Association between AgNORs and Immunohistochemical Expression of ER, PR, HER2/neu, and p53 in Breast Carcinoma

Ahmed, Hussain Gadelkarim; Al-Adhraei, Mohammed Ali; Ashankyty, Ibraheem

doi:10.4061/2011/237217

Cited by 15 publications

(13 citation statements)

References 27 publications

(27 reference statements)

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“…It is interesting to hypothesize, that the numbers, the shape, and the distribution of AgNORs within the nucleus might be potential use in predicting behavior in breast carcinomas. The AgNORs staining in the present study was found to be a very useful prognostic marker of cell proliferation and it has correlation with ER and PR receptors, it has been shown that there are significantly inversely associated between the AgNORs counts with PR and PR expression, our result agreed with Ahmed et al (2011). This study agrees with Ahmed et al (2013) shown in his study that the mean of AgNORs counts were high in hormonal receptors negative (ER+ve = 2.45 vs. ER-ve= 2.71 and PR+ve= 2.36 vs. PR-ve= 2.71) and p53 positive cases.…”

Section: The Relationship Between Agnor and Pr Er Her2supporting

confidence: 89%

Predictability of the Expression of ER, PR Receptors, HER2 and AgNORs in Breast Carcinoma among Iraqi Women in Thi - Qar Province: Immunohistochemical study

2019

University of Thi-Qar Journal of Science

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This study is descriptive exploratory in Thi-Qar providence for some breast cancer patients .The study aims of the study to assess the relationship between ER,PR,HER2 and the nuclear regulatory regions Argyrophilic nucleolar organizer region (AgNOR (in breast cancer. The present study addressed the identification the nuclear organization region in the breast cancer patients in Thi-Qar providence and the extent of their association with ER, PR and HER2 in the occurrence of breast cancer. Fifty tissue samples collected from Hussein Teaching Hospital in Thi Qar and some private laboratories in the province with the province of each case data included the most important factor is age, found that the highest percentage of injuries, age (55-46 years) increased by 38%. And mixed samples. Either partial removal of the tumor or whole breast. The results of the current study showed that there was a clear positive relationship between nuclear organization regions and breast cancer, as it was noted the presence of many of the nuclear regions of the dye-derived tissue sections of tumors while nuclear chromosomal regions did not appear in the sections derived from tumors with negative expression of estrogen receptor and progesterone hormone.

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Section: The Relationship Between Agnor and Pr Er Her2supporting

confidence: 89%

Predictability of the Expression of ER, PR Receptors, HER2 and AgNORs in Breast Carcinoma among Iraqi Women in Thi - Qar Province: Immunohistochemical study

2019

University of Thi-Qar Journal of Science

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“…Figure E shows the micrographs of tissue sections with their nucleolar proteins stained by silver ions (AgNORs). Specifically, tumor section treated with Ato‐ICG‐GNPs led to the production of least content of staining that would suggest an impaired proliferation . Additionally, we assessed the tissue damage caused by different treatments using hematoxylin and eosin (H&E) staining at day 7 (Figure F).…”

Section: Resultsmentioning

confidence: 99%

Overcoming Hypoxia by Multistage Nanoparticle Delivery System to Inhibit Mitochondrial Respiration for Photodynamic Therapy

Xia

Luo

et al. 2019

Adv Funct Materials

145

112

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Hypoxia, as characterized by the low local oxygen, confers on cancer cells resistance to oxygen-consuming photodynamic therapy (PDT). The limited success reached by current approaches harnessing reoxygenation to enhance PDT outcome promotes the reconsideration of the design of the therapeutic approach. In this study, a multistage delivery system capable of reversing hypoxia is demonstrated. Unlike previous strategies that only expect to affect the peripheral tumor tissue, the size-shrinkable system allows those deeply located hypoxia regions to be treated. Specifically, therapeutics, including atovaquone and indocyanine green derivatives that are respectively responsible for oxidative phosphorylation blockage and PDT, are encapsulated in a gelatin nanoparticle, whose structure would rupture to promote deep penetration when facing matrix metallopeptidase 2 enzyme overexpression in tumor tissue. The antihypoxic performance of the platform has been evaluated using a variety of analyses including flow-cytometry assay, immunofluorescence, and micro-positron-emission tomography imaging. Tumor regression in animal models confirms the feasibility and effectiveness of conquering the PDT-resistance through abrogating the oxygen consumption. It is hopeful that such a strategy could shed light on the development of next-generation PDT-adjuvant treatment.

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“…The utility of AgNORs count in breast cancer has been addressed by a number of studies. Beside it is utility as quantitative evidence for a distinction between benign and malignant lesions [22], some studies revealed its value as a prognostic factor in breast cancer [23]. The elevated number of AgNORs mean dots count is measured to be a diagnostic and prognostic factor due to its direct link to cell proliferation and ribosomal biogenesis [24].…”

Section: Discussionmentioning

confidence: 99%

A Correlation between Histochemical Patterns of Connective Tissue Fibers and AgNORs in Breast Lesions

Elasbali¹

2019

OJPathology

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Background: The precise histopathologic diagnosis of a breast lesion is the first step towards the most appropriate inclusive patient's management. The aim of this study was to evaluate the correlation between histochemical patterns of connective tissue fibers and NORs in breast lesions. Methodology: Patients with breast cancer (n = 25) were ascertained as the case group, and those with benign breast lesions were ascertained as a control group (n = 25). Histochemical evaluations of elastic fibers, reticular fibers and mean AgNORs count were performed for all study subjects. Results: Elastic fibers intensity was brought into being lessening in benign lesions and upturns in the direction of malignant lesions. The intensity of elastic fibers was found to intensify with rises of neoplastic changes in breast cancer and this was found to be statistically significant P < 0.001. Mean AgNORs counts displayed increased clusters among malignant cases equated to benign ones. Mean AgNORs count significantly increased with neoplastic proliferation P < 0.005. Conclusion: Demonstration of connective tissue fibers (particularly elastic fibers) can strength the diagnostic evidence for conventional histopathology diagnosis. Mean AgNORs count can merge as an important quantitative marker in breast cancer diagnosis.

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Association between AgNORs and Immunohistochemical Expression of ER, PR, HER2/neu, and p53 in Breast Carcinoma

Cited by 15 publications

References 27 publications

Predictability of the Expression of ER, PR Receptors, HER2 and AgNORs in Breast Carcinoma among Iraqi Women in Thi - Qar Province: Immunohistochemical study

Predictability of the Expression of ER, PR Receptors, HER2 and AgNORs in Breast Carcinoma among Iraqi Women in Thi - Qar Province: Immunohistochemical study

Overcoming Hypoxia by Multistage Nanoparticle Delivery System to Inhibit Mitochondrial Respiration for Photodynamic Therapy

A Correlation between Histochemical Patterns of Connective Tissue Fibers and AgNORs in Breast Lesions

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