Association between advanced maternal age and maternal and neonatal morbidity: A cross-sectional study on a Spanish population

Abstract

Background and objectiveOver recent decades, a progressive increase in the maternal age at childbirth has been observed in developed countries, posing a health risk for both women and infants. The aim of this study was to analyze the association between advanced maternal age (AMA) and maternal and neonatal morbidity.Material and methodsA cross-sectional study of 3,315 births was conducted in the north of Spain in 2014. We compared childbirth between women aged 35 years or older, with a reference group of women aged between 24 and 27 years. AMA was categorized based on ordinal ranking into 35–38 years, 39–42 years, and >42 years to estimate a dose-response pattern (the older the age, the greater the risk). As an association measure, crude and adjusted Odds Ratios (OR) were estimated by non-conditional logistic regression and 95% Confidence Intervals (95%CI) were calculated.ResultsRepeated abortions were more common among women of AMA in comparison to pregnant women aged 24–27 years (reference group): adjusted OR = 2.68; 95%CI (1.52–4.73). A higher prevalence of gestational diabetes was also observed among women of AMA, reaching statistical significance when restricted to first time mothers: adjusted OR = 8.55; 95%CI (1.12–65.43). In addition, the possibility of an instrumental delivery was multiplied by 1.6 and the possibility of a cesarean by 1.5 among women of AMA, with these results reaching statistical significance, and observing a dose-response pattern. Lastly, there were associations between preeclampsia, preterm birth (<37 weeks) and low birthweight, however without reaching statistical significance.ConclusionOur results support the association between AMA and suffering repeated abortions. Likewise, being of AMA was associated with a greater risk of suffering from gestational diabetes, especially among primiparous women, as well as being associated with both instrumental deliveries and cesareans among both primiparous and multiparous women.

Advance Age Pregnancy in a Tertiary Care Centre: A Descriptive Cross-sectional Study

“…In Canada, there has been an increase in the percentage of births from women aged between 35-39 years, ranging from 4.7% in 1982 to 14.1% in 2002. 4 The incidence of pregnancy at advanced maternal age in US was reported as 23% in 2014 and 4.5% from India by Ritu, et al 1 , 3 Prevalence of advance maternal age in our study (5.7%) is much lower than developed country but was comparable with the study done in India. 1 , 3 According to a multi-country data of 2014 The overall prevalence of 29 countries was 12.3% and the prevalence of advanced maternal age was 2.8% in Nepal.…”

Nutritional Health Education in Pregnant Women in a Rural Health Centre: Results in Spanish and Foreign Women

“…The gestational age of the sample in this study is in line with what the Spanish Society of Gynaecology and Obstetrics highlights as most likely to be associated with an adverse outcome during pregnancy [19][20][21][22].…”

circCRAMP1L is a novel biomarker of preeclampsia risk and may play a role in preeclampsia pathogenesis via regulation of the MSP/RON axis in trophoblasts

“…Preeclampsia (PE), a pregnancy-specific syndrome, has a worldwide incidence of approximately 2–8%. With economic and social development, maternal and paternal ages are increasing, leading to larger number of cases of PE [ 1 , 2 ]. PE can threaten the short-term or long-term health of mothers and their offspring [ 3 , 4 ].…”