Association between Abortion History and Perinatal and Neonatal Outcomes of Singleton Pregnancies after Assisted Reproductive Technology

Sun, Hanxiang; Su, Xiujuan; Liu, Yang; Li, Guohua; Liu, Xiaosong; Du, Qiaoling

doi:10.3390/jcm12010001

Cited by 6 publications

(2 citation statements)

References 34 publications

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“…The impact of previous abortions on subsequent pregnancies can involve various mechanisms, including residual effects on cervical competence leading to premature births; endometrial trauma predisposing to placenta previa, and immunological factors like thrombophilias causing placental insu ciency and fetal growth restriction, potentially resulting in intrauterine fetal demise (17)(18)(19). Similar associations has been observed in other studies done elsewhere (20)(21)(22). Implementing history-based screening protocols to identify at-risk advanced-aged mothers with a history of abortions and providing them with closer antenatal follow-up could facilitate timely interventions and help reduce the risks of adverse fetal outcomes.…”

Section: Characteristics Of Study Participantssupporting

confidence: 61%

Adverse fetal outcomes and associated factors among mothers of advanced age at a tertiary hospital, Southwestern Uganda: a cross-sectional study

Masembe,

Migisha,

Turyasingura

et al. 2024

Preprint

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Background: Pregnancies among mothers of advanced age (≥35 years) are inherently associated with poor fetal outcomes. In this study, we determined the proportion of adverse fetal outcomes and identified associated factors among pregnant mothers of advanced age who delivered at Kabale Regional Referral Hospital (KRRH) in Southwestern Uganda. Methods: We conducted a cross-sectional study at KRRH’s Maternity Ward from March to August 2023. We enrolled post-delivery mothers aged ≥35 years. We collected data on socio-demographic, obstetric, and medical characteristics, as well as fetal outcomes, using interviewer-administered structured questionnaires. We defined an adverse fetal outcome as the occurrence of any of the following complications: early neonatal death, preterm birth, congenital anomalies, macrosomia, low APGAR score, or low birth weight, sustained by the fetus or neonate during pregnancy, delivery, or the immediate post-delivery period before discharge from the hospital. We performed multivariable logistic regression to identify factors associated with adverse fetal outcomes. Results: We enrolled 417 participants, of whom 206 (49.4%) were aged 35-37 years. The majority (n=273; 65.5%) were multiparous (parity ≥5). Adverse fetal outcomes occurred in 8.4% (n=36; 95% CI: 6.1-11.5%) of participants, with early neonatal death being the most common (3.6%), followed by low birth weight (2.4%), congenital anomalies (2.6%), macrosomia (1.4%), low APGAR score (1.4%), and preterm birth (1.2%). Prolonged labor (adjusted odds ratio [aOR]=3.71, 95% CI: 1.40-9.85) and a history of abortion (aOR=2.56, 95% CI: 1.17-5.60) were significantly associated with adverse fetal outcomes. Conclusion: Approximately 1 out of every 10 advanced-aged mothers surveyed experienced a poor fetal outcome, with mothers who had prolonged labor or history of abortions having increased odds of the poor fetal outcomes. Close monitoring during pregnancy and neonatal care preparedness among mothers of advanced age especially those with prolonged labour and history of abortion could mitigate risks of adverse fetal outcomes in this study population.

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Section: Characteristics Of Study Participantssupporting

confidence: 61%

Adverse fetal outcomes and associated factors among mothers of advanced age at a tertiary hospital, Southwestern Uganda: a cross-sectional study

Masembe,

Migisha,

Turyasingura

et al. 2024

Preprint

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“…Women who have had abortions in previous pregnancies [32,33], who are affected by thrombophilic disorders [34], or who have conceived using assisted reproductive technologies [32,35] are more susceptible to developing pregnancy diseases attributable to the placenta. GDM is a major cause of placental dysfunction, but, at the same time, it is caused by an abnormal release of hormones, metabolites, and cytokines from this organ [1,2,30].…”

Section: Discussionmentioning

confidence: 99%

Maternal Preconception Body Mass Index Overtakes Age as a Risk Factor for Gestational Diabetes Mellitus

Mirabelli

Tocci

Donnici

et al. 2023

JCM

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Introduction—The purpose of this study was to determine the relative impact of modifiable and non-modifiable risk factors in the development of gestational diabetes mellitus (GDM), with a particular focus on maternal preconception body mass index (BMI) and age, two important determinants of insulin resistance. Understanding the factors that contribute most to the current escalation of GDM rates in pregnant women could help to inform prevention and intervention strategies, particularly in areas where this female endocrine disorder has an elevated prevalence. Methods—A retrospective, contemporary, large population of singleton pregnant women from southern Italy who underwent 75 g OGTT for GDM screening was enrolled at the Endocrinology Unit, “Pugliese Ciaccio” Hospital, Catanzaro. Relevant clinical data were collected, and the characteristics of women diagnosed with GDM or with normal glucose tolerance were compared. The effect estimates of maternal preconception BMI and age as risk factors for GDM development were calculated through correlation and logistic regression analysis by adjusting for potential confounders. Results—Out of the 3856 women enrolled, 885 (23.0%) were diagnosed with GDM as per IADPSG criteria. Advanced maternal age (≥35 years), gravidity, reproductive history of spontaneous abortion(s), previous GDM, and thyroid and thrombophilic diseases, all emerged as non-modifiable risk factors of GDM, whereas preconception overweight or obesity was the sole potentially modifiable risk factor among those investigated. Maternal preconception BMI, but not age, had a moderate positive association with fasting glucose levels at the time of 75 g OGTT (Pearson coefficient: 0.245, p < 0.001). Abnormalities in fasting glucose drove the majority (60%) of the GDM diagnoses in this study. Maternal preconception obesity almost tripled the risk of developing GDM, but even being overweight resulted in a more pronounced increased risk of developing GDM than advanced maternal age (adjusted OR for preconception overweight: 1.63, 95% CI 1.320–2.019; adjusted OR for advanced maternal age: 1.45, 95% CI 1.184–1.776). Conclusions—Excess body weight prior to conception leads to more detrimental metabolic effects than advanced maternal age in pregnant women with GDM. Thus, in areas in which GDM is particularly common, such as southern Italy, measures aiming to counteracting maternal preconception overweight and obesity may be efficient in reducing GDM prevalence.

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Thick endometrium is associated with hypertensive disorders of pregnancy in programmed frozen-thawed embryo transfers: a retrospective analysis of 2,275 singleton deliveries

Meng,

Chen,

Zhang

et al. 2024

Fertility and Sterility

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Association between Abortion History and Perinatal and Neonatal Outcomes of Singleton Pregnancies after Assisted Reproductive Technology

Cited by 6 publications

References 34 publications

Adverse fetal outcomes and associated factors among mothers of advanced age at a tertiary hospital, Southwestern Uganda: a cross-sectional study

Adverse fetal outcomes and associated factors among mothers of advanced age at a tertiary hospital, Southwestern Uganda: a cross-sectional study

Maternal Preconception Body Mass Index Overtakes Age as a Risk Factor for Gestational Diabetes Mellitus

Thick endometrium is associated with hypertensive disorders of pregnancy in programmed frozen-thawed embryo transfers: a retrospective analysis of 2,275 singleton deliveries

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