Association between a promoter polymorphism (rs2192752, –1028A/C) of interleukin 1 receptor, type I (IL1R1) and location of papillary thyroid carcinoma in a Korean population

Abstract

The interleukin 1 receptor, type I (IL1R1) is important in the pathogenesis of cancer. We investigated whether single nucleotide polymorphisms (SNPs) of IL1R1 contribute to the development of papillary thyroid carcinoma (PTC), in addition to the clinicopathological features such as the size, number, location, extrathyroidal invasion and metastasis of PTC. Three promoter SNPs (rs949963 -615G/A, rs2192752 -1028A/C and rs3917225 -1099A/G) in IL1R1 were genotyped using direct sequencing in 118 patients with PTC and 347 controls. The odds ratio (OR), 95% confidence interval (CI) and P value were analysed using SNPStats and SNPAnalyzer Pro. For the exact results, Fisher's exact test and Bonferroni correction (P(c)) were performed. The three promoter SNPs of IL1R1 were not associated with PTC development. For the clinicopathological features of PTC, rs2192752 was associated with location (one lobe versus both lobes): dominant model, OR = 3.11, 95% CI = 1.39-6.96, P(c) = 0.015; log-additive model, OR = 2.79, 95% CI = 1.38-5.66, P(c) = 0.0087. The C allele frequency of rs2192752 was higher in the both lobes group (28.0%) than the one lobe group (12.3%) (OR = 2.77, 95% CI = 1.40-5.48, P(c) = 0.009). However, rs949963 and rs3917225 were not correlated with clinicopathological features including location of PTC. The IL1R1 promoter SNP rs2192752 may contribute to the location of PTC, and the C allele of rs2192752 may be a risk factor for the development of PTC in both lobes.

Genetic polymorphisms in IL1R1 and IL1R2 are associated with susceptibility to thyroid cancer in the Chinese Han population

“…Although the significance of rs3917225 is decreased after adjustment for age and gender, the results of this variant could not be fully ignored as a result of its potential effect on thyroid cancer susceptibility in the Chinese Han population. Furthermore, research on a Korean cohort suggested that there was no existing relationship between rs3917225 and the location of PTC, whereas another promoter SNP, rs2192752, harbored a potential role in PTC location and development . Our results corroborate that the substitution occurring on rs3917225 (A to G) might alter the risk of thyroid cancer to a certain degree.…”

“…In this process, two identified receptors, IL1R1 and IL1R2, act as signal receivers that function distinctly and lead to different reaction results, whereas less is known with respect to their genetic variations in relation to thyroid cancer. A previous study focused on the promoter SNPs of IL1R1 and concluded that SNP rs2192752 might be associated with the risk of PTC . Considering the involvement of IL activities in various diseases, we have carried out a series of investigations of different genes and cancers and, in the present study, we evaluated the correlations between the IL1R1 and IL1R2 polymorphisms and thyroid tumorigenesis.…”

“…Their distinct roles in thyroid cancer development may actually be worthy of more attention. A previous study investigated the association of rs2192752 within IL1R1 and papillary thyroid carcinoma (PTC) risk in a population from Korea, highlighting the significance of rs2192752 in the development of PTC . However, the risk associations of IL1R1 and IL1R2 polymorphisms with thyroid cancer are seldom reported in the Chinese Han population.…”

Relationship between interleukin-1 type 1 and 2 receptor gene polymorphisms and the expression level of membrane-bound receptors

“…Nakki et al 32 showed that the A allele is associated with severe hand osteoarthritis. Park et al 33 polymorphism did not associated with papillary thyroid carcinoma. One of the most investigated polymorphisms in the IL1R1 gene is the SNP rs2234650:C.T (also known as 1970 C/ T PstI).…”

The role of the inflammatory microenvironment in thyroid carcinogenesis

“…Alterations in serum concentrations of IL1b have been suggested to differentiate PTCs from atrophic thyroiditis (Kammoun-Krichen et al 2012). The inheritance of the polymorphism rs2192752 in IL1 receptor (IL1R1) increases the risk of PTC, indicating an association of this IL with DTC (Park et al 2012).…”