Association between alcohol consumption and the risk of incident type 2 diabetes: a systematic review and dose-response meta-analysis

Li, Xiaohua; Yu, Feifei; Zhou, Yuhao; He, Jia

doi:10.3945/ajcn.115.114389

Cited by 163 publications

(137 citation statements)

References 61 publications

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“…There seems to be a beneficial effect of alcohol use on diabetes mellitus type 2 incidence 188, as evidenced in meta‐analyses and in systematic reviews 189, 190, 191, 192, 193. However, this seemingly unambiguous picture must be qualified by different results by gender and ethnicity.…”

Section: Resultsmentioning

confidence: 99%

The relationship between different dimensions of alcohol use and the burden of disease—an update

et al. 2017

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Background and aimsAlcohol use is a major contributor to injuries, mortality and the burden of disease. This review updates knowledge on risk relations between dimensions of alcohol use and health outcomes to be used in global and national Comparative Risk Assessments (CRAs).MethodsSystematic review of reviews and meta‐analyses on alcohol consumption and health outcomes attributable to alcohol use.For dimensions of exposure: volume of alcohol use, blood alcohol concentration and patterns of drinking, in particular heavy drinking occasions were studied. For liver cirrhosis, quality of alcohol was additionally considered. For all outcomes (mortality and/or morbidity): cause of death and disease/injury categories based on International Classification of Diseases (ICD) codes used in global CRAs; harm to others.ResultsIn total, 255 reviews and meta‐analyses were identified. Alcohol use was found to be linked causally to many disease and injury categories, with more than 40 ICD‐10 three‐digit categories being fully attributable to alcohol. Most partially attributable disease categories showed monotonic relationships with volume of alcohol use: the more alcohol consumed, the higher the risk of disease or death. Exceptions were ischaemic diseases and diabetes, with curvilinear relationships, and with beneficial effects of light to moderate drinking in people without heavy irregular drinking occasions. Biological pathways suggest an impact of heavy drinking occasions on additional diseases; however, the lack of medical epidemiological studies measuring this dimension of alcohol use precluded an in‐depth analysis. For injuries, except suicide, blood alcohol concentration was the most important dimension of alcohol use. Alcohol use caused marked harm to others, which has not yet been researched sufficiently.ConclusionsResearch since 2010 confirms the importance of alcohol use as a risk factor for disease and injuries; for some health outcomes, more than one dimension of use needs to be considered. Epidemiological studies should include measurement of heavy drinking occasions in line with biological knowledge.

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Section: Resultsmentioning

confidence: 99%

The relationship between different dimensions of alcohol use and the burden of disease—an update

et al. 2017

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“…Although light to moderate alcohol consumption was associated with a lower risk of diabetes mellitus [7,8], the pathological mechanisms underlying alcohol consumption in diabetes mellitus are complex. Some studies have suggested that moderate alcohol consumption is associated with improved insulin sensitivity [9,10], whereas a meta-analysis of intervention studies revealed no relationship between moderate alcohol consumption and insulin sensitivity [21].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, it has been shown that high alcohol consumption increases the risk of both T2DM and pre-diabetes [5], and in some cases is an independent risk factor for pre-diabetes [6]. In contrast, other studies have shown that light and moderate alcohol consumption protects against T2DM [7,8]. …”

Section: Introductionmentioning

confidence: 99%

The Association between Alcohol Consumption and β-Cell Function and Insulin Sensitivity in Korean Population

