Association Between Air Pollutants and Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Time Stratified Case‐Crossover Design With a Distributed Lag Nonlinear Model

Liu, Yanchen; Han, Xiaoli; Cui, Xudong; Zhao, Xiangkai; Zhao, Xin; Zheng, Hongmiao; Zhang, Benzhong; Ren, Xiaowei

doi:10.1029/2021gh000529

Cited by 9 publications

(4 citation statements)

References 32 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This suggests that the immediate effects of these air pollutants were stronger than the delayed effects. Furthermore, low levels of SO 2 and CO exhibited a protective effect on AECOPD, which gradually increased over time until a lag of 27 days (39). The nonlinear effects of different air pollutants on AECOPD varied based on factors such as gender, age, and seasons (40).…”

Section: Figurementioning

confidence: 98%

Environmental pollutants increase the risks of acute exacerbation in patients with chronic airway disease

Chou,

Chen,

Peng

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

ObjectiveRespiratory infections are a common cause of acute exacerbations in patients with chronic airway disease, however, environmental factors such as air pollution can also contribute to these exacerbations. The study aimed to determine the correlation between pollutant levels and exacerbation risks in areas exposed to environmental pollution sources.MethodsFrom 2015 to 2016, a total of 788 patients with chronic airway diseases were enrolled in a study. Their medical records, including hospital visits due to acute exacerbations of varying severity were analyzed. Additionally, data on daily pollutant levels from the Air Quality Monitoring Network from 2014 to 2016 was also collected and analyzed.ResultsPatients with chronic airway disease and poor lung function (FEV1 < 50% or obstructive ventilatory defect) have a higher risk of severe acute exacerbations and are more likely to experience more than two severe acute exacerbations within a year. The study found that in areas exposed to environmental pollution sources, there is a significant correlation between NO2, O3, and humidity with the main causes of severe acute exacerbation. When the levels of NO2 were higher than 16.65 ppb, O3 higher than 35.65 ppb, or humidity higher than 76.95%, the risk of severe acute exacerbation in patients with chronic airway disease increased.ConclusionAcute exacerbations of chronic airway disease can be triggered by both the underlying disease state and the presence of air pollution. Computer simulations and early warning systems should be developed to predict acute exacerbations of chronic airway disease based on dynamic changes in air pollution.

show abstract

Section: Figurementioning

confidence: 98%

Environmental pollutants increase the risks of acute exacerbation in patients with chronic airway disease

Chou,

Chen,

Peng

et al. 2023

Front. Public Health

View full text Add to dashboard Cite

show abstract

“…The worldwide COVID-19 pandemic burden had reached approximately 63 billion cases as of November 2022, with massive breakouts in different countries [ 1 ]. Chronic obstructed pulmonary disease (COPD) affected over 251 million people worldwide, and 3.17 million deaths were reported each year [ 2 , 3 ]. According to the World Health Organization (WHO) report 2022, based on electronic data collected from 215 countries, approximately 40 million people were treated for multidrug and rifampicin-resistant tuberculosis (MDR/RR-TB) worldwide, with 649,000 adults and 17,700 children receiving treatment [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of covid-19 among patients with chronic obstructive pulmonary disease and tuberculosis

et al. 2023

View full text Add to dashboard Cite

Background The exhaustive information about non-communicable diseases associated with COVID-19 and severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) are getting easier to find in the literature. However, there is a lack of knowledge regarding tuberculosis (TB) and chronic obstructed pulmonary disease (COPD), with numerous infections in COVID-19 patients. Objectives Priority is placed on determining the patient’s prognosis based on the presence or absence of TB and COPD. Additionally, a comparison is made between the risk of death and the likelihood of recovery in terms of time in COVID-19 patients who have either COPD or TB. Methodology At the DHQ Hospital in Muzaffargarh, Punjab, Pakistan, 498 COVID-19 patients with TB and COPD were studied retrospectively. The duration of study started in February 2022 and concluded in August 2022. The Kaplan–Meier curves described time-to-death and time-to-recovery stratified by TB and COPD status. The Wilcoxon test compared the survival rates of people with TB and COPD in two matched paired groups and their status differences with their standard of living. Results The risk of death in COVID-19 patients with TB was 1.476 times higher than in those without (95% CI: 0.949–2.295). The recovery risk in COVID-19 patients with TB was 0.677 times lower than in those without (95% CI: 0.436–1.054). Similarly, patients with TB had a significantly shorter time to death ( p =.001) and longer time to recovery ( p =.001). Conclusions According to the findings, the most significant contributor to an increased risk of morbidity and mortality in TB and COPD patients was the COVID-19. KEY MESSAGES SARS-Cov-19 is a new challenge for the universe in terms of prevention and treatment for people with tuberculosis and chronic obstructive pulmonary disease, among other diseases. Propensity score matching to control for potential biases. Compared to hospitalized patients with and without (TB and COPD) had an equivalently higher mortality rate.

