Association between ACE polymorphism, cognitive phenotype and APOE E4 allele in a Tunisian population with Alzheimer disease

Abstract

Angiotensin-converting enzyme (ACE) has shown altered activity in patients with neurological diseases. An insertion/deletion (I/D) polymorphism of the ACE gene encoding angiotensin-converting enzyme has been reported to be associated with the risk for Alzheimer's disease (AD), and is generally considered to be a disorder primarily affecting memory. We conducted a case-control study in a sample composed of 85 sporadic AD patients and 90 age- and sex-matched controls to investigate the possible effect of the polymorphism and cognitive profile. Our data revealed an association between the ACE polymorphism and AD risk. There was a significant difference in the ACE allele or genotype frequencies between cases and controls. The D/D genotype showed an increased risk for AD and in the amnestic group and the effect was independent on ApoE genotypes.

Polymorphisms of apolipoprotein E and aneurysmal subarachnoid haemorrhage: A meta-analysis

“…The APOE gene polymorphism is associated with the risk of developing many central nervous system disorders. APOE polymorphism has been recognized as a genetic risk factor for the development of Alzheimer's disease in different populations ( Achouri-Rassas et al, 2015 , Kumar et al, 2015 , Zheng et al, 2016 ). In Chinese population, APOE polymorphism is associated with the risk of developing deep venous thrombosis ( Zhu et al, 2014 ).…”

Analysis of SLCO1B1 and APOE genetic polymorphisms in a large ethnic Hakka population in southern China

“…By different combinations of these three haplotypes, six genotypes (ɛ2/ɛ2, ɛ3/ɛ3, ɛ2/ɛ3, ɛ3/ɛ4, ɛ2/ɛ4, and ɛ4/ɛ4) are formed . Although the frequency of these alleles/genotypes varies among different populations, APOE ɛ3/ɛ3 is the most common genotype, and ε3 is the most predominant allele in most population . Several studies demonstrated that the APOE polymorphisms have been linked to the cardiovascular disease, lipoprotein glomerulopathy, and Alzheimer's disease II .…”

“…16,17 Although the frequency of these alleles/genotypes varies among different populations, APOE ɛ3/ɛ3 is the most common genotype, and ε3 is the most predominant allele in most population. [18][19][20][21] Several studies demonstrated that the APOE polymorphisms have been linked to the cardiovascular disease, lipoprotein glomerulopathy, and Alzheimer's disease II. 22,23 APOE gene polymorphism is related to the effect of statins on lipid-lowering.…”

Association of Increased Serum ACE Activity with Logical Memory Ability in Type 2 Diabetic Patients with Mild Cognitive Impairment

“…The differences may be attributed to the small sample size and the possibility of different races, which were also reported in another study (Mathew et al, 2001). The formation of MCI may be influenced by several genes, and the ACE gene contributes only a slight effect (Vardy et al, 2012; Achouri-Rassas et al, 2016). ACE I/D polymorphism can be in a linkage disequilibrium with the true variants (McCrimmon et al, 2012).…”

“…ACE I/D polymorphism can be in a linkage disequilibrium with the true variants (McCrimmon et al, 2012). Gene–environment interactions may also lead to discrepancies (Achouri-Rassas et al, 2016). …”