Association between adolescent idiopathic scoliosis prevalence and age at menarche in different geographic latitudes

Grivas, Theodoros B; Vasiliadis, Elias; Mouzakis, Vasilios; Mihas, Constantinos; Koufopoulos, Georgios

doi:10.1186/1748-7161-1-9

Cited by 134 publications

(135 citation statements)

References 100 publications

Supporting

Mentioning

124

Contrasting

Unclassified

Order By: Relevance

“…Age at menarche was also proposed to be related to prevalence of scoliosis. As Grivas et al reported, late age at menarche is parallel with higher prevalence of adolescent idiopathic scoliosis [5,6]. Thus, it is hypothesized that adjustment of menarche age may contribute to predisposition and curve progression potential of idiopathic scoliosis.…”

Section: Introductionmentioning

confidence: 96%

“…Thus, it is hypothesized that adjustment of menarche age may contribute to predisposition and curve progression potential of idiopathic scoliosis. In addition, potential difference of menarche age compared with normal control population may be correlated with hormonal disturbance involving estrogen, melatonin, and leptin [5][6][7][8][9][10], thus contributing to abnormal pubertal growth, which may be responsible for curve onset and progression of AIS. Such hypothesis, first and foremost, warrants menstrual status data supportive of abnormal menarche age with respect to general population.…”

Section: Introductionmentioning

confidence: 99%

“…Such hypothesis, first and foremost, warrants menstrual status data supportive of abnormal menarche age with respect to general population. In the literature, the age at menarche in AIS has been reported as early, normal, and delayed [5,[11][12][13]. Such controversy still exists currently, with no conclusive results.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Timing of menarche in Chinese girls with and without adolescent idiopathic scoliosis: current results and review of the literature

et al. 2010

View full text Add to dashboard Cite

Age at menarche is closely related to scoliosis progression during adolescence. Current data concerning the timing of menarche between scoliotic and non-scoliotic girls in the literature are conflicting, with inconclusive results. The aim of this study was to investigate the distribution difference of age at menarche for adolescent idiopathic scoliosis (AIS) girls and normal control population and to subsequently elucidate the menarche age difference through literature reviewing. Moreover, menarche age of AIS girls with Cobb angle \40°, 40-60°, [60°were compared to estimate its association with curve severity. Menstrual status data were available for 6,376 healthy female adolescents and 2,196 AIS girls. We notice that less than 10% of healthy Chinese girls experienced onset of menses before 11.38 years, and approximately 90% of healthy Chinese girls were menstruating by 13.88 years, with a median age of 12.63 years. As for AIS girls, less than 10% started to menstruate before 11.27 years, and approximately 90% were menstruating by 14.38 years, with a median age of 12.83 years. Average menarche age in AIS (12.83 ± 1.22 years) was significantly later than that of normal control girls (12.63 ± 0.98 years) (p \ 0.001). Age at menarche for AIS affected girls was significantly greater than that of normal control girls at 75%, 90% of whom had attained menarche (p = 0.001, p \ 0.001). Proportion of girls starting to menstruate after 14 years was significantly higher in AIS population compared with normal controls (16.3 vs. 8.1%, p \ 0.001). In addition, AIS girls with Cobb angle [60°experienced onset of menses at an average age of 13.25 years, which was significantly later than AIS girls with Cobb angle \40°(12.81 years, p \ 0.05) and marginally significantly later than AIS girls with Cobb angle between 40 and 60°(12.86 years, p = 0.053). In conclusion, a tendency of delayed onset of menarche was observed in Chinese idiopathic scoliotic girls in this large sample study, especially for girls with Cobb angle [60°, which is supported by multiple previously established positive linkages on AIS etiology studies. Accordingly it is believed that late menarche may contribute importantly to abnormal pubertal growth and subsequently modulate curve behavior in AIS.

show abstract

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Timing of menarche in Chinese girls with and without adolescent idiopathic scoliosis: current results and review of the literature

et al. 2010

View full text Add to dashboard Cite

show abstract

“…A late menarche has been reported to be associated with higher prevalence of AIS [21]. Furthermore, girls with severe scoliosis experienced later menarche than those with mild scoliosis [22][23][24].…”

