Association between academic pressure, NR3C1 gene methylation, and anxiety symptoms among Chinese adolescents: a nested case-control study

Hua, Yilin; Huang, Chao; Guo, Yangfeng; Du, Xueying; Guo, Liling; Wang, Wanxin; Lu, Ciyong; Guo, Lan

doi:10.1186/s12888-023-04816-7

Cited by 3 publications

(2 citation statements)

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“…In a nested case-control study involving Chinese university students (cases, n = 50; controls, n = 100), NR3C1-16 CpG 10 methylation was found to significantly mediate the correlation between academic stress and anxiety symptoms, suggesting that NR3C1-16 CpG 10 DNA methylation could be a potential mechanism underlying adolescent anxiety (Hua et al, 2023). Similarly, a study involving Japanese medical students found the role of epigenetic regulatory factors in academic stress.…”

Section: Epigenetics Of Depression In Adolescentsmentioning

confidence: 91%

Research trend of epigenetics and depression: adolescents' research needs to strengthen

Yuan,

Meng,

et al. 2024

Front. Neurosci.

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ObjectiveWith its high prevalence, depression's pathogenesis remains unclear. Recent attention has turned to the interplay between depression and epigenetic modifications. However, quantitative bibliometric analyses are lacking. This study aims to visually analyze depression epigenetics trends, utilizing bibliometric tools, while comprehensively reviewing its epigenetic mechanisms.MethodsUtilizing the Web of Science core dataset, we collected depression and epigenetics-related studies. Employing VOSViewer software, we visualized data on authors, countries, journals, and keywords. A ranking table highlighted field leaders.ResultsAnalysis encompassed 3,469 depression epigenetics studies published from January 2002 to June 2023. Key findings include: (1) Gradual publication growth, peaking in 2021; (2) The United States and its research institutions leading contributions; (3) Need for enhanced collaborations, spanning international and interdisciplinary efforts; (4) Keyword clustering revealed five main themes—early-life stress, microRNA, genetics, DNA methylation, and histone acetylation—highlighting research hotspots; (5) Limited focus on adolescent depression epigenetics, warranting increased attention.ConclusionTaken together, this study revealed trends and hotspots in depression epigenetics research, underscoring global collaboration, interdisciplinary fusion, and multi-omics data's importance. It discussed in detail the potential of epigenetic mechanisms in depression diagnosis and treatment, advocating increased focus on adolescent research in this field. Insights aid researchers in shaping their investigative paths toward understanding depression's epigenetic mechanisms and antidepressant interventions.

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Section: Epigenetics Of Depression In Adolescentsmentioning

confidence: 91%

Research trend of epigenetics and depression: adolescents' research needs to strengthen

Yuan,

Meng,

et al. 2024

Front. Neurosci.

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“…Furthermore, NR3C1 is implicated in the positive regulation of pri-miRNA transcription by RNA polymerase II. It actively participates in fundamental cellular processes such as glandular synthesis, glucocorticoid signaling pathways, and the regulation of cellular biosynthesis processes [7] . In the human system, NR3C1 is primarily expressed in vital systems such as the digestive system, central nervous system, urogenital system, and respiratory system.…”

Section: Data Collectionmentioning

confidence: 99%

Expression and prognosis of NR3C1 in uterine corpus endometrial carcinoma based on multiple datasets