show abstract

“…The 2020 Report on the State of Ecology and Environment in China issued by Ministry of Ecology and Environment showed that 43.3% of 337 cities exceeded the ambient air quality standard (2020). As people pay more attention to environmental pollution, some studies on the association between COPD and air pollution have been conducted in China (Feng et al 2019 ; Jin et al 2022 ; Lin et al 2020 ; Liu et al 2022 ; Qiu et al 2018 ; Zhang et al 2020 ; Zhang et al 2018 ). However, these studies found different components of air pollutants affecting COPD admissions, with inconsistent conclusions and lack of research analysis in recent years.…”

Section: Introductionmentioning

confidence: 99%

Associations between air pollutants and hospital admissions for chronic obstructive pulmonary disease in Jinan: potential benefits from air quality improvements

Cheng

Han

Fang

et al. 2023

Environ Sci Pollut Res

View full text Add to dashboard Cite

Evidence between air pollution and chronic obstructive pulmonary disease (COPD) is inconsistent and limited in China. In this study, we aim to examine the associations between air pollutants and hospital admissions for COPD, hoping to provide practical advice for prevention and control of COPD. Hospital admissions for COPD were collected from a Grade-A tertiary hospital in Jinan from 2014 to 2020. A generalized additive model (GAM) was used to examine the associations between air pollutants and hospital admissions for COPD. Stratified analysis was also conducted for gender, age (20–74 and ≥75 years), and season (warm and cold). The avoidable number of COPD hospital admissions was calculated when air pollutants were controlled under national and WHO standards. Over the study period, a total of 4,012 hospital admissions for COPD were recorded. The daily hospital admissions of COPD increased by 2.36% (95% CI : 0.13–4.65%) and 2.39% (95% CI : 0.19–4.65%) for per 10 μg/m 3 increase of NO 2 and SO 2 concentrations at lag2, respectively. There was no statistically significant difference in health effects caused by increased concentrations of PM 2.5 , PM 10 , CO, and O 3 . The health effects of increased SO 2 concentration were stronger in women, the ≥75 years old people and the cold season. About 2 (95% CI : 0–3), 64 (95% CI : 4–132) and 86 (95% CI : 6–177) COPD admissions would be avoided when the SO 2 concentration was controlled below the NAAQS-II (150 μg/m 3 ), NAAQS-I (50 μg/m 3 ), and WHO’s AQG2021 standard (40 μg/m 3 ), respectively. These findings suggest that short-term exposure to NO 2 and SO 2 was associated with increased risks of daily COPD admissions, especially for females and the elderly. The control of SO 2 and NO 2 under the national and WHO standards could avoid more COPD admissions and obtain greater health benefits. Supplementary Information The online version contains supplementary material available at 10.1007/s11356-023-25567-8.

show abstract

Association Between Air Pollutants and Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Time Stratified Case‐Crossover Design With a Distributed Lag Nonlinear Model

Cited by 9 publications

References 32 publications

Environmental pollutants increase the risks of acute exacerbation in patients with chronic airway disease

Environmental pollutants increase the risks of acute exacerbation in patients with chronic airway disease

Prevalence of covid-19 among patients with chronic obstructive pulmonary disease and tuberculosis

Associations between air pollutants and hospital admissions for chronic obstructive pulmonary disease in Jinan: potential benefits from air quality improvements

Contact Info

Product

Resources

About