Section: Discussionmentioning

confidence: 98%

“…BMI was calculated by dividing weight (kg) by height squared (m 2 ) and corrected BMI (cBMI) by dividing weight (kg) by corrected height squared (m 2 ). BMI and cBMI were then expressed in Z-score according to the reference data for the French population (21).…”

Section: Methodsmentioning

confidence: 99%

Fasting total ghrelin levels are increased in patients with adolescent idiopathic scoliosis

Gennero¹,

Conte-Auriol²,

Mus³

et al. 2013

View full text Add to dashboard Cite

Background: A control study was designed to investigate circulating Ghrelin levels in adolescent girls with adolescent idiopathic scoliosis (AIS) and controls. Eating behavioral disorders, endocrine disorders, abnormal growth pattern and osteopenia have been well documented in AIS. Ghrelin is an orexigenic hormone produced by the stomach which reflects body weight changes and stimulates growth hormone secretion. Recently, it has been shown to be associated with bone metabolism and eating behavior. However, the circulating levels of ghrelin have never been evaluated in AIS patients. Methods: Forty nine AIS girls and 15 controls were included. Anthropometric parameters and fasting circulating total ghrelin were measured. Curve severity was evaluated in AIS girls. The relationships between ghrelin and age, body weight, height, body mass index (BMI), BMI Z-score and corrected anthropometric parameters were analyzed in AIS girls and controls. Results: There was no significant difference in body weight, height, BMI or BMI Z-score between AIS and controls. Serum ghrelin level was 1.8 fold higher in AIS girls than in controls. Elevation of ghrelin levels remained significant when corrected BMI or corrected BMI Z-score were considered. Unlike in controls, positive correlations were found between ghrelin and age in AIS girls with a gradual increase of circulating ghrelin with age. Conclusions: We have observed significantly higher circulating ghrelin levels in AIS than in controls with a positive correlation with age. This pilot-study suggests that ghrelin signaling might play a role in the initiation or development of AIS. Further studies are needed to validate theses results.

show abstract

Braces for idiopathic scoliosis in adolescents

Négrini

Minozzi²,

Bettany‐Saltikov

et al. 2015

Cochrane Database of Systematic Reviews

102

View full text Add to dashboard Cite

Due to the important clinical differences among the studies, it was not possible to perform a meta-analysis. Two studies showed that bracing did not change QoL during treatment (low quality), and QoL, back pain, and psychological and cosmetic issues in the long term (16 years) (very low quality). All included papers consistently showed that bracing prevented curve progression (secondary outcome). However, due to the strength of evidence (from low to very low quality), further research is very likely to have an impact on our confidence in the estimate of effect. The high rate of failure of RCTs demonstrates the huge difficulties in performing RCTs in a field where parents reject randomization of their children. This challenge may prevent us from seeing increases in the quality of the evidence over time. Other designs need to be implemented and included in future reviews, including 'expertise-based' trials, prospective controlled cohort studies, prospective studies conducted according to pre-defined criteria such as the Scoliosis Research Society (SRS) and the international Society on Scoliosis Orthopedic and Rehabilitation Treatment (SOSORT) criteria. Future studies should increase their focus on participant outcomes, adverse effects, methods to increase compliance, and usefulness of physiotherapeutic scoliosis specific exercises added to bracing.

show abstract

Association between adolescent idiopathic scoliosis prevalence and age at menarche in different geographic latitudes

Cited by 134 publications

References 100 publications

Timing of menarche in Chinese girls with and without adolescent idiopathic scoliosis: current results and review of the literature

Timing of menarche in Chinese girls with and without adolescent idiopathic scoliosis: current results and review of the literature

Fasting total ghrelin levels are increased in patients with adolescent idiopathic scoliosis

Braces for idiopathic scoliosis in adolescents

Contact Info

Product

Resources

About