Association Between Accumulation of Advanced Glycation End-Products and Hearing Impairment in Community-Dwelling Older People: A Cross-Sectional Sukagawa Study

Niihata, Kakuya; Takahashi, Sei; Kurita, Noriaki; Yajima, Nobuyuki; Omae, Kazuyuki; Fukuma, Shingo; Okano, Takayuki; Nomoto, Yukio; Omori, Koichi; Fukuhara, Shunichi; Hasegawa, Takeshi; Iida, Hidekazu; Kobayashi, Susumu; Sasaki, Shin; Naganuma, Takako; Nishiwaki, Hiroki; Tominaga, Ryoji

doi:10.1016/j.jamda.2017.09.008

Cited by 5 publications

(7 citation statements)

References 24 publications

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“…On the other hand, positive associations of AGE accumulation with certain age-related conditions have been observed even in the healthy population. For example, in our previous study—conducted in the same setting as the present study—we found that SAF was significantly associated with hearing impairment as measured by the pure-tone average, and that the association of 1 AU of SAF with hearing impairment was equivalent to that of 6 years of actual aging in elderly community-dwellers [ 13 ]. These findings suggest that the effect of AGEs on functional decline could differ between organs, and hearing function might deteriorate linearly with AGE accumulation over time, unlike OAB.…”

Section: Discussionmentioning

confidence: 57%

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Association of advanced glycation end-product accumulation with overactive bladder in community-dwelling elderly: A cross-sectional Sukagawa study

Omae

Kurita

Takahashi

et al. 2021

Asian Journal of Urology

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Objective This study aimed to evaluate the influence of advanced glycation end-product (AGE) accumulation on the prevalence and severity of overactive bladder (OAB) in community-dwelling elderly adults. Methods We conducted a cross-sectional study involving 269 Japanese community dwellers aged ≥75 years in 2015. AGE accumulation was non-invasively measured via skin autofluorescence (SAF) values using AGE Reader. The primary and secondary outcomes were the presence and severity of OAB evaluated using the Overactive Bladder Symptom Score (OABSS). Individuals with an urgency score of ≥2 and sum score of ≥3 were considered to have OAB. The associations of SAF with the prevalence and severity of OAB were assessed using logistic and linear regression models, respectively, adjusted for clinically important confounders. Results The median age of participants was 78 years. Of 269 participants, 110 (40.9%) were men and 75 (27.9%) had OAB. The median SAF was 2.2 arbitrary units (AUs). Increasing median SAF was observed with increasing age. Multivariable analysis revealed that SAF was not associated with either the likelihood of having OAB (odds ratio per AU=0.77, 95% confidence interval: 0.37–1.62) or the natural log-transformed OABSS (β per AU=−0.07, 95% confidence interval: −0.26–0.12). Conclusions In this study, AGE accumulation, as assessed by SAF, was not associated with the prevalence and severity of OAB in Japanese community-dwelling elderly people aged ≥75 years.

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Section: Discussionmentioning

confidence: 57%

“…The Sukagawa Study cohort has been described in detail previously [ 13 ]. Briefly, in this cross-sectional study, we recruited residents aged ≥75 years from the central area of Sukagawa City, which is located in the central part of Fukushima Prefecture, Japan.…”

Section: Methodsmentioning

confidence: 99%

Association of advanced glycation end-product accumulation with overactive bladder in community-dwelling elderly: A cross-sectional Sukagawa study

Omae

Kurita

Takahashi

et al. 2021

Asian Journal of Urology

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“…The cohort study evaluated the factors influencing health‐related quality of life, physical and psychological disability, nursing care requirements, and costs of medical and nursing care among very elderly people. Detailed information regarding the study setting has been described previously . In brief, we recruited residents who were independent in terms of activities of daily living.…”

Section: Methodsmentioning

confidence: 99%

“…Detailed information regarding the study setting has been described previously. 13 In brief, we recruited residents who were independent in terms of activities of daily living. Individuals were invited to participate in the health check-up and survey used in this study by the local government of Sukagawa City.…”

Section: Study Setting and Participantsmentioning

confidence: 99%

Gait speed and overactive bladder in the healthy community‐dwelling super elderly: The Sukagawa Study

