Association between a Maternal History of Miscarriages and Birth Defects

Campaña, Hebe; Rittler, Mónica; Gili, Juan Antonio; Poletta, Fernando A.; Pawluk, Mariela Soledad; Giménez, Lucas Gabriel; Cosentino, Viviana; Castilla, Eduardo E.; López-Camelo, Jorge S.

doi:10.1002/bdra.23563

Cited by 14 publications

(8 citation statements)

References 42 publications

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“…Previously, no clear risk factors for PBS have been reported. History of recurrent miscarriages has been reported to increase the risk of omphalocele, and also of other congenital anomalies [14,17,18]. Although our results suggest that recurrent miscarriages would be a risk factor for PBS, further studies are warranted to confirm this finding.…”

Section: Discussionmentioning

confidence: 45%

Prune belly syndrome in Finland – A population-based study on current epidemiology and hospital admissions

Pakkasjärvi

Syvänen

Tauriainen

et al. 2021

Journal of Pediatric Urology

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Section: Discussionmentioning

confidence: 45%

Prune belly syndrome in Finland – A population-based study on current epidemiology and hospital admissions

Pakkasjärvi

Syvänen

Tauriainen

et al. 2021

Journal of Pediatric Urology

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“…A high parity implies that more internal and external environmental factors exist in the mother, which may be related to the high proportion of chromosomal abnormalities in the women. Regarding miscarriage, it has been confirmed that miscarriage history is associated with gastroschisis, omphalocele, talipes, spina bifida, and hypospadias [ 24 ]. Birth cohort studies revealed that autoimmune diseases can influence time-to-pregnancy, pregnancy loss, and live birth rate [ 25 ]; miscarriage history is associated with bacterial vaginosis (eg, septic abortion [ 26 ]), which can induce huge toxicity to the fetus [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Birth Defects in Eastern China and the Associated Risk Factors

Wang

et al. 2021

Med Sci Monit

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Background This study aimed to survey the overall situation of birth defects (BDs) among citizens of Hangzhou, China, and the risk factors of different BD types. Material/Methods We collected the data of 4349 perinatal infants with BDs in Hangzhou. The potentially associated risk factors of BDs were recorded and logistic regression analysis was used to predict the high incidence of BDs. Results Among all perinatal infants with BDs, there were 4105 (94.3%) single births, 225 (5.2%) twin births, and 10 (0.2%) multiple births. In clinical outcomes, there were 2477 (57.0%) live births, 1806 (41.5%) dead fetuses, and 11 (0.3%) stillbirths. Down syndrome ranked first, accounting for 30.7% of the total births, followed by cleft lip and polydactyly. Low family income, nulliparity, high parity, high education level, and taking contraceptives in early pregnancy were found to be risk factors of Down syndrome. Low parity, low education level, and pesticide exposure were found to be risk factors of cleft lip. For polydactyly, young age of the mother and a parity above 0 were identified as risk factors. Conclusions Different risks factors can influence BD development and potentially help to predict specific BD types, such as demographic features and harmful exposure in early pregnancy.

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“…First, the prevalence of infantile male hypospadias may be underestimated since 20% of the sample was lost to follow-up and possibly included women with miscarriages and terminated pregnancies. Fetuses born from these women were considered to have a high prevalence of birth defects [ 44 , 45 ]. However, the association between APP and male hypospadias should not be affected by the underestimation.…”

Section: Discussionmentioning

confidence: 99%

Association of abnormal placental perfusion with the risk of male hypospadias: a hospital-based retrospective cohort study

Zhu

Zhang

Peng

et al. 2020

BMC Pregnancy Childbirth

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Background The effect and extent of abnormal placental perfusion (APP) on the risk of male hypospadias are poorly understood. We compared the prevalence of male hypospadias in the offspring of women with APP and quantify the extent of the APP effect on the anomaly. Methods A hospital-based retrospective analysis of births from 2012 to 2016 was conducted in 2018. Women of singleton pregnancy and male infants born to them were included (N = 21,447). A multivariate analysis was performed to compare the prevalence of male hypospadias in infants exposed to APP with those that were not exposed to APP. Results Compared with the infants of women without APP, infants of women with APP showed an increased risk of male hypospadias (odds ratio, 2.40; 95% confidence interval, 1.09–5.29). The male hypospadias cumulative risk increased with the severity of APP. Infants exposed to severe APP had a significantly higher risk of male hypospadias than those without APP exposure (9.2 versus 1.7 per 1000 infants, P < 0.001). A path analysis indicated that 28.18–46.61% of the risk of hypospadias may be attributed to the effect of APP. Conclusions Male hypospadias risk was associated with APP and increased with APP severity, as measured in the second trimester. APP had an important role in the development of the anomaly.

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Association between a Maternal History of Miscarriages and Birth Defects

Cited by 14 publications

References 42 publications

Prune belly syndrome in Finland – A population-based study on current epidemiology and hospital admissions

Prune belly syndrome in Finland – A population-based study on current epidemiology and hospital admissions

Epidemiology of Birth Defects in Eastern China and the Associated Risk Factors

Association of abnormal placental perfusion with the risk of male hypospadias: a hospital-based retrospective cohort study

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