Yoo

Kim

Jang

et al. 2016

IJERPH

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Abstract:This cross-sectional study was performed to examine the association between alcohol consumption and insulin secretion and sensitivity using the Korean Genome and Epidemiology Study. Alcohol consumption levels were categorized into four groups: (i) abstainers, (ii) low (<5 g/day), (iii) intermediate (<30 g/day), and (iv) high (≥30 g/day) alcohol consumption. β-cell function and insulin sensitivity were estimated using the insulinogenic index (IGI 60 ), and Matsuda insulin sensitivity index (ISI), respectively. IGI 60 and ISI were dichotomized into high and low groups using median cut-off values and four groups were defined (G-I: high IGI 60 /high ISI; G-II: high IGI 60 /low ISI; G-III: low IGI 60 /high ISI; and G-IV: low IGI 60 /low ISI). Men consumed 26.5 g alcohol per day on average, whereas women only consumed 5.7 g/day, so women were excluded from subsequent analyses due to their low drinking levels. Alcohol consumption was positively associated with high-density lipoprotein (HDL) cholesterol, aspartate aminotransferase (AST), and triglycerides (TG) in men, but was negatively associated with IGI 60 (p < 0.05). TG levels were only increased in individuals with decreased insulin sensitivity (G-II) or decreased β-cell function (G-III) with high alcohol consumption. In addition, alcohol consumption increased HDL cholesterol in the four groups (p < 0.001). In subjects with decreased insulin sensitivity (G-II), intermediate and high alcohol consumption increased the risk of high cholesterol and TG. In individuals with decreased β-cell function (G-III), alcohol consumption increased the risk of high TG and high AST levels. High alcohol consumption was significantly associated with reduced insulin secretion. In addition, alcohol consumption was related to some metabolic risk factors depending on insulin secretion or sensitivity.

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“…Especialmente em fumantes e mulheres, o consumo de pequenas a moderadas quantidades de álcool está associado com um risco menor de DM2, provavelmente por aumentar a sensibilidade insulínica e reduzir a resistência a esse hormônio durante o jejum [27]. No entanto, o consumo exagerado de álcool potencializa o desenvolvimento de DM por disfunção das células beta-pancreáticas e por ser um fator de risco para cirrose hepática, que aumenta o risco para DM2 [28].…”

Section: /6unclassified

Prevalência de hiperglicemia em idosos: um estudo de base populacional

Espanhol

Oliveira²,

Silvano

et al. 2016

Sci Med

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Este artigo está licenciado sob forma de uma licença Creative Commons Atribuição 4.0 Internacional, que permite uso irrestrito, distribuição e reprodução em qualquer meio, desde que a publicação original seja corretamente citada. ABSTRACT Aims:To evaluate the prevalence of hyperglycemia and associated factors in the elderly population of a municipality in southern Brazil. Methods: Cross-sectional population-based study, carried out with the elderly (≥60 years) living in the city of Tubarão, state of Santa Catarina, Brazil, from September 2010 to May 2011. Participants were selected by simple random sampling. The elderly were registered by the Community Health Agents of the Family's Health Strategy Program. Sociodemographic data (age, gender, skin color, marital status, employment status and education), behavioral data (physical activity, alcohol use and smoking) and clinical data (obesity, drug use and family history of diabetes) were recorded. After answering these questions the participants were scheduled to attend the clinic for blood collection and anthropometric measurements. The prevalence of hyperglycemia was assessed from fasting blood glucose tests, and individuals with values ≥126 mg/dL or use of hypoglycemic drugs were considered hyperglycemic. To assess the association between the variables of interest, the chi-square test was applied. The pre-determined confidence interval was of 95% and the error α of 5%. Results: Eight hundred thirty-three elderly patients were included, and 220 were considered hyperglycemic according to the methodology criteria (prevalence of 26.4%). Of the patients included in the hyperglycemia group, 190 were using oral hypoglycemic drugs, and of these, 112 had also fasting glucose ≥126 mg/dL, while in 78 fasting glucose was <126 mg/dL. Also in the hyperglycemia group, 30 patients had fasting glucose ≥126 mg/dL and were not on hypoglycemic treatment. Having parents diagnosed with diabetes and being obese were associated with the presence of hyperglycemia. Conclusions:This study suggests that a large portion of the elderly population has fasting hyperglycemia, requiring a wider evaluation for diabetes mellitus.

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Association between alcohol consumption and the risk of incident type 2 diabetes: a systematic review and dose-response meta-analysis

Cited by 163 publications

References 61 publications

The relationship between different dimensions of alcohol use and the burden of disease—an update

The relationship between different dimensions of alcohol use and the burden of disease—an update

The Association between Alcohol Consumption and β-Cell Function and Insulin Sensitivity in Korean Population

Prevalência de hiperglicemia em idosos: um estudo de base populacional

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