Omae

Yamamoto

Kurita

et al. 2019

Neurourology and Urodynamics

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Aim The objective of this study is to assess the association of muscle mass, grip strength, and gait speed with overactive bladder (OAB) in community‐dwelling elderly adults. Methods This cross‐sectional study was based on the data collected from 350 Japanese healthy community‐dwelling elderly individuals aged 75 years or older from the Sukagawa Study. Muscle mass (kg) was measured by bioelectrical impedance, whereas grip strength (kg) and gait speed (m/s) were measured by performance testing. Muscle mass and grip strength were corrected for body mass index (BMI). The primary outcome was the presence of OAB, evaluated using the OAB symptom score. Results Of the 314 participants analyzed, 146 (47%) were men and 88 (28%) presented with OAB. The mean (SD) BMI, muscle mass, grip strength, and gait speed were 23.2 (3.2) kg/m 2, 38.4 (7.5) kg, 26.6 (8.1) kg, and 1.2 (0.2) m/s, respectively. Multivariable logistic regression analysis revealed that slower gait speed was associated with a greater likelihood of OAB (adjusted odds ratio [aOR] per −1 SD, 1.47; 95% confidence interval [CI], 1.11‐1.95). No significant associations between muscle mass or grip strength and OAB were noted (aOR per −1 SD, 0.75, 1.03; 95% CI, 0.41‐1.37, 0.62‐1.72, respectively). Slower gait speed was also associated with higher likelihood of urgency and urgency incontinence (aOR per −1 SD, 1.35, 1.40; 95% CI, 1.04‐1.74, 1.06‐1.84, respectively). Conclusions In the healthy community‐dwelling elderly, gait speed was associated with OAB, including urgency and urgency incontinence. Our findings may provide a new framework for OAB management with respect to functional mobility.

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“…The AGEs have been observed in aging and neurodegenerative diseases and exert toxicity through RAGE ligation cascades [ 13 , 14 ]. The AGEs were associated with hearing loss in elderly patients [ 21 ]. RAGE ligation activates multiple neuroinflammatory and neurodegenerative pathways [ 7 , 9 , 28 ] and RAGE activation induces proinflammatory cytokines such as TNF-, IL6, IL1 and iNOS in microglia cells [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Overexpression of the receptor for advanced glycation end-products in the auditory cortex of rats with noise-induced hearing loss

et al. 2021

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Background The receptor for advanced glycation end-products (RAGE) is involved in neuroinflammation. This study investigated the changes in RAGE expression following noise-induced hearing loss. Methods Three-week-old female Sprague–Dawley rats were exposed to 115 dB SPL white noise for 4 h daily for 3 d (noise group, n = 16). In parallel, age and sex-matched control rats were raised under standard conditions without noise exposure (control group, n = 16). After 2 h (noise immediate, n = 8) and 4 wk (noise 4-week, n = 8) of noise exposure, the auditory cortex was harvested and cytoplasmic and nuclear fractions were isolated. The gene expression levels of tumor necrosis factor alpha (TNF-α), interleukin 6 (IL6), interleukin 1 beta (IL1β), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and RAGE were evaluated using real-time reverse transcription polymerase chain reaction. The protein expression levels of nuclear RAGE and cytosolic RAGE were evaluated using western blotting. Additionally, matrix metalloproteinase 9 (MMP9) was pharmacologically inhibited in the noise immediate group, and then nuclear and cytosolic RAGE expression levels were evaluated. Results The noise immediate and noise 4-week groups exhibited increased auditory thresholds at 4, 8, 16, and 32 kHz frequencies. The genes encoding the pro-inflammatory cytokines TNF-α, IL6, IL1β, and NF- κB were increased 3.74, 1.63, 6.42, and 6.23-fold in the noise immediate group, respectively (P = 0.047, 0.043, 0.044, and 0.041). RAGE mRNA expression was elevated 1.42-fold in the noise 4-week group (P = 0.032). Cytosolic RAGE expression was increased 1.76 and 6.99-fold in the noise immediate and noise 4-week groups, respectively (P = 0.04 and 0.03). Nuclear RAGE expression was comparable between the noise and control groups. matrix metalloproteinase 9 (MMP9) inhibition reduced cytosolic RAGE expression in the noise immediate group (P = 0.004). Conclusions Noise exposure increased the expression of cytosolic RAGE in the auditory cortex and upregulated pro-inflammatory genes, but this response could be alleviated by MMP9 inhibition.

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Association Between Accumulation of Advanced Glycation End-Products and Hearing Impairment in Community-Dwelling Older People: A Cross-Sectional Sukagawa Study

Abstract: Our study indicated that high levels of AGEs were independently associated with hearing impairment. Modifying levels of AGEs may prevent hearing impairment.

Cited by 5 publications

References 24 publications

Association of advanced glycation end-product accumulation with overactive bladder in community-dwelling elderly: A cross-sectional Sukagawa study

Association of advanced glycation end-product accumulation with overactive bladder in community-dwelling elderly: A cross-sectional Sukagawa study

Gait speed and overactive bladder in the healthy community‐dwelling super elderly: The Sukagawa Study

Overexpression of the receptor for advanced glycation end-products in the auditory cortex of rats with noise-induced hearing loss

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