Shen,

2024

Preprint

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Uterine corpus endometrial carcinoma (UCEC), a prevalent malignancy in the female reproductive system, has witnessed a 30% increase in recent year. Recognizing the significance of early treatment in reducing patient mortality, the identification of potential biomarkers for UCEC plays a crucial role in early diagnosis. This study was to identify key genes associated with UCEC utilizing the Gene Expression Omnibus (GEO) database, followed by validating their prognostic value across multiple databases. Analysis of four UCEC databases (GSE17025, GSE36389, GSE63678, GSE115810) yielded 72 co-expressed genes. KEGG and GO enrichment analyses revealed their involvement in physiological processes such as transcriptional misregulation in cancer. Constructing a Protein-Protein Interaction (PPI) network for these 72 genes, the top 10 genes with significant interactions were identified. Survival regression analysis highlighted NR3C1 as the gene with a substantial impact on UCEC prognostic outcomes. Differential expression analysis indicated lower expression of NR3C1 in UCEC compared to normal endometrial tissue. Cox regression analysis, performed on clinical datasets of UCEC patients, identified clinical stage III, clinical stage IV, age, and NR3C1 as independent prognostic factors influencing UCEC outcomes. The LinkedOmics online database revealed the top 50 positively and negatively correlated genes with NR3C1 in UCEC. Subsequent investigations into the relationship between NR3C1 and tumor-infiltrating immune cells were conducted using R software. Gene set enrichment analysis (GSEA) provided insights into NR3C1-related genes, showing enrichment in processes such as Ribosome, Oxidative phosphorylation in UCEC. Collectively, these comprehensive analyses suggest that NR3C1 may serve as a potential biomarker indicating the prognosis of UCEC.

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Effects of improved on-farm crop storage on DNA methylation of mothers and their infants: evidence from a randomized controlled trial in Kenya

Eichenauer,

Fischer,

Gardini

et al. 2024

Clin Epigenet

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Background Stress during pregnancy can lead to adverse maternal and infant health outcomes through epigenetic changes in the hypothalamic–pituitary–adrenal axis. Among farmers in low-income countries, one important stressor is food insecurity, which can be reduced using hermetic storage bags. This study aimed to determine, for the first time, whether a hermetic storage bag intervention during pregnancy positively affects maternal and infant DNA methylation of the hypothalamic–pituitary–adrenal axis-related genes FKBP5 and NR3C1. We further analyzed whether anthropometrics, stress, and mental health were associated with DNA methylation. Methods This study was part of a larger matched-pair randomized controlled trial focusing on the impact of improved on-farm storage on food security, poverty, and net income of smallholder farming households. A total of N = 149 mothers were recruited by telephone and invited to attend a study appointment at health facilities in Kakamega County, Western Kenya, with their infants in April or May 2021. During the appointment, anthropometric measurements were taken, questionnaires on stress and mental health were administered, and saliva samples were collected. Logistic and multiple linear regression were used to examine the effect of the intervention and related measures on DNA methylation. Results Mothers in the intervention group showed higher mean NR3C1 methylation levels than those in the control group, corrected for multiple testing. Maternal postpartum body mass index was positively associated with infant NR3C1 CpG3 DNA methylation. The more stressful life events a mother had experienced in the previous 12 months (including during pregnancy), the lower her FKBP5 CpG3 methylation levels. Conclusions Food insecurity and stressful life events during pregnancy seem to exert significant effects on maternal DNA methylation. While these stressors did not appear to impact infant DNA methylation in the present study, maternal postpartum body mass index was significantly related to infant methylation. These findings suggest that while infants may be protected from excessive maternal glucocorticoids by placental barrier activity, maternal metabolic status is still reflected in their epigenetic make-up. Trial registration This study was part of a larger matched-pair randomized controlled trial on the impact of improved on-farm crop storage on welfare, nutrition, and human health. Registration can be found in the American Economic Association (AEA) RCT Registry, RCT ID: AEARCTR-0005845.

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Association between academic pressure, NR3C1 gene methylation, and anxiety symptoms among Chinese adolescents: a nested case-control study

Cited by 3 publications

References 56 publications

Research trend of epigenetics and depression: adolescents' research needs to strengthen

Research trend of epigenetics and depression: adolescents' research needs to strengthen

Expression and prognosis of NR3C1 in uterine corpus endometrial carcinoma based on multiple datasets

Effects of improved on-farm crop storage on DNA methylation of mothers and their infants: evidence from a randomized controlled trial in Kenya

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