Association Between Air Pollution and Coronary Artery Calcification Within Six Metropolitan Areas in the USA (the Multi-Ethnic Study of Atherosclerosis and Air Pollution): A Longitudinal Cohort Study

Kaufman, Joel D.; Adar, Sara D.; Barr, R. Graham

doi:10.1016/j.jvs.2016.09.013

Cited by 83 publications

(122 citation statements)

References 21 publications

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“…In contrast to MESA 16 , we did not find evidence of strong positive associations of PM 2.5 or distance to a major roadway with CAC progression. Of note, there was a relatively short time between the first and second MDCT scans (average 6.1 years) in our study.…”

Section: Discussioncontrasting

confidence: 99%

“…10 However, more recently, MESA has found PM 2.5 and nitrogen oxides, a marker of traffic-related air pollution, were positively associated with CAC progression. 16 …”

Section: Discussionmentioning

confidence: 99%

“…7,8 Epidemiological studies have also provided evidence of positive associations between ambient particles and traffic with atherosclerosis markers. 9–16 …”

Section: Introductionmentioning

confidence: 99%

“…9,10,16 Given this background, we aimed to assess whether there were associations of these exposures with CAC among participants from the Framingham Heart Study living in the Northeastern U.S., a region with relatively low PM 2.5 levels. CAC provides a quantitative estimate of total coronary atheroma (both calcified and non-calcified plaque).…”

Section: Introductionmentioning

confidence: 99%

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Residential Proximity to Major Roads, Exposure to Fine Particulate Matter, and Coronary Artery Calcium

Dorans

Wilker

et al. 2016

ATVB

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Objective Long-term exposure to traffic and particulate matter air pollution is associated with a higher risk of cardiovascular disease, potentially via atherosclerosis promotion. Prior research on associations of traffic and particulate matter with coronary artery calcium Agatston score (CAC), an atherosclerosis correlate, has yielded inconsistent findings. Given this background, we assessed whether residential proximity to major roadway or fine particulate matter (PM2.5) were associated with CAC in a Northeastern U.S. study. Approach and Results We measured CAC up to two times from 2002–2005 and 2008–2011 among Framingham Offspring or Third Generation Cohort participants. We assessed associations of residential distance to major roadway and residential PM2.5 (2003 average; spatiotemporal model) with detectable CAC, using generalized estimating equation regression. We used linear mixed effects models to assess associations with loge(CAC). We also assessed associations with CAC progression. Models were adjusted for demographic variables, socioeconomic position markers and time. Among 3,399 participants, 51% had CAC measured twice. CAC was detectable in 47% of observations. At first scan, mean age was 52.2 years (standard deviation 11.7); 51% male. There were no consistent associations with detectable CAC, continuous CAC or CAC progression. We observed heterogeneous associations of distance to major roadway with odds of detectable CAC by hypertensive status; interpretation of these findings is questionable. Conclusions Our findings add to prior work and support evidence against strong associations of traffic or PM2.5 with the presence, extent or progression of CAC in a region with relatively low levels of and little variation in PM2.5.

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Section: Discussioncontrasting

confidence: 99%

“…10 However, more recently, MESA has found PM 2.5 and nitrogen oxides, a marker of traffic-related air pollution, were positively associated with CAC progression. 16 …”

Section: Discussionmentioning

confidence: 99%

“…7,8 Epidemiological studies have also provided evidence of positive associations between ambient particles and traffic with atherosclerosis markers. 9–16 …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Residential Proximity to Major Roads, Exposure to Fine Particulate Matter, and Coronary Artery Calcium

Dorans

Wilker

et al. 2016

ATVB

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“…MESA and ancillary studies, MESA Lung and Air, are described in depth elsewhere and served as the sampling frame for this study. 10,16 Informed consent was obtained for all participants and the study was approved by the Institutional Review Board at collaborating centers.…”

Section: Methodsmentioning

confidence: 99%

Air pollution and subclinical interstitial lung disease: the Multi-Ethnic Study of Atherosclerosis (MESA) air–lung study

et al. 2017

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We sought to determine whether ambient air pollution is associated with interstitial lung abnormalities (ILA) and high attenuation areas (HAA), which are qualitative and quantitative measurements of subclinical ILD on computed tomography. We performed analyses of 6813 community-based dwellers enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA), a U.S.-based prospective cohort study. We used cohort-specific spatiotemporal models to estimate predictions of ambient pollution (PM2.5, NOx, NO2 and O3) at each home. Participants underwent serial assessment of HAA by cardiac CT-scan and a subset of participants was assessed for ILA using full lung CT scan at 10 year follow-up. We used multivariable logistic regression and linear mixed models adjusted for age, sex, ethnicity, education, tobacco use, scanner technology and study site. The odds of ILA increased 1.62-fold per 40ppb increment in NOx (95%CI 0.97 to 2.71, p-value 0.06), and were strongest in non-smokers (2.60-fold increase per 40ppb increment in NOx, 95% CI 1.20 to 5.61, p-value 0.02). HAA increased by 0.54% per year per 5μg/m3 increment in PM2.5 (95%CI 0.02% to 1.10%, p-value 0.04) and by 0.55% per year per 40ppb increment in NOx (95%CI 0.08% to 1.00%, p-value 0.02). Ambient air pollutants were associated with measurements of subclinical ILD.

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An Education Imperative: Integrating Climate Change Into the Emergency Medicine Curriculum

Moretti

2020

AEM Education and Training

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Association Between Air Pollution and Coronary Artery Calcification Within Six Metropolitan Areas in the USA (the Multi-Ethnic Study of Atherosclerosis and Air Pollution): A Longitudinal Cohort Study

Cited by 83 publications

References 21 publications

Residential Proximity to Major Roads, Exposure to Fine Particulate Matter, and Coronary Artery Calcium

Residential Proximity to Major Roads, Exposure to Fine Particulate Matter, and Coronary Artery Calcium

Air pollution and subclinical interstitial lung disease: the Multi-Ethnic Study of Atherosclerosis (MESA) air–lung study

An Education Imperative: Integrating Climate Change Into the Emergency Medicine Curriculum

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