Association between adiponectin gene T45G polymorphism and nonalcoholic fatty liver disease risk: a meta-analysis

Zhang, W; Zhu, Li; Huo, Xiaoqi; Qin, Junqi; Yuan, Guoyue

doi:10.4238/gmr.15017190

Cited by 6 publications

(6 citation statements)

References 20 publications

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“…Like all meta‐analysis, this study certainly has some limitations. First, due to lack of raw data, adjusted analyses were inapplicable, and we have to admit that failure to perform further adjusted analyses for potential confounding factors might impact the reliability of our findings (Zhang, Guo, Qin, & Li, ; Zhang, Zhu, Huo, Qin, & Yuan, ). Second, associations between rs58542926 polymorphisms and chronic liver disease might also be modified by gene‐environmental interactions.…”

Section: Discussionmentioning

confidence: 99%

“…Second, associations between rs58542926 polymorphisms and chronic liver disease might also be modified by geneenvironmental interactions. However, we could not perform relevant analyses accordingly since most of studies did not investigate these associations (Abdel-Hamed, Ghattas, Mesbah, Saleh, & Abo-Elmatty, 2017;Zhang, Guo, et al, 2016;Zhang, Zhu, et al, 2016). Third, gray literatures that were not formally published in academic journals were not considered to be eligible for analyses in this meta-analysis since it is hard to determine their quality.…”

Section: Publication Biasesmentioning

confidence: 99%

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The roles of transmembrane 6 superfamily member 2 rs58542926 polymorphism in chronic liver disease: A meta‐analysis of 24,147 subjects

Chen

Zhou

Luo

et al. 2019

Molec Gen & Gen Med

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Background Some genetic association studies tried to investigate potential associations of transmembrane 6 superfamily member 2 (TM6SF2) polymorphisms with chronic liver disease. However, the results of these studies were not consistent. Thus, we performed the present meta‐analysis to explore associations between TM6SF2 polymorphisms and chronic liver disease in a larger pooled population. Methods Systematic literature research of PubMed, Web of Science, Embase, and CNKI was performed to identify eligible studies for pooled analyses. I2 statistics were employed to assess between‐study heterogeneities. If I2 was greater than 50%, random‐effect models (REMs) would be used to pool the data. Otherwise, fixed‐effect models (FEMs) would be applied for synthetic analyses. Results Totally 28 studies were included for analyses (13,137 cases and 11,010 controls). The pooled analyses showed that rs58542926 polymorphism was significantly associated with chronic liver disease in overall population (dominant model: p < 0.0001, OR = 0.70, 95% CI = 0.64–0.76, I2 = 47%; recessive model: p < 0.0001, OR = 2.94, 95% CI = 2.05–4.20, I2 = 0%; over‐dominant model: p < 0.0001, OR = 1.34, 95% CI = 1.23–1.47, I2 = 0%; allele model: p < 0.0001, OR = 0.68, 95% CI = 0.63–0.73, I2 = 47%), and these significant findings were further confirmed in both Asians and Caucasians. Stratified analyses by type of disease revealed similar positive results in hepatocellular carcinoma (HCC), cirrhosis, alcoholic liver disease (ALD) and NAFLD (Nonalcoholic fatty liver disease), but not in chronic hepatitis B infection (CHB) and chronic hepatitis C infection (CHC). Conclusions These results suggested that TM6SF2 rs58542926 could be used to identify individuals at higher susceptibility to chronic liver disease, especially for HCC, cirrhosis, ALD, and NAFLD.

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Section: Discussionmentioning

confidence: 99%

Section: Publication Biasesmentioning

confidence: 99%

The roles of transmembrane 6 superfamily member 2 rs58542926 polymorphism in chronic liver disease: A meta‐analysis of 24,147 subjects

Chen

Zhou

Luo

et al. 2019

Molec Gen & Gen Med

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“…Both groups of data met our inclusion criteria and were included in our meta-analysis. Among the 28 included studies, 12 studies were carried out in China, [14–25] 3 in Egypt, [7,26,27] 2 in Japan, [28,29] 1 in Taiwan China, [30] 1 studies were performed in the United States, [31] 1 in Korea, [13] 1 in Spain, [32] 1 in Iran [33] and 1 in Switzerland, [34] 1 in Greece, [35] 2 South Korea, [36,37] 1 in Guatemala, [38] 1 in Bangladesh [39] (Table 1). In summary, 3 studies were performed in Africa and twenty in the Asia, and 5 studies were carried out in the western countries.…”

Section: Resultsmentioning

confidence: 99%

Helicobacter pylori infection increases the risk of nonalcoholic fatty liver disease: Possible relationship from an updated meta-analysis

