Association between age at diagnosis of type 2 diabetes and cardiovascular morbidity and mortality risks: A nationwide population-based study

Seo, Da Hea; Kim, Mina; Suh, Young Ju; Cho, Yongin; Ahn, Seong Hee; Hong, Seongbin; Kim, So Hun

doi:10.1016/j.diabres.2024.111098

Diabetes Research and Clinical Practice

2024

DOI: 10.1016/j.diabres.2024.111098

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Association between age at diagnosis of type 2 diabetes and cardiovascular morbidity and mortality risks: A nationwide population-based study

Da Hea Seo,

Mina Kim,

Young Ju Suh

et al.

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Cited by 4 publications

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Social and Structural Determinants of Cardiovascular Complications of Diabetes

Mensah,

Valdez,

Gyawali

et al. 2024

Curr Diab Rep

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Social and Structural Determinants of Cardiovascular Complications of Diabetes

Mensah,

Valdez,

Gyawali

et al. 2024

Curr Diab Rep

View full text Add to dashboard Cite

Association of age at diagnosis of type 2 diabetes mellitus with the risks of the morbidity of cardiovascular disease, cancer and all-cause mortality: Evidence from a real-world study with a large population-based cohort study

Li,

Luo,

Bao

et al. 2024

Diabetes Research and Clinical Practice

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All‐cause and cause‐specific mortality risk and loss in life expectancy associated with incident type 2 diabetes onset age and duration

Zhang,

Song,

Wang

et al. 2024

J Intern Med

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BackgroundEvidence on type 2 diabetes onset age and duration on mortality risk has been limited by short follow‐up, inadequate control for confounding, missing repeated measurements, and inability to cover the full range of onset age, duration, and major causes of death. Moreover, scarce data dissect how type 2 diabetes onset age and duration shape life expectancy.MethodsWe evaluate prospectively these topics based on 270,075 eligible participants in the Nurses’ Health Studies and Health Professionals Follow‐up Study, leveraging repeated measurements throughout up to 40 years of follow‐up. Cox models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).ResultsIn fully adjusted analyses, incident early onset type 2 diabetes (diagnosed <40 years of age) was associated with significantly higher mortality from all‐causes (HR, 95% CI was 3.16, 2.64–3.79; vs. individuals without type 2 diabetes), cardiovascular disease (6.56, 4.27–10.1), respiratory disease (3.43, 1.38–8.51), neurodegenerative disease (5.13, 2.09–12.6), and kidney disease (8.55, 1.98–36.9). The relative risk elevations declined dramatically with each higher decade of age at diagnosis for deaths from most of these causes, though the absolute risk difference increased continuously. A substantially higher cumulative incidence of mortality and a greater loss in life expectancy were associated with younger age at type 2 diabetes diagnosis. Longer disease duration was associated with generally higher relative and absolute risk of mortality.ConclusionEarly onset of type 2 diabetes and longer disease duration are associated with substantially increased risk of all‐cause and cause‐specific mortality and greater loss in life expectancy.

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Association between age at diagnosis of type 2 diabetes and cardiovascular morbidity and mortality risks: A nationwide population-based study

Cited by 4 publications

References 22 publications

Social and Structural Determinants of Cardiovascular Complications of Diabetes

Social and Structural Determinants of Cardiovascular Complications of Diabetes

Association of age at diagnosis of type 2 diabetes mellitus with the risks of the morbidity of cardiovascular disease, cancer and all-cause mortality: Evidence from a real-world study with a large population-based cohort study

All‐cause and cause‐specific mortality risk and loss in life expectancy associated with incident type 2 diabetes onset age and duration

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