Association between abdominal obesity indices and risk of cardiovascular events in Chinese populations with type 2 diabetes: a prospective cohort study

Qiao, Tingting; Luo, Tao; Pei, Hualian; Yimingniyazi, Bahegu; Aili, Dilihumaer; Aimudula, Aliya; Zhao, Hui; Zhang, Huanwen; Dai, Jianghong; Wang, Duolao

doi:10.1186/s12933-022-01670-x

Cited by 44 publications

(49 citation statements)

References 55 publications

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“…Studies have demonstrated that abdominal obesity is linked to target organ damage in diabetes. 58,59 Our results confirmed that abdominal obesity is linked to altered brain function among T2D patients. The study provides evidence of interventions targeting abdominal obesity and regulating glucose and lipid metabolism during the mid-life of T2D patients.…”

Section: Discussionsupporting

confidence: 80%

Non‐alcoholic fatty liver disease is associated with brain function disruption in type 2 diabetes patients without cognitive impairment

Li,

Zhang,

et al. 2023

Diabetes Obesity Metabolism

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AimsTo investigate the neural static and dynamic intrinsic activity of intra‐/inter‐network topology among patients with type 2 diabetes (T2D) with non‐alcoholic fatty liver disease (NAFLD) and those without NAFLD (T2NAFLD group and T2noNAFLD group, respectively) and to assess the relationship with metabolism.MethodsFifty‐six patients with T2NAFLD, 78 with T2noNAFLD, and 55 healthy controls (HCs) were recruited to the study. Participants had normal cognition and underwent functional magnetic resonance imaging scans, clinical measurements, and global cognition evaluation. Independent component analysis was used to identify frequency spectrum parameters, static functional network connectivity, and temporal properties of dynamic functional network connectivity (P < 0.05, false discovery rate‐corrected). Statistical analysis involved one‐way analysis of covariance with post hoc, partial correlation and canonical correlation analyses.ResultsOur findings showed that: (i) T2NAFLD patients had more disordered glucose and lipid metabolism, had more severe insulin resistance, and were more obese than T2noNAFLD patients; (ii) T2D patients exhibited disrupted brain function, as evidenced by alterations in intra‐/inter‐network topology, even without clinically measurable cognitive impairment; (iii) T2NAFLD patients had more significant reductions in the frequency spectrum parameters of cognitive executive and visual networks than those with T2noNAFLD; and (iv) altered brain function in T2D patients was correlated with postprandial glucose, high‐density lipoprotein cholesterol, and waist‐hip ratio.ConclusionThis study may provide novel insights into neuroimaging correlates for underlying pathophysiological processes inducing brain damage in T2NAFLD. Thus, controlling blood glucose levels, lipid levels and abdominal obesity may reduce brain damage risk in such patients.

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Section: Discussionsupporting

confidence: 80%

Non‐alcoholic fatty liver disease is associated with brain function disruption in type 2 diabetes patients without cognitive impairment

Li,

Zhang,

et al. 2023

Diabetes Obesity Metabolism

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“…CVAI is an index for estimating visceral obesity based on Asian people, and external verification shows that it is positively correlated with VAT. Current studies show that CVAI performs well as an index of visceral obesity in predicting cardiovascular disease in the general population, and is superior to BMI, WC, and VAI [ 32 , 33 , 34 ]. However, the relationship between CVAI and CAS is unknown in steelworkers.…”

Section: Discussionmentioning

confidence: 99%

Association of Chinese Visceral Adiposity Index and Carotid Atherosclerosis in Steelworkers: A Cross-Sectional Study

