Association between admission biomarkers and clinical outcome in older adults diagnosed with an infection in the emergency department

Flamant, Lucas; Orsini, Guillaume Giordano; Ramont, Laurent; Gornet, Marion; Ruffi, Sébastien De; Leroux, Pierre; Kanagaratnam, Lukshe; Gennai, Stéphane

doi:10.1080/17843286.2022.2146929

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…Additionally, they have a weaker immune response to infections, which can affect the kinetics of biomarkers of infection [13]. When interpreting admission biomarkers for older adults with infections, caution must be taken as their prognostic abilities are lower in comparison to younger adults [14,15]. For these reasons, searching for and validation of good biomarkers of disorders common in the senile population is imperative and may facilitate hospitalization, i.e., allow for faster diagnosis and application of effective treatment.…”

Section: Introductionmentioning

confidence: 99%

Preliminary Report on the Influence of Acute Inflammation on Adiponectin Levels in Older Inpatients with Different Nutritional Status

Husejko,

Gackowski,

Wojtasik

et al. 2024

IJMS

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Inflammation can be triggered by a variety of factors, including pathogens, damaged cells, and toxic compounds. It is a biological response of the immune system, which can be successfully assessed in clinical practice using some molecular substances. Because adiponectin, a hormone released by adipose tissue, influences the development of inflammation, its evaluation as a potential measure of inflammation in clinical practice is justified. In the present contribution, statistical comparison of adiponectin concentration and selected molecular substances recognized in clinical practice as measures of inflammation were utilized to demonstrate whether adipose tissue hormones, as exemplified by adiponectin, have the potential to act as a measure of rapidly changing inflammation when monitoring older hospitalized patients in the course of bacterial infection. The study showed no statistically significant differences in adiponectin levels depending on the rapidly changing inflammatory response in its early stage. Interestingly, the concentration of adiponectin is statistically significantly higher in malnourished patients than in people with normal nutritional levels, assessed based on the MNA. According to the results obtained, adiponectin is not an effective measure of acute inflammation in clinical practice. However, it may serve as a biomarker of malnutrition in senile individuals.

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Section: Introductionmentioning

confidence: 99%