Association between advanced lung cancer inflammation index and all-cause and cardiovascular mortality among stroke patients: NHANES, 1999–2018

Chen, Xiaokun; Hong, Chunzhan; Guo, Zeming; Huang, Hongyu; Ye, Lichao

doi:10.3389/fpubh.2024.1370322

Cited by 6 publications

References 44 publications

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Advanced lung cancer inflammation index as a predictor of all-cause and cardiovascular mortality among American hypertensive patients

Hu,

Feng,

2024

Preprint

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BACKGROUND The predictive value of advanced lung cancer inflammation index (ALI) in all-cause mortality and cardiovascular mortality among hypertensive patients has not been thoroughly investigated. METHOD AND RESULTS A total of 2805 hypertensive patients from the National Health and Nutrition Examination Surveys from 2005-2006 to 2017-2018 were ultimately included in the analysis. Over the study period, participants were followed up for an average of 57.6 months, during which 311 deaths occurred, with 89 deaths attributed to cardiovascular causes. Survey-weighted restricted cubic spline (RCS) analysis revealed a nonlinear negative correlation between ALI and both all-cause and cardiovascular mortality among hypertensive patients. Survey-weighted Cox proportional hazards models revealed that in the highest ALI quartile experienced a 53.8% reduction in all-cause mortality and an 83.5% reduction in cardiovascular mortality compared with those in the lowest quartile. Survey-weighted Kaplan-Meier survival analysis also revealed that the all-cause mortality and cardiovascular mortality of hypertensive patients in the high ALI group were significantly lower than those in the low ALI group. Time-dependent ROC curves were used to assess the accuracy of survival outcomes and the area under the curve (AUC) values for the ability of ALI to predict all-cause mortality at 1, 3, and 5 years among hypertensive patients were 0.772, 0.672, and 0.634, respectively, whereas the AUC values for predicting cardiovascular mortality were 0.735, 0.760, and 0.723, respectively. CONCLUSIONS ALI can be a valuable and effective tool for identifying high-risk hypertensive patients and guiding targeted interventions.

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Advanced lung cancer inflammation index as a predictor of all-cause and cardiovascular mortality among American hypertensive patients

Hu,

Feng,

2024

Preprint

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Advanced Lung Cancer Inflammation Index ： A Key Predictor of Hepatic Steatosis and Fibrosis Severity

Master,

WANG

2024

Preprint

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Background Inflammation and nutrition are crucial pathogenic mechanisms in Non-alcoholic fatty liver disease (NAFLD). The Advanced Lung Cancer Inflammation Index (ALI) effectively reflects the systemic inflammation level and nutritional metabolic status of patients. However, its relationship with hepatic steatosis and hepatic fibrosis remains unclear. The study aimed to provide novel insights into the prevention of hepatic steatosis and hepatic fibrosis by examining the relationship between the ALI and Controlled Attenuation Parameter (CAP) and Liver Stiffness Measurement (LSM). Methods To identify the connection between ALI and hepatic steatosis and hepatic fibrosis, this study utilized descriptive analysis, multivariate linear regression, smooth curve fitting, and threshold effect analysis to investigate data from the National Health and Nutrition Examination Survey conducted in 2017–2020. Results The ALI levels in the NAFLD and Advanced liver fibrosis (AHF) groups were considerably elevated than the control group, with statistical significance (NAFLD: 70.980 vs. 58.680, P < 0.001; AHF: 72.420 vs. 63.360, P < 0.001). Multiple linear regression analyses indicated significant positive associations between ALI and its quartiles with both CAP and LSM levels. There was a positive smooth curve fitting relationship between ALI and the levels of CAP and LSM, with threshold effect inflection points at 88.287 and 98.420, respectively. Conclusion The findings suggest a positive correlation between elevated ALI levels and the levels of CAP and LSM. Maintaining ALI within an appropriate range may help mitigate the prevalence of hepatic steatosis and hepatic fibrosis.

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Associations of Naples Prognostic Score with Stroke and all-cause mortality in adults : evidence from NHANES (2005-2018)

Xu,

Pei,

Yang

et al. 2024

Preprint

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Objective This study seeks to assess the associations of Naples Prognostic Score with stroke and all-cause mortality in adults. Methods We analyzed data from 44,601 participants in the 2005–2018 National Health and Nutrition Examination Survey (NHANES). The Naples Prognostic Score (NPS) was derived from total cholesterol, serum albumin, neutrophil-to-lymphocyte ratio (NLR), and lymphocyte-to-monocyte ratio (LMR). Participants were classified into three groups based on their NPS. Stroke incidence was determined through self-reported questionnaires, and mortality data were diligently tracked using the National Death Index. We investigated the relationship between NPS and stroke prevalence using multiple logistic regression analysis. To explore the association between NPS and all-cause mortality in stroke survivors, we applied Kaplan-Meier survival analysis and Cox proportional hazards models. Furthermore, we conducted a detailed subgroup analysis to assess interaction effects on all-cause mortality risk within this population. Results The median age of the participants was 50.00 years [interquartile range: 35.00–64.00], with males comprising 49.36% of the study. The overall stroke prevalence was 3.93%. Participants were categorized into three groups based on their NPS: 6,328 (18.1%) in Group 0 (NPS 0), 24,015 (68.8%) in Group 1 (NPS 1 or 2), and 4,580 (13.1%) in Group 2 (NPS 3 or 4). After adjusting for covariates, individuals in Group 2 exhibited a significantly higher stroke prevalence compared to Group 0, with an odds ratio (OR) of 1.83 [95% confidence interval: 1.49–2.26]. Among the 1,372 patients with a history of stroke, with a median follow-up duration of 5.94 years, we utilized Cox proportional hazards models to assess the relationship between NPS and all-cause mortality risk. The analysis revealed that, after adjusting for covariates, stroke patients in Group 2 faced a significantly elevated risk of all-cause mortality (hazard ratio [HR] = 2.08 [95% confidence interval: 1.40–3.09]) compared to those in Group 0. Subsequent subgroup analyses to explore interaction effects on all-cause mortality risk among stroke patients shown no significant interactions (p for interaction > 0.05). Conclusions This study establishes the associations of Naples Prognostic Score with stroke and all-cause mortality in adults.

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Association between advanced lung cancer inflammation index and all-cause and cardiovascular mortality among stroke patients: NHANES, 1999–2018

Cited by 6 publications

References 44 publications

Advanced lung cancer inflammation index as a predictor of all-cause and cardiovascular mortality among American hypertensive patients

Advanced lung cancer inflammation index as a predictor of all-cause and cardiovascular mortality among American hypertensive patients

Advanced Lung Cancer Inflammation Index ： A Key Predictor of Hepatic Steatosis and Fibrosis Severity

Associations of Naples Prognostic Score with Stroke and all-cause mortality in adults : evidence from NHANES (2005-2018)

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