Association between adjunct clindamycin and in-hospital mortality in patients with necrotizing soft tissue infection due to group A Streptococcus: a nationwide cohort study

Hamada, Shoichiro; Nakajima, Mikio; Kaszynski, Richard H.; Otaka, Shunichi; Goto, Hideaki; Matsui, Hiroki; Fushimi, Kiyohide; Yamaguchi, Yoshihiro; Yasunaga, Hideo

doi:10.1007/s10096-021-04376-2

Cited by 5 publications

(2 citation statements)

References 33 publications

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“…Combination therapy or alternative treatment options may be employed in cases of reduced susceptibility to Fusidic acid. 11,12 The effectiveness of Mupirocin cream and topical Fusidic acid in treating experimental S. aureus infections was comparable, aligning with clinical observations. Nonetheless, Fusidic acid's effectiveness is reduced against streptococci and is particularly less efficient than Mupirocin cream in addressing S. pyogenes infected wounds.…”

Section: Discussionsupporting

confidence: 70%

Antibiotic resistance and susceptibility pattern of different microorganisms against nadifloxacin

Gala,

Muchhala,

Bhagat

et al. 2023

IJPP

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Skin and soft tissue infections (SSTIs) are common and can have serious implications.Nadifloxacin’s broad-spectrum antibiotic activity may potentially provide therapeutic benefits for skininfections. Also, it offers a viable alternative therapy for topical agent resistance.This study investigates the antimicrobial susceptibility of eight micro-organisms to four important topical antibiotics: Mupirocin, Clindamycin, Fusidic acid, and Nadifloxacin.Antibiotic susceptibility and minimum inhibitory concentration (MIC) were determined using Kirby-Bauer disk diffusion, Epsilometer test (E-Test), and Micro-broth dilution methods. Mueller Hinton and Brucella blood agar served as growth media. HiComb strips from HiMedia were used, and QC strains were tested. Kirby-Bauer assessed Zone of Inhibition; HiComb determined MIC via gradient; Micro-broth dilution gauged growth in antibiotic-diluted broth.The disk diffusion method revealed varying resistance percentages for antibiotics. Clindamycin had the highest resistance (62%) followed by fusidic acid (47%), Nadifloxacin (15%), and mupirocin (5%). Among gram-positive isolates, Nadifloxacin and mupirocin had 100% sensitivity, while Fusidic acid showed moderate resistance (19%) and clindamycin highest resistance (42%). Among gram-negative isolates, clindamycin and fusidic acid had 100% resistance, while Nadifloxacin (42%) and mupirocin (15%) showed comparatively low resistance. Among the 57 species isolates, including 49 isolates of and 8 isolates of the antibiotic susceptibility testing revealed a MIC value <4 μg/ml of Nadifloxacin, with a high level of sensitivity across all isolates. Nadifloxacin’s superior efficacy in the study can be attributed to its mechanism of action, targeting bacterial DNA gyrase and topoisomerase IV, making it suitable for bacterial infections, particularly those involving the skin and soft tissuesOut of four antibiotics tested, Nadifloxacin was found to be effective against both gram-positive and gram-negative strains of bacteria.

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Section: Discussionsupporting

confidence: 70%

Antibiotic resistance and susceptibility pattern of different microorganisms against nadifloxacin

Gala,

Muchhala,

Bhagat

et al. 2023

IJPP

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show abstract

“…1 The β-lactams are the first line of antibiotic therapy and the usefulness of adding clindamycin, which has anti-toxin activity, has recently been reaffirmed, 2 although there is still some controversy about this benefit. 3 Moreover, both excellent cutaneous bioavailability and bacteriological spectrum had dramatically increased its use in some countries. 4 GAS resistance to clindamycin is increasing in these countries with a prevalence reaching around 24% of strains in the United States (USA).…”

Section: E T T E R T O T H E E D I T O R Clindamycin Resistance In Gr...mentioning

confidence: 99%

Clindamycin resistance in Group A streptococcal infections: A single‐centre retrospective cohort study of 186 patients

Salle

Chosidow

Fihman

et al. 2023

Acad Dermatol Venereol

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ICU Management of Invasive β-Hemolytic Streptococcal Infections

Babiker

Kadri

2022

Infectious Disease Clinics of North America

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Association between adjunct clindamycin and in-hospital mortality in patients with necrotizing soft tissue infection due to group A Streptococcus: a nationwide cohort study

Cited by 5 publications

References 33 publications

Antibiotic resistance and susceptibility pattern of different microorganisms against nadifloxacin

Antibiotic resistance and susceptibility pattern of different microorganisms against nadifloxacin

Clindamycin resistance in Group A streptococcal infections: A single‐centre retrospective cohort study of 186 patients

ICU Management of Invasive β-Hemolytic Streptococcal Infections

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