Liu,

Wu,

Ren

et al. 2023

Medicine

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Background: The relationship between Helicobacter pylori (H pylori) infection and nonalcoholic fatty liver disease (NAFLD) has long been debated. Although it has been investigated in many observational studies, the results remain controversial. Therefore, we performed an updated meta-analysis to assess the association between H pylori infection and risk of NAFLD by collecting relevant articles. Methods: Literature collections were conducted by searching PubMed, EMBASE, Web of Science and Cochrane Library databases. Pooled odds ratios with corresponding 95% confidence intervals were calculated to estimate the strength of the link between H pylori infection and NAFLD using Stata 12.0 software. Results: 28 studies with 68,047 cases of NAFLD patients and 134,866 controls were finally included in the meta-analysis. Overall, The results suggested a 27.5% increased risk of developing NAFLD in patients with H pylori infection (odds ratios 1.275 95% confidence intervals 1.179–1.379), although significant heterogeneity was observed. There is no significant publication bias observed based on the funnel plot and Begg test. Subgroup analysis revealed that variables of the study design, study region, publication year, and the method of diagnosing H pylori and NAFLD all contribute to the high heterogeneity, while the positive correlation was seen in all subgroup analysis. Conclusion: This meta-analysis disclosed 1.275-fold increased risk of the occurrence and development of NAFLD in H pylori (+) group compared with the H pylori (−) group, indicating that H pylori is a serious risk factor in patients susceptible to NAFLD.

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“…rs3774261G allele) in a Northeast Han Chinese population ( n = 1514). Furthermore, a recent meta-analysis found no association between the T45G polymorphism of the adiponectin gene and nonalcoholic fatty liver disease (NAFLD) [ 26 ]. It should be noted that NAFLD and its advanced form (i.e.…”

Section: Discussionmentioning

confidence: 99%

Five gene variants in nonagenarians, centenarians and average individuals

Kolovou¹,

Bilianou²,

Giannakopoulou³

et al. 2017

aoms

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IntroductionGenetic factors contribute to the variation of human life span which is believed to be more profound after 85 years of age. The aim of the present study was to evaluate the frequency of 5 gene polymorphisms between nonagenarians, centenarians and average individuals.Material and methodsSingle nucleotide polymorphisms (SNPs) of telomerase reverse transcriptase (TERT; rs2736098), insulin-like growth factor-1 binding protein-3 (IGFBP3; A-202C, rs2857744), fork-head box O3A (FOXO3A; rs13217795 and rs2764264) factor and adiponectin (ADIPOQ; rs2241766) were evaluated in 405 individuals: n = 256 nonagenarians and centenarians (study group) and n = 149 average lifespan individuals (control group aged 18 – < 80 years).ResultsThe frequency of women was significantly higher in the study group than the control group (64.5 vs. 49.7%, p = 0.004). Genotypic and allele frequencies did not differ between groups according to gender. However, in men, the frequency of TT genotype of FOXO3A; rs2764264 was higher in the study group than the control group (45.6 vs. 28.0%, p = 0.05). Overall, the frequency of the C allele of FOXO3A; rs2764264 was significantly lower in the study group than the control group (3.9 vs. 9.5%, respectively, p = 0.023). Furthermore, in the study group, the T allele was significantly more frequent in the nonagenarians (n = 239) than the centenarians (n = 17) in both FOXO3A; rs13217795 and rs2764264 (64.4 vs. 44.1%, p = 0.018 and 69.7 vs. 50.0%, p = 0.017, respectively).ConclusionsAccording to survival status, there is differentiation in the prevalence of both studied FOXO3A gene polymorphisms. The study group had half of the C alleles compared with the control group and centenarians less frequently had the T allele of both FOXO3A gene polymorphisms compared with nonagenarians. No difference was found between groups according to TERT, IGFBP3 and ADIPOQ gene polymorphisms. It seems that some polymorphisms may be significant in prolonging our lifespan. Nevertheless, confirmation in additional study populations is needed.

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Association between adiponectin gene T45G polymorphism and nonalcoholic fatty liver disease risk: a meta-analysis

Cited by 6 publications

References 20 publications

The roles of transmembrane 6 superfamily member 2 rs58542926 polymorphism in chronic liver disease: A meta‐analysis of 24,147 subjects

The roles of transmembrane 6 superfamily member 2 rs58542926 polymorphism in chronic liver disease: A meta‐analysis of 24,147 subjects

Helicobacter pylori infection increases the risk of nonalcoholic fatty liver disease: Possible relationship from an updated meta-analysis

Five gene variants in nonagenarians, centenarians and average individuals

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