Association between air pollution and development of atrial fibrillation: A meta-analysis of observational studies

Kong

Pacing Clinical Electrophis

et al. 2018

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Effects of the short‐term exposure to ambient air pollution on atrial fibrillation

Kong

Pacing Clinical Electrophis

et al. 2018

“…PM2.5 exposure together with cigarette smoking has been demonstrated to have an even greater impact on cardiovascular disease-associated mortality (23). A meta-analysis study indicated that ambient PM2.5 exposure was associated with a high risk of atrial fibrillation (24). However, it has been reported that lung cancer and cardiovascular diseases respond differently to PM2.5 exposure (25).…”

Section: Pm25 Has An Adverse Impact On Cardiovascular Respiratory Amentioning

confidence: 99%

Function of PM2.5 in the pathogenesis of lung cancer and chronic airway inflammatory diseases (Review)

2018

Previous research has identified that air pollution is associated with various respiratory diseases, but few studies have investigated the function served by particulate matter 2.5 (PM2.5) in these diseases. PM2.5 is known to cause epigenetic and microenvironmental alterations in lung cancer, including tumor-associated signaling pathway activation mediated by microRNA dysregulation, DNA methylation, and increased levels of cytokines and inflammatory cells. Autophagy and apoptosis of tumor cells may also be detected in lung cancer associated with PM2.5 exposure. A number of mechanisms are involved in triggering and aggravating asthma and COPD, including PM2.5-induced cytokine release and oxidative stress. The present review is an overview of the underlying molecular mechanisms of PM2.5-induced pathogenesis in lung cancer and chronic airway inflammatory diseases.

Acta Medica Marisiensis

“…Epidemiological evidence, mostly derived from studies in patients with implanted cardioverter defibrillators, associates air pollution with an elevated risk of AF [63], mainly via pollution-induced inflammation [64]. In addition, increased levels of pollutants, particularly carbon monoxide and carbon black, have been associated with HRV reduction [65].…”

Section: Air Pollutionmentioning

confidence: 99%

Atrial Fibrillation – An Orchestra of Classic and Modern Risk Factors

Balan

Scridon

2019

Over the past years, prevention and control of risk factors has begun to play an important role in the management of patients prone to develop atrial fibrillation (AF). A considerable number of risk factors that contribute to the creation of a predisposing substrate for AF has been identified over the years. Although certain AF risk factors such as age, gender, genetic predisposition, or race are unmodifiable, controlling modifiable risk factors may represent an invaluable tool in the management of AF patients. In the recent decades, numerous studies have evaluated the mechanisms linking different risk factors to AF, but the exact degree of atrial remodeling induced by each factor remains unknown. Elucidating these mechanisms is essential for initiating personalized therapies in patients prone to develop AF. The present review aims to provide an overview of the most relevant modifiable risk factors involved in AF occurrence, with a focus on the mechanisms by which these factors lead to AF initiation and perpetuation.