Wang

et al. 2023

Nutrients

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The Chinese Visceral Adiposity Index (CVAI) is an indicator of visceral adiposity dysfunction used to evaluate the metabolic health of the Chinese population. Steelworkers are more likely to be obese due to their exposure to special occupational factors, and have a higher prevalence of carotid atherosclerosis (CAS). This study aimed to analyze the special relationship between CVAI and CAS among steelworkers. A total of 4075 subjects from a northern steel company were involved in the cross-sectional study. Four logistic regression models were developed to analyze the correlation between CVAI and CAS. In addition, the restricted cubic spline was applied to fit the dose–response association between CVAI and CAS risk. In the study, the prevalence of CAS was approximately 25.94%. After adjustment for potential confounders, we observed a positive correlation between CVAI and CAS risk. Compared to the first CVAI quartile, the effect value odds ratio (OR) and 95% CI in the second, third, and fourth CVAI quartile were 1.523 (1.159–2.000), 2.708 (2.076–3.533), and 4.101 (3.131–5.372), respectively. Additionally, this positive correlation was stable in all subgroups except for female. Furthermore, we also found a non-linear relationship between CVAI and CAS risk (p nonlinear < 0.05). Notably, CVAI could increase the risk of CAS when higher than 106. In conclusion, our study showed that CVAI might be a reliable indicator to identify high-risk populations of CAS among steelworkers.

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“…It is calculated from body mass index and waist circumference, as well as triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) levels [ 4 ]. It shows an association with cardiovascular events [ 5 , 6 , 7 ]. Previously we reported that VAI tertiles were associated with calcium score, and the highest VAI tertile was an independent predictor for the presence of CACS > 100 in males [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte Ratio Is an Independent Risk Factor for Coronary Artery Disease in Central Obesity

Bagyura

Kiss

Lux

et al. 2023

IJMS

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Several inflammatory biomarkers were found to be associated with an increased risk of cardiovascular disease. Neutrophil-to-lymphocyte ratio (NLR) is a marker of subclinical inflammation that increases with the stress response. Visceral adiposity index (VAI) calculated as a combination of anthropometric and metabolic parameters reflects both the extent and function of visceral adipose tissue. Given the association of subclinical inflammation with both obesity and cardiovascular diseases, it is plausible that the inflammation–CVD association is modulated by the amount and function of adipose tissue. Thus, our aim was to examine the association between NLR and coronary artery calcium score (CACS), an intermediate marker of coronary artery disease in asymptomatic patients across VAI tertiles. Methods: Data from 280 asymptomatic participants of a cardiovascular screening program were analysed. In addition to the collection of lifestyle and medical history, a non-contrast cardiac CT scan and laboratory tests were performed on all participants. Multivariate logistic regression was conducted with CACS > 100 as the outcome and with conventional cardiovascular risk factors and NLR, VAI, and NLR by VAI tertile as predictors. Results: We found an interaction between VAI tertiles and NLR; NLR values were similar in the lower VAI tertiles, while they were higher in the CACS > 100 in the 3rd VAI tertile (CACS ≤ 100: 1.94 ± 0.58 vs. CACS > 100: 2.48 ± 1.1, p = 0.008). According to multivariable logistic regression, the interaction between NLR and VAI tertiles remained: NLR was associated with CACS > 100 in the 3rd VAI tertile (OR = 1.67, 95% CI 1.06–2.62, p = 0.03) but not in the lower tertiles even after adjustment for age, sex, smoking, history of hypertension, hyperlipidaemia, and diabetes mellitus, as well as high-sensitivity C-reactive protein. Our findings draw attention to the independent association between subclinical, chronic, systemic inflammation and subclinical coronary disease in obesity.

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Association between abdominal obesity indices and risk of cardiovascular events in Chinese populations with type 2 diabetes: a prospective cohort study

Cited by 44 publications

References 55 publications

Non‐alcoholic fatty liver disease is associated with brain function disruption in type 2 diabetes patients without cognitive impairment

Non‐alcoholic fatty liver disease is associated with brain function disruption in type 2 diabetes patients without cognitive impairment

Association of Chinese Visceral Adiposity Index and Carotid Atherosclerosis in Steelworkers: A Cross-Sectional Study

Neutrophil-to-Lymphocyte Ratio Is an Independent Risk Factor for Coronary Artery Disease in Central Obesity

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