Association between age and overall survival of patients with hepatocellular carcinoma after hepatic resection

Tan, Juntao; Zhao, Chang; Peng, Ning-Fu; Yang, Yang; Zhong, Jian‐Hong; Yang, Tian; Zheng, Ming‐Hua; Wang, Yanyan; Gong, Weijuan; Xiang, Bang‐De; Li, Le‐Qun

doi:10.1002/jso.24434

Cited by 18 publications

(14 citation statements)

References 44 publications

(46 reference statements)

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“…Stratifying these patients by various cut-off ages between 30 and 70 years showed that age did not significantly affect their prognosis. 27 We obtained similar results when we applied cut-off ages of 30 and 50 years (data not shown).…”

Section: Discussionsupporting

confidence: 69%

Analysis of Clinicopathological Characteristics and Prognosis of Young Patients with Hepatocellular Carcinoma after Hepatectomy

Li¹,

Chen²,

Liu³

et al. 2020

Journal of Clinical and Translational Hepatology

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Background and Aims: This study was designed to analyze the effects of age and clinicopathological characteristics on prognosis of Chinese patients with hepatocellular carcinoma (HCC). Methods: The clinical data of 2032 HCC patients who were first diagnosed with HCC and underwent curative hepatectomy in our hospital between January 2006 and January 2011 were retrospectively analyzed. Results: Younger HCC patients (age <40 years, n=465) had a significantly higher hepatitis B infection rate, larger tumors, higher alpha-fetoprotein levels, higher preoperative liver function, and more frequent vascular invasions than older patients. Most younger patients were suitable for anatomical hepatectomy, and their tumors were found to be at a highly advanced stage. The recurrence-free survival and overall survival rates of younger HCC patients were significantly worse than those of older patients but this difference disappeared after propensity score matching. Multivariate analysis of pre-matched samples showed that age #40 years was one of the independent risk factors associated with poor overall survival. Conclusions: Younger patients showed different clinicopathological characteristics than older patients, such as higher rates of hepatitis B infection and advanced tumors. The recurrence-free survival and overall survival rates of younger HCC patients after hepatectomy may be similar to those of older patients.

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Section: Discussionsupporting

confidence: 69%

Analysis of Clinicopathological Characteristics and Prognosis of Young Patients with Hepatocellular Carcinoma after Hepatectomy

Li¹,

Chen²,

Liu³

et al. 2020

Journal of Clinical and Translational Hepatology

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“…Kaibori et al 37 reported on 12,587 patients in a Japanese nationwide study that indicated that elderly patients had significantly worse overall survival after hepatectomy than young patients. In contrast, Su et al 38 and Tan et al 39 both suggested older patients with adequate remnant liver reserves and good liver functionality should be considered for curative resection since age was not determined as an independent predictor for overall survival postoperatively. Liver functionality is a crucial factor affecting the prognosis of patients with HCC.…”

Section: Discussionmentioning

confidence: 98%

Prognostic Role of Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Level in Early Stage Hepatocellular Carcinoma

Lin

Hung

et al. 2020

Sci Rep

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The purpose of this study is to evaluate the prognostic value of preoperative Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+-M2BP) in predicting overall survival for patients with hepatitis Band hepatitis C-related early-stage hepatocellular carcinoma (ESHCC) after liver resection. Post-operative survival rates were compared according to WFA+-M2BP level and tumor stage. Six hundred and ten patients were identified and 198 were removed after application of the exclusion criteria; the median follow-up time was 4.33 years, and cancer-related death occurred in 117 (28.4%) patients. Age (p = 0.03), fibrosis grade (p = 0.042), cancer stage (p = 0.01), and WFA+-M2BP level (p = 0.001) were identified as independent risk factors for poor overall survival. The overall survival rates at 3 and 5 years for patients with WFA+-M2BP ≤ 1.12 were 0.92 and 0.90, respectively, and 0.76 and 0.61 for patients with WFA+-M2BP > 1.12 (p < 0.001). During the analysis of survival prediction, serum WfA+-M2BP level exhibited a higher log-likelihood and a lower AIC value compared to TNM stage (log likelihood: −638; AIC: 1279). Pre-operative serum WFA+-M2BP level provided important prognostic information after curative hepatic resection in our study.

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“…Recommended treatments for such patients include transarterial chemoembolization (TACE), radioembolization, or sorafenib, but not hepatic resection. Although the initial version of the BCLC system classified HCC involving a single large tumor (> 5 cm) as intermediate stage [38] , and still guidelines are unclear and somehow contradictory in this sense as recently pointed out [10] , [11] , although recent reviews written by BCLC proponents seems trying to recalibrate their position stating that a single-HCC, regardless of tumor size, should be considered as an early stage disease [52] , [53] , [54] , [55] . Anyhow for patients with single HCC, hepatic resection is first-line therapy.…”

Section: Intermediate Hccmentioning

confidence: 99%

“…However, sorafenib prolongs median overall survival (OS) by only 2–3 months and is associated with higher rates of adverse events and higher cost than the best supportive care [6] , [7] . The more aggressive approach of hepatic resection is a safe and effective option for many patients with intermediate, advanced or complicated HCC, and indeed many liver care centers, make use of this treatment [8] , [9] , [10] , [11] , [12] . This reflects remarkable advances in radiological technology [13] , [14] , surgical techniques, and perioperative care.…”

Section: Introductionmentioning

confidence: 99%

Controversies and evidence of hepatic resection for hepatocellular carcinoma

et al. 2016

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Symptoms of early hepatocellular carcinoma (HCC) often go unnoticed, so more than half of patients with primary HCC are diagnosed after their disease has already reached an intermediate or advanced stage, or after portal hypertension has appeared. While hepatic resection is widely recognized as a first-line therapy to treat very early or early HCC, its use in treating intermediate or advanced HCC or HCC involving portal hypertension remains controversial. Here we review PubMed-indexed literature covering the use of hepatic resection for such patients. The available evidence strongly suggests that, as a result of improvements in surgical techniques and perioperative care, hepatic resection can benefit many patients with intermediate or advanced HCC or with HCC associated with portal hypertension.

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Association between age and overall survival of patients with hepatocellular carcinoma after hepatic resection

Abstract: Age does not influence the prognosis of patients with HCC after hepatic resection. Older patients should be considered for curative resection if remnant liver volume and liver function are adequate. J. Surg. Oncol. 2016;114:966-970. © 2016 Wiley Periodicals, Inc.

Cited by 18 publications

References 44 publications

Analysis of Clinicopathological Characteristics and Prognosis of Young Patients with Hepatocellular Carcinoma after Hepatectomy

Analysis of Clinicopathological Characteristics and Prognosis of Young Patients with Hepatocellular Carcinoma after Hepatectomy

Prognostic Role of Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Level in Early Stage Hepatocellular Carcinoma

Controversies and evidence of hepatic resection for hepatocellular carcinoma

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