Association Between Acute Stroke and Metabolic Syndrome

Abstract

Objective: Metabolic syndrome is the cluster of vascular risk factors including insulin resistance, elevated bloodpressure, hyperlipidemia, and obesity. Metabolic syndrome is strongly associated with cardiovascular andcerebrovascular disease. The aim of this study is to find out association between stroke and metabolic syndrome inour population.Methods: In this observational study, a total number of fifty randomly selected patients were studied from July2009 to December 2009 at Medicine ward of Dhaka Medical College Hospital. Definition of metabolic syndromewas taken from the guidelines by the National Cholesterol Education Program Adult Treatment Panel III.Results: Among the study population 46% had metabolic syndrome. This study estimated that Ischaemic stroke ismore common among metabolic syndrome patients (65.2%), but patient without metabolic syndrome had morehaemorrhagic stroke (55.6%).Only 12% patient was found obese. With or without metabolic syndrome most of thepatient had elevated TG (64%) and raised blood pressure (64%).Conclusion: Without obesity, metabolic syndrome is an important risk factor for cerebrovascular disease. Majorityof the patients with metabolic syndrome present as ischemic stroke.Keywords: Stroke; Metabolic syndrome; hypertension; fasting blood sugar; hyperlipidaemia.DOI: 10.3329/jom.v11i2.5453J MEDICINE 2010; 11 : 124-127

Burden of Stroke in Bangladesh

“…Although 46% of patients observed had metabolic syndrome, overall, a higher contribution was seen in the IS cases (65·2%) than in the HS cases (34·8%). Of the 54% of patients without metabolic syndrome, 55·6% were HS patients (9). Atherogenic dyslipidaemia is characterized by increased triglyceride (TG) levels (TG ≥ 150 mg/dl) and decreased high-density lipoprotein (HDL) levels (HDL ≤40 mg/dl) (8).…”

“…Atherogenic dyslipidaemia is characterized by increased triglyceride (TG) levels (TG ≥ 150 mg/dl) and decreased high-density lipoprotein (HDL) levels (HDL ≤40 mg/dl) (8). The data indicated that the majority (64%) of stroke patients had high TG levels and 68% had low HDL levels (9). However, the actual TG and HDL levels were not reported.…”

“…Centrally distributed obesity can be defined either by the waist to hip ratio (a ratio of more than 0·90 and 0·85 for men and women, respectively) or by having a body mass index greater than 30 kg/m 2 for both men and women (8). Based on these definitions, only 12% of patients were categorized as obese (9).…”

“…Of those with high blood pressure, 69•60% were HS patients and 59•3% were IS patients. Forty-four per cent of the patients were also hyperglycaemic with a fasting blood glucose greater than 100 mg/dl (9). Centrally distributed obesity can be defined either by the waist to hip ratio (a ratio of more than 0•90 and 0•85 for men and women, respectively) or by having a body mass index greater than 30 kg/m 2 for both men and women (8).…”