Association between ABO Blood Groups and Osteoporosis Severity in Chinese Adults Aged 50 Years and over

Bb, Lu; Kh, Li

doi:10.1177/147323001103900327

Cited by 10 publications

(7 citation statements)

References 15 publications

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“…The fact that blood group A was most common in the PKO group of the current study shows consistency with the data of these other two studies. Previous studies in the literature have shown an association between blood group A and disease [17][18][19]. In studies determining the relationship between ABO blood groups and osteoporosis, with the exception of group O, a relationship has been shown with osteoporosis [ 17,18].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies in the literature have shown an association between blood group A and disease [17][18][19]. In studies determining the relationship between ABO blood groups and osteoporosis, with the exception of group O, a relationship has been shown with osteoporosis [ 17,18]. In a study of hip fractures, Buckwalter et al reported increased fracture incidence in the A blood group [19].…”

Section: Discussionmentioning

confidence: 99%

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The correlation between knee osteoarthritis and the ABO blood group system in a Turkish population

Yaradılmış,

Haberal,

Demirkale

et al. 2021

Ann Clin Anal Med

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Aim: This study aimed to determine the validity of the relationship between primary knee osteoarthritis and the ABO blood group system in the Turkish population and whether ABO group system could be a risk factor for early-onset knee osteoarthritis or revision surgery. Material and Methods: A retrospective examination of the data of 2752 patients who underwent knee arthroplasty surgery in our clinic between 2011 and 2019 was carried out. A total of 2436 primary knee osteoarthritis (PKO) patients underwent total knee arthroplasty (TKA) surgery and 206 patients underwent revision knee arthroplasty (RKA). A control group was formed of 22350 individuals aged >40 years from the same geographical region. The frequency of the ABO subgroups (A, B, O, AB) was compared between the primary knee osteoarthritis group and the control group. In addition, ABO subgroups (A, B, O, AB) were determined in the group of patients aged <65 with knee osteoarthritis (early-onset knee osteoarthritis) or revision group. Results: In the PKO group, the female to male ratio was 8:1, and the mean age was 67.2±8 years. The most significant relationship between blood groups and osteoarthritis was found in Group A (p=0.001). Group AB had a significant but low relationship (p=0.002). However, no statistically significant difference was found between age <65 years and >65 years of age (p=0.642). In comparison with the PKO group and RKA, Group A in the revision group was seen at a statistically significantly higher rate (p=0.043). Discussion: Group A blood group was found to be associated with both primary knee osteoarthritis and revision knee arthroplasty.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The correlation between knee osteoarthritis and the ABO blood group system in a Turkish population

Yaradılmış,

Haberal,

Demirkale

et al. 2021

Ann Clin Anal Med

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“…11 Two research groups have independently identified elderly non-O individuals as having an increased incidence and severity of osteoporosis compared with those of blood group O. 12,13 In their study, Choi and Pai found patients with the blood group AB to have the highest frequency of osteoporosis and the lowest bone mineral density. 13 Lourie et al reported group A individuals to be overrepresented in patients with osteoporosis compared with a cohort of blood donors.…”

Section: Discussionmentioning

confidence: 99%

Association of ABO blood group with fracture pattern and mortality in hip fracture patients

Uzoigwe

Smith

Khan

et al. 2014

annals

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Introduction The mechanism of falling has been proposed as the exclusive explanation for hip fracture pattern. Evidence exists that other genetic factors also influence proximal femoral fracture configuration. The ABO blood group serotype has been associated with other pathologies but any role in hip fracture has yet to be definitively characterised. Methods Our National Hip Fracture Database was interrogated over a four-year period. All patients had their blood group retrieved, and this was compared with hip fracture pattern and mortality rates. Confounding factors were accounted for using logistic regression and the Cox proportional hazards model. Results A total of 2,987 consecutive patients presented to our institution. Those with blood group A were significantly more likely to sustain intracapsular fractures than ‘non-A’ individuals (p=0.009). The blood group distribution of patients with intracapsular fractures was identical to that of the national population of England. However, blood group A was less common in patients with intertrochanteric fractures than in the general population (p=0.0002). Even after correction for age and sex, blood group A was associated with a decrease in the odds of suffering an intertrochanteric fracture to 80% (p=0.002). Blood group A had inferior survivorship correcting for age, sex and hip fracture pattern (hazard ratio: 1.14, p=0.035). This may be due to associated increased prevalence of co-morbid disease in this cohort. Conclusions Blood group is an independent predictor of hip fracture pattern, with group A patients more likely to sustain an intracapsular fracture and non-A individuals more likely to sustain an intertrochanteric fracture. The determinants of fracture pattern are likely to be related to complex interactions at a molecular level based on genetic susceptibility. The mechanism of fall may not be the only aetiological determinant of proximal femoral fracture configuration.

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“…This encourages the hypothesis that some G3S are eQTL that may modulate gene expression in the adrenal gland, with gene function dependent on the level of sex hormones. This was also an intriguing finding given that ABO blood groups have been known to associate with osteoporosis and osteoporosis severity (Choi and Pai 2004;Lu and Li 2011). For WHR, we detected previously known, large-magnitude G3S interactions that were discovered using WHR or WHRadjBMI (Heid et al 2010;Randall et al 2013;Shungin et al 2015;Winkler et al 2015), but additionally discovered novel, small magnitude G3S interactions near such genes as ESR1 and ABCA1.…”

Section: Discussionmentioning

confidence: 63%

Deciphering Sex-Specific Genetic Architectures Using Local Bayesian Regressions

et al. 2020

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Many complex human traits exhibit differences between sexes. While numerous factors likely contribute to this phenomenon, growing evidence from genome-wide studies suggest a partial explanation: that males and females from the same population possess differing genetic architectures. Despite this, mapping gene-by-sex (G×S) interactions remains a challenge likely because the magnitude of such an interaction is typically and exceedingly small; traditional genome-wide association techniques may be underpowered to detect such events, due partly to the burden of multiple test correction. Here, we developed a local Bayesian regression (LBR) method to estimate sex-specific SNP marker effects after fully accounting for local linkage-disequilibrium (LD) patterns. This enabled us to infer sex-specific effects and G×S interactions either at the single SNP level, or by aggregating the effects of multiple SNPs to make inferences at the level of small LD-based regions. Using simulations in which there was imperfect LD between SNPs and causal variants, we showed that aggregating sex-specific marker effects with LBR provides improved power and resolution to detect G×S interactions over traditional single-SNP-based tests. When using LBR to analyze traits from the UK Biobank, we detected a relatively large G×S interaction impacting bone mineral density within ABO, and replicated many previously detected large-magnitude G×S interactions impacting waist-to-hip ratio. We also discovered many new G×S interactions impacting such traits as height and body mass index (BMI) within regions of the genome where both male- and female-specific effects explain a small proportion of phenotypic variance (R2 < 1 × 10−4), but are enriched in known expression quantitative trait loci.

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Association between ABO Blood Groups and Osteoporosis Severity in Chinese Adults Aged 50 Years and over

Cited by 10 publications

References 15 publications

The correlation between knee osteoarthritis and the ABO blood group system in a Turkish population

The correlation between knee osteoarthritis and the ABO blood group system in a Turkish population

Association of ABO blood group with fracture pattern and mortality in hip fracture patients

Deciphering Sex-Specific Genetic Architectures Using Local Bayesian Regressions

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