The skin is a significant target organ for THs; however, the cellular and molecular causes of thyroid dysfunction-related skin diseases remain unknown. Hyperthyroidism, hypothyroidism, and drug-induced hypothyroidism can induce widespread hair shedding. Little information is available regarding the incidence and effects of thyroid dysfunction on hair problems. This study aimed to review the impact and prevalence of thyroid disorders on hair loss. The conclusions drawn from this study highlight the underestimated prevalence and impact of thyroid disorders on hair loss. The review of scientific articles, including original research, review articles, and a case report, provides a comprehensive understanding of the topic. This research adds to the existing literature by enhancing our understanding of the relationship between thyroid dysfunction and hair disorders. It contributes to the body of evidence by reviewing relevant studies and summarizing the impact of thyroid disorders on hair loss. The study also highlights the gaps in knowledge and the need for more research in this area to improve the diagnosis and management of hair disorders associated with thyroid dysfunction.

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“…In a prior study, among the 23% of participants who experienced AA, this disease was attributable to psychological stress in almost twice as many patients than in those without stress [6]. Additionally, patients with certain autoimmune diseases, such as allergies, psoriasis, thyroid disease, and vitiligo, are more likely to develop AA; however, the exact cause for this increased susceptibility remains unknown [7,8]. Normal immune cells do not harm the body nor the hair follicles (HFs).…”

Section: Introductionmentioning

confidence: 99%

“…Normal immune cells do not harm the body nor the hair follicles (HFs). However, it has been hypothesized that when the immune system changes due to various reasons, immune cells can cause the inflammation of the HFs, resulting in the development of AA [7,8]. As AA disrupts hair growth patterns via HF inflammation, it is therefore necessary to differentiate between the changes that arise as part of the normal hair growth cycle, and changes that occur due to the development of AA [9].…”

Section: Introductionmentioning

confidence: 99%

Psychological Stress-Induced Pathogenesis of Alopecia Areata: Autoimmune and Apoptotic Pathways

Ahn

Lee

Hahm

2023

IJMS

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Alopecia areata (AA) is an autoimmune dermatological disease with multifactorial etiology and is characterized by reversible hair loss in patches. AA may be closely related to emotional stress and influenced by psychological factors as part of its pathophysiology; however, its etiology remains predominantly unknown. This review aimed to elucidate the association between AA occurrence and the neuropeptide substance P (SP) and corticotropin-releasing hormone (CRH), which are secreted during emotional stress, and have been understood to initiate and advance the etiopathogenesis of AA. Therefore, this review aimed to explain how SP and CRH initiate and contribute to the etiopathogenesis of AA. To assess the etiopathogenesis of AA, we conducted a literature search on PubMed and ClinicalTrials.gov. Overall, several authors described interactions between the hair follicles (HFs) and the stress-associated signaling substances, including SP and CRH, in the etiology of AA; this was attributed to the understanding in that AA can occur without the loss of HFs, similar to that observed in hereditary hair loss with age. Most studies demonstrated that the collapse of “immune privilege” plays a crucial role in the development and exacerbation of the AA; nonetheless, a few studies indicated that substances unrelated to autoimmunity may also cause apoptosis in keratocytes, leading to the development of AA. We investigated both the autoimmune and apoptotic pathways within the etiology of AA and assessed the potential interactions between the key substances of both pathways to evaluate potential therapeutic targets for the treatment of AA. Clinical trials of marketed/unreviewed intervention drugs for AA were also reviewed to determine their corresponding target pathways.

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Association between alopecia areata and thyroid dysfunction

Cited by 13 publications

References 37 publications

Comorbilidades asociadas a alopecia <i>areata</i>, un estudio retrospectivo en un centro dermatológico de Bogotá

Comorbilidades asociadas a alopecia <i>areata</i>, un estudio retrospectivo en un centro dermatológico de Bogotá

Impact of Thyroid Dysfunction on Hair Disorders

Psychological Stress-Induced Pathogenesis of Alopecia Areata: Autoimmune and Apoptotic Pathways

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