Abstract:Background and objectives:The established methods to demonstrate the neuroprotective efficacy of drugs still use in vivo animal tests. The objective of the present study, therefore, was to develop in vitro screening systems based on digitized fluorescent imaging of individual neurons from neuronal cell cultures as a practical model for assessment of neuroprotectors during excitotoxicity . Methods: Cortical cells from embryonic mice were cultivated on glass coverslips Cells were loaded with the fluorescence dye